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Start Over Author "Yaoming Li" Publisher american association for the advancement of science

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1. Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells.

Author

Yicun Wang, Jinhui Wu, Hui Chen, Yang Yang, Chengwu Xiao, Xiaoming Yi, Changjie Shi, Ke Zhong, Haowei He, Yaoming Li, Zhenjie Wu, Guangxin Zhou, Qiu Rao, Xiaoxia Wang, Xiaodie Zhou, Lomberk, Gwen, Bing Liu, Jianning Zhao, Jingping Ge, and Wenquan Zhou

Subjects
*CANCER stem cells, *GENOME editing, *METHYLGUANINE, *CRISPRS, *REVERSE transcriptase polymerase chain reaction, *SARCOMA
Abstract

The article discusses osteosarcoma has the common type of bone cancer and the second leading cause of cancer-related deaths in children and adolescents. Topics include cancer stem cells (CSCs) have involved in tumorigenesis, recurrence, and therapy resistance; and to identify critical regulators of sarcoma CSCs, performed a reporter-based genome-wide CRISPR-Cas9 screen.

Published
2021
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