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Your search keyword '"Megy, Karine"' showing total 3 results
Start Over Author "Megy, Karine" Publisher american association for the advancement of science
3 results on '"Megy, Karine"'

1. Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens

Author

Barthotomay, Lyric C., Waterhouse, Robert M., Mayhew, George F., Campbell, Corey L., Michel, Kristin, Zou, Zhen, Ramirez, Jose L., Das, Suchismita, Alvarez, Kanwal, Arensburger, Peter, Bryant, Bart, Chapman, Sinead B., Dong, Yuemei, Erickson, Sara M., Karunaratne, S.H.P. Parakrama, Kokoza, Vladimir, Kodira, Chinnappa D., Pignatelli, Patricia, Shin, Sang Woon, Vanlandingham, Dana L., Atkinson, Peter W., Birren, Bruce, Christophides, George K., Clem, Rollie J., Hemingway, Janet, Higgs, Stephen, Megy, Karine, Ranson, Hilary, Zdobnov, Evgeny M., Raikhel, Alexander S., Christensen, Bruce M., Dimopoulos, George, and Muskavitch, Marc A.T.

Subjects
Pathogenic microorganisms -- Genetic aspects, Mosquitoes -- Genetic aspects, Genomics -- Research, West Nile fever -- Development and progression, West Nile fever -- Genetic aspects, Science and technology
Abstract

The mosquito Culex quinquefsciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance. 10.1126/science.1193162

Published
2010
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2. Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics.

Author

Arensburger, Peter, Megy, Karine, Waterhouse, Robert M., Abrudan, Jenica, Amedeo, Paolo, Antelo, Beatriz, Bartholomay, Lyric, Bidwell, Shelby, Caler, Elisabet, Camara, Francisco, Campbell, Corey L., Campbell, Kathryn S., Casola, Claudio, Castro, Marta T., Chandramouliswaran, Ishwar, Chapman, Sinéad B., Christley, Scott, Costas, Javier, Eisenstadt, Eric, and Feschotte, Cedric

Subjects
*CULEX quinquefasciatus, *MOSQUITO vectors, *MOSQUITO genetics, *NUCLEOTIDE sequence, *GENOMICS, *WEST Nile fever prevention, *VECTOR-pathogen relationships, *XENOBIOTICS, *GENES, *PROTEIN research
Abstract

Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that cause lymphatic filariasis. C. quinquefasciatus is one species within the Culex pipiens species complex and can be found throughout tropical and temperate climates of the world. The ability of C. quinquefasciatus to take blood meals from birds, livestock, and humans contributes to its ability to vector pathogens between species. Here, we describe the genomic sequence of C. quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22% larger than that olAedes aegypti and 52% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory and gustatory receptors, salivary gland genes, and genes associated with xenobiotic detoxification. [ABSTRACT FROM AUTHOR]

Published
2010
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3. Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.

Author

Bartholomay LC, Waterhouse RM, Mayhew GF, Campbell CL, Michel K, Zou Z, Ramirez JL, Das S, Alvarez K, Arensburger P, Bryant B, Chapman SB, Dong Y, Erickson SM, Karunaratne SH, Kokoza V, Kodira CD, Pignatelli P, Shin SW, Vanlandingham DL, Atkinson PW, Birren B, Christophides GK, Clem RJ, Hemingway J, Higgs S, Megy K, Ranson H, Zdobnov EM, Raikhel AS, Christensen BM, Dimopoulos G, and Muskavitch MA

Subjects
Aedes genetics, Aedes immunology, Aedes microbiology, Aedes parasitology, Animals, Anopheles genetics, Anopheles metabolism, Anopheles microbiology, Anopheles parasitology, Arboviruses immunology, Arboviruses pathogenicity, Arboviruses physiology, Bacteria immunology, Bacteria pathogenicity, Biological Evolution, Culex microbiology, Culex parasitology, Ecosystem, Filarioidea immunology, Filarioidea pathogenicity, Filarioidea physiology, Gene Expression Profiling, Gene Expression Regulation, Insect Vectors microbiology, Insect Vectors parasitology, Oligonucleotide Array Sequence Analysis, Phylogeny, RNA Interference, Transcription, Genetic, West Nile virus immunology, West Nile virus pathogenicity, West Nile virus physiology, Culex genetics, Culex immunology, Genes, Insect, Host-Pathogen Interactions, Immunity, Innate genetics, Insect Vectors genetics, Insect Vectors immunology
Abstract

The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.

Published
2010
Full Text
View/download PDF

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