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Start Over Author "Liangxue Lai" Publisher american association for the advancement of science
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1. Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning.

Author

Liangxue Lai, Kolber-Simonds, Donna, Kwang-Wook Park, Hee-Tae Cheong, Greenstein, Julia L., Gi-Sun Im, Samuel, Mellissa, Bonk, Aaron, Rieke, August, Day, Billy N., Murphy, Clifton N., Carter, David B., Hawley, Robert J., and Prather, Randall S.

Subjects
*GALACTOSYLTRANSFERASES, *TRANSPLANTATION of cell nuclei, *CLONING
Abstract

The presence of galactose α-l,3-galactose residues on the surface of pig cells is a major obstacle to successful xenotransplantation. Here, we report the production of four live pigs in which one allele of the α-1,3-galactosyltransferase locus has been knocked out. These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos reconstructed with enucleated pig oocytes. [ABSTRACT FROM AUTHOR]

Published
2002
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