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The article presents information on a study related to a male diamond python that was presented with multiple black papillated exophytic skin proliferations and signs of pneumonia. It informs that the histopathology of the skin was performed with the help of biopsy and a benign papilloma-like neoplasia was diagnosed. It further informs that the papillomavirus deoxyrionuclic acid (DNA) could be amplified from a biopsy sample with a broad range polymerase chain reaction but due to the histologically benign nature of the papilloma, the skin proliferations were left untreated.