1. Cutting Edge: ACVRL1 Signaling Augments CD8α+ Dendritic Cell Development.
- Author
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Verma, Rohit, Jaiswal, Hemant, Chauhan, Kuldeep Singh, Kaushik, Monika, and Tailor, Prafullakumar
- Subjects
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DENDRITIC cells , *ACTIVIN receptor-like kinase 1 , *GENE expression , *BONE morphogenetic proteins , *TRANSFORMING growth factors , *INTERFERON regulatory factors , *CD8 antigen - Abstract
Dendritic cells (DCs) are a collection of different subtypes, each of which is characterized by specific surface markers, gene-expression patterns, and distinct functions. Members of the IFN regulatory factor family play critical roles in DC development and functions. Recently, Irf8 was shown to activate TGF-b signaling, which led to exacerbated neuroinflammation in the experimental autoimmune encephalomyelitis mouse model. We analyzed the effect of Irf8 on TGF-β/bone morphogenetic protein pathway-specific genes in DCs and identified Acvrl1, a type I TGF-β superfamily receptor, as a gene strongly induced by Irf8 expression. Among various DC subtypes, Acvrl1 is differentially expressed in CD8β+ DCs. ACVRL1 signaling augmented Irf8-directed classical CD8α+ DC development. Irf8 expression is essential for plasmacytoid DC and CD8α+ DC development, and this study demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid DC development while enhancing that of CD8α+ DCs, thus contributing to DC diversity development. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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