1. Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors
- Author
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David Corujo, Helmut Fuchs, Omry Koren, Torsten Plösch, Martin Hrabé de Angelis, Dorieke J. Dijkstra, Raffaele Gerlini, Archana Tomar, Rebekka Vogtmann, Susan Marschall, Gemma Comas-Armangue, Marcus Buschbeck, Jonatan Darr, Raffaele Teperino, Jan Rozman, Antonio Aguilar-Pimentel, Maximilian Lassi, Valerie Gailus-Durner, Alexandra Gellhaus, F. Scheid, Center for Liver, Digestive and Metabolic Diseases (CLDM), and Reproductive Origins of Adult Health and Disease (ROAHD)
- Subjects
Model organisms ,Male ,SEX-DIFFERENCES ,STRESS ,Offspring ,ved/biology.organism_classification_rank.species ,Cell ,Medizin ,Physiology ,Disease risks ,Biology ,MOUSE ,03 medical and health sciences ,chemistry.chemical_compound ,CLOCKS ,Mice ,0302 clinical medicine ,Feeding behavior ,Corticosterone ,Germ cells ,medicine ,Animals ,Circadian rhythms ,Circadian rhythm ,GLUCOCORTICOIDS ,Model organism ,Male mouse ,030304 developmental biology ,Metabolic health ,0303 health sciences ,Multidisciplinary ,ved/biology ,Fetal growth restriction ,Circadian disruptions ,Phenotype ,Circadian Rhythm ,ddc ,medicine.anatomical_structure ,chemistry ,In utero ,OBESITY ,FETAL-GROWTH ,HORMONES ,030217 neurology & neurosurgery ,RESTRICTION ,RESPONSES - Abstract
Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. Less is known about the role of paternal circadian rhythm for offspring health. Here, we disrupted circadian rhythm in male mice by night-restricted feeding and showed that paternal circadian disruption at conception is important for offspring feeding behavior, metabolic health, and oscillatory transcription. Mechanistically, our data suggest that the effect of paternal circadian disruption is not transferred to the offspring via the germ cells but initiated by corticosterone-based parental communication at conception and programmed during in utero development through a state of fetal growth restriction. These findings indicate paternal circadian health at conception as a newly identified determinant of offspring phenotypes. CA Extern
- Published
- 2020