1. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
- Author
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Kevin P. Bateman, Spencer D. Dreher, Yong Liu, Ian W. Davies, Zhi-Cai Shi, Tim Cernak, Christopher J. Welch, Erik L. Regalado, Tony Pereira, Roy Helmy, Jonathan Schneeweis, Louis-Charles Campeau, Simon Berritt, Alexander Buitrago Santanilla, Petr Vachal, Michael Shevlin, and Philippe G. Nantermet
- Subjects
High throughput chemistry ,chemistry.chemical_compound ,Multidisciplinary ,Natural product ,Chemistry ,Drug discovery ,Scale (chemistry) ,Molecule ,Nanotechnology - Abstract
Breaking through the milligram floor When chemists synthesize compounds, the threshold for success is at least a milligram of product. This has been true for decades—even though biochemical assays have long since descended into microgram territory—and results in part from the constraints of characterization methods. Buitrago Santanilla et al. present an automated dosing and characterization protocol for optimizing chemical reaction conditions on the microgram scale. This allowed them to screen numerous base and ligand combinations for catalytic C-N bond-forming reactions between complex pairs of compounds, in short supply, that resisted standard coupling conditions. Science , this issue p. 49
- Published
- 2015
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