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Start Over Author "Zaghi, Mattia" Publisher american association for the advancement of science
1 results on '"Zaghi, Mattia"'

1. A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development.

Author

Benedetti, Valerio, Banfi, Federica, Zaghi, Mattia, Moll-Diaz, Raquel, Massimino, Luca, Argelich, Laura, Bellini, Edoardo, Bido, Simone, Muggeo, Sharon, Ordazzo, Gabriele, Mastrototaro, Giuseppina, Moneta, Matteo, Sessa, Alessandro, and Broccoli, Vania

Subjects
*ZINC-finger proteins, *TRANSCRIPTION factors, *TRANSGENE expression, *EPIGENETICS, *GLIOBLASTOMA multiforme
Abstract

The article offers information about the SOX2-engineered epigenetic silencer (SES) factor represses the glioblastoma genetic program and restrains tumor development. It mentions that SES produces a significant silencing of a large fraction of the SOX2 transcriptional network, achieving high levels of efficacy in repressing aggressive brain tumors.

Published
2022
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