1. Activation of proto-oncogenes by disruption of chromosome neighborhoods
- Author
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Alla A. Sigova, Matthew H. Porteus, Anne-Laure Valton, Bryan R. Lajoie, Rasmus O. Bak, Abraham S. Weintraub, Job Dekker, Daniel S. Day, Johanna Goldmann, Tong Ihn Lee, Rudolf Jaenisch, Charles H. Li, Denes Hnisz, Richard A. Young, Jessica Reddy, Diego Borges-Rivera, and Zi Peng Fan
- Subjects
Transcriptional Activation ,0301 basic medicine ,Proto-Oncogenes ,T cell ,Chromosomal translocation ,Biology ,Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ,Genome ,Translocation, Genetic ,Fusion gene ,03 medical and health sciences ,medicine ,Humans ,Sequence Deletion ,Chromosome Aberrations ,Genetics ,Regulation of gene expression ,Multidisciplinary ,Gene Expression Regulation, Leukemic ,HEK 293 cells ,Chromosome Mapping ,Cell biology ,HEK293 Cells ,030104 developmental biology ,medicine.anatomical_structure ,Mutation ,Cancer cell - Abstract
The spread of bad neighborhoods Our genomes have complex three-dimensional (3D) arrangements that partition and regulate gene expression. Cancer cells frequently have their genomes grossly rearranged, disturbing this intricate 3D organization. Hnisz et al. show that the disruption of these 3D neighborhoods can bring oncogenes under the control of regulatory elements normally kept separate from them (see the Perspective by Wala and Beroukim). These novel juxtapositions can result in the inappropriate activation of oncogenes. Science , this issue p. 1454 ; see also p. 1398
- Published
- 2016