This special supplement issue of the Astrophysical Journal comprises six coordinated papers that provide the first detailed analyses of the direct sampling of interstellar neutral atoms by the Interstellar Boundary Explorer (IBEX). Interstellar atoms are the detritus of older stars—their stellar winds, novae, and supernovae—spread across the galaxy, which fill the vast interstellar space between the stars. The very local interstellar medium around the Sun is filled with both ionized and neutral atoms with approximately equal numbers, and occasional ionization, charge exchange, and recombination makes them a single interacting material over large distances. IBEX (McComas et al. 2009a) is a NASA Small Explorer mission with the sole, focused science objective to discover the global interaction between the solar wind and the interstellar medium; this objective has primarily been achieved by taking the first global energetic neutral atom (ENA) images, which provide detailed ENA fluxes and energy spectra over all look directions in space. IBEX was launched 2008 October 19 and subsequently maneuvered into a high-altitude, highly elliptical (~15,000 × 300,000 km), roughly week-long orbit. The payload comprises two very high sensitivity, single-pixel ENA cameras: IBEX-Hi (Funsten et al. 2009a), which measures ENAs from ~300 eV to 6 keV, and IBEX-Lo (Fuselier et al. 2009a), which measures ENAs from ~10 eV to 2 keV. The initial IBEX ENA results were published together in a special issue of Science magazine (McComas et al. 2009b; Funsten et al. 2009b; Fuselier et al. 2009b; Schwadron et al. 2009). Since then there have been numerous additional studies of the IBEX ENA observations of the heliosphere, as well as ENAs from the Moon and Earth's magnetosphere (see recent review by McComas et al. 2011 and references therein). Prior to IBEX, the only interstellar neutral atoms to be directly sampled were He, observed by the Ulysses spacecraft a decade ago (Witte et al. 1996; Witte 2004). The first paper published on IBEX observations of interstellar neutral atoms (Mobius et al. 2009) used observations from the spring of 2009, shortly after IBEX achieved its first long-term orbit; that study showed that IBEX is able to directly observe interstellar H and O in addition to He, but provided only limited analysis of these measurements. IBEX has now completed a second full annual season of neutral observations in 2010, which together with the independent 2009 observations provide data adequate to carry out the first round of detailed, quantitative analyses of the IBEX interstellar neutral observations. In this special supplement issue, the IBEX Science Team presents a coordinated series of six articles that focus on various synergistic aspects of these observations, their analyses, and their implications. A critical foundational paper in this volume, Hlond et al. (2012), analyzes the angular pointing knowledge of IBEX observations and demonstrates that the arrival direction knowledge of neutral atoms can be determined to ~0.1° in both spin angle and elevation. This is no mean feat for a Small Explorer mission designed to measure ENAs in 7° × 7° pixels, and largely at much higher energies than the direct interstellar neutrals. In addition, these authors demonstrate that the in-space (post-launch) bore sight of the IBEX-Lo instrument can achieve this accuracy with either the spacecraft's on board attitude control system or an independent Star Sensor that was designed and built directly into the IBEX-Lo instrument. Lee et al. (2012) derive the analytical solution for the hyperbolic trajectories of individual neutral atoms by using Liouville's theorem, including solar gravity and radiation pressure, photoionization and charge exchange, to produce interstellar neutral atom phase-space distributions. These distributions are then transformed into the IBEX reference frame and integrated over the IBEX-Lo instrumental acceptance to provide an analytic solution for the predicted fluid moments of the interstellar neutral atom distributions. This analytic solution for the interstellar neutral parameters provides the basis for a companion paper by Mobius et al. (2012), who analyze the IBEX He (and Ne+O) measurements using the Lee et al. analytic solutions. This approach allows for physical insights into the dominant physical processes, while in another related paper Bzowski et al. (2012) describe a detailed forward model of the interstellar helium from the edge of the heliosphere all the way through the IBEX instrument geometry. Together, these papers show that the prior values for the interstellar flow speed and direction from Ulysses are inconsistent with our new IBEX observations. Mobius et al. (2012) compare the He and O+Ne flow distributions for both 2009 and 2010 and find interstellar flow parameters of ecliptic longitude at ∞ = 79.0° + 3.0°/–3.5°, ecliptic latitude at ∞ = –4.9° ± 0.2°, ISM speed at ∞ = 23.5 + 3.0/–2.0 km s–1, and neutral He temperature = 5000-8200 K. They also find a combined O+Ne temperature of 5300-9000 K, consistent with an isothermal medium for He, O, and Ne. Bzowski et al. (2012) develop and extensively test a detailed forward model simulation of the interstellar He propagation, losses, and measurement in the IBEX-Lo instrument. These simulations start particles at 150 AU and include more detailed physics than the analytic solutions; they therefore complement the analytic method by allowing detailed mapping of the multi-dimensional space of possible solutions. These authors show that the IBEX results are not in statistical agreement with the Ulysses values and provide new best-fit values of ecliptic longitude 79.2°, ecliptic latitude of –5.1°, speed of ~22.8 km s–1, and He temperature is 6200 K. The values obtained with both complementary methods agree with each other and are in agreement with the flow vector of the local interstellar cloud obtained from studies of interstellar absorption (Redfield & Linsky 2008). Bzowski et al. also show evidence for a previously unknown and unanticipated secondary population of helium. Together, the Mobius et al. (2012) and Bzowski et al. (2012) results provide a new interstellar flow direction and a significantly lower velocity of the incoming gas and therefore significantly lower dynamic pressure on the heliosphere, which translates into a heliospheric interaction that is even less dominated by the external dynamic pressure and clearly lies squarely in the middle ground of astrospheres dominated by the external magnetic and dynamic pressures (McComas et al. 2009b). On another topic, Bochsler et al. (2012) report the first direct measurements of interstellar Ne and estimate the interstellar Ne/O abundance ratio, showing a gas-phase Ne/O ratio for the LISM of 0.27 ± 0.10. This value agrees with results obtained from pickup ion observations (Gloeckler & Geiss 2004; Gloeckler & Fisk 2007) and is significantly larger than the solar abundance ratio, indicating that the LISM is different than the Sun's formation region and/or that a substantial portion of the O in the LISM is tied up (and thus "hidden") in grains and/or ices. Finally, Saul et al. (2012) provide the first detailed analysis of the new interstellar H measurements from IBEX. These authors confirm that the arrival direction of interstellar H is offset from that of He. They further show a variation in the strength of the radiation pressure and thus a change in the apparent arrival direction of H penetrating to 1 AU between the first two years of IBEX observations; these results are consistent with solar cycle variations in the radiation pressure, which works opposite to the Sun's gravitational force to effect the penetration of H into the inner heliosphere. Together, these six studies provide the first detailed analyses of the multi-component local interstellar medium—a medium that both effects us by bounding and interacting with our heliosphere, and a medium that gives us a first direct glimpse of non-solar material from the rest of the galaxy.