1. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
- Author
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Rhonda Bassel-Duby, Eric N. Olson, Fenfen Wu, John R. McAnally, Constantine D Troupes, Stephen C. Cannon, Douglas M. Anderson, Ege T. Kavalali, Steven R. Houser, Catherine A. Makarewich, Benjamin R. Winders, Austin L Reese, Benjamin R. Nelson, and Xiongwen Chen
- Subjects
0301 basic medicine ,SERCA ,General Science & Technology ,Knockout ,Proteolipids ,Muscle Proteins ,Biology ,Sarcoplasmic Reticulum Calcium-Transporting ATPases ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Genetic ,medicine ,Animals ,Humans ,Myocyte ,Myocytes ,Multidisciplinary ,Endoplasmic reticulum ,Calcium-Binding Proteins ,RNA ,Skeletal muscle ,Skeletal ,Myocardial Contraction ,Phospholamban ,Cell biology ,Sarcolipin ,Sarcoplasmic Reticulum ,030104 developmental biology ,medicine.anatomical_structure ,Biochemistry ,030220 oncology & carcinogenesis ,Muscle ,Long Noncoding ,medicine.symptom ,Peptides ,Cardiac ,Transcription ,Muscle Contraction ,Muscle contraction - Abstract
Another micropeptide flexes its muscle Genome annotation is a complex but imperfect art. Attesting to its limitations is the growing evidence that certain transcripts annotated as long noncoding RNAs (lncRNAs) in fact code for small peptides with biologically important functions. One such lncRNA-derived micropeptide in mammals is myoregulin, which reduces muscle performance by inhibiting the activity of a key calcium pump. Nelson et al. describe the opposite activity in a second lncRNA-derived micropeptide in mammalian muscle, called DWORF (see the Perspective by Payre and Desplan). This peptide enhances muscle performance by activating the same calcium pump. DWORF may prove to be useful in improving the cardiac muscle function of mammals with heart disease. Science , this issue p. 271 ; see also p. 226
- Published
- 2016