1. Real-Time Observation of "Soft" Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate.
- Author
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Szczerba D, Tan D, Do JL, Titi HM, Mouhtadi S, Chaumont D, Del Carmen Marco de Lucas M, Geoffroy N, Meyer M, Rousselin Y, Hudspeth JM, Schwanen V, Spoerk-Erdely P, Dippel AC, Ivashko O, Gutowski O, Glaevecke P, Bazhenov V, Arhangelskis M, Halasz I, Friščić T, and Kimber SAJ
- Subjects
- Hydrolysis, Salicylates chemistry, Models, Molecular, Organometallic Compounds chemistry, Bismuth chemistry
- Abstract
Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi
9 O7 } and {Bi38 O44 }, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size" clusters can be both stable enough to crystallize and sufficiently labile for further growth.- Published
- 2021
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