1. Enhanced degradation of EGF receptors by a sorting nexin, SNX1
- Author
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Kurten, Richard C., Cadena, Deborah L., and Gill, Gordon N.
- Subjects
Epidermal growth factor -- Physiological aspects ,Science and technology ,Physiological aspects - Abstract
The vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes., Ligand-activated growth factor and nutrient receptors are internalized by coated pits and transported together to endosomes. The task of segregating receptors destined for lysosomal degradation (such as EGFR) from those [...]
- Published
- 1996