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WHEN PDGF BINDS TO ITS SPECIFIC receptor on the cell surface, the receptor protein becomes phosphorylated on tyrosine residues (autophosphorylated), and the conformation of the cytoplasmic domain of the receptor [...]

The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF., Vascular permeability factor (VPF) was originally purified from guinea pig ascites and tumor cell culture medium as an agent that increases blood vessel permeability [1, 2]. VPF also stimulates migration [...]

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction THE BINDING OF PDGF TO ITS RECEPTOR rapidly activates the receptor's tyrosine kinase and elicits a number of biochemical responses that [...]

A Common PDGF Receptor Is Activated by Homodimeric A and B Forms of PDGF PLATELET-DERIVED GROWTH FACTOR, a major mitogen for cells of mesenchymal origin, is a 32-kD protein heterodimer [...]