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1. Synthesis of taurine-containing peptides, sulfonopeptides, and N- and O-conjugates.

Author

Vertesaljai P, Biswas S, Lebedyeva I, Broggi E, Asiri AM, and Katritzky AR

Subjects
Peptides chemistry, Taurine chemistry, Nitrogen chemistry, Oxygen chemistry, Peptides chemical synthesis, Peptidomimetics chemistry, Sulfhydryl Compounds chemistry, Taurine chemical synthesis, Triazoles chemistry
Abstract

Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO2-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.

Published
2014
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