1. Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk.
- Author
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Cui, Hengmi, Cruz-Correa, Marcia, Giardiello, Francis M., Hutcheon, David F., Kafonek, David R., Brandenburg, Sheri, Wu, Yiqian, He, Xiaobing, Powe, Neil R., and Feinberg, Andrew P.
- Subjects
- *
GENOMIC imprinting , *COLON cancer - Abstract
Loss of imprinting (LOI), an epigenetic alteration affecting the insulin-like growth factor II gene (IGF2), is found in normal colonic mucosa of about 30% of colorectal cancer (CRC) patients, but it is found in only 10% of healthy individuals. In a pilot study to investigate the utility of LOI as a marker of CRC risk, we evaluated 172 patients at a colonoscopy clinic. The adjusted odds ratio for LOI in lymphocytes was 5.15 for patients with a positive family history [95% confidence interval (95% CI), 1.70 to 16.96; probability P = 0.002], 3.46 for patients with adenomas (95% CI, 1.14 to 11.37; P = 0.026), and 21.7 for patients with CRC (95% CI, 3.48 to 153.6; P = 0.0005). LOI can be assayed with a DNA-based blood test, and it may be a valuable predictive marker of an individual's risk for CRC. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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