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Your search keyword '"Cell Surface Extensions chemistry"' showing total 2 results
Start Over Descriptor "Cell Surface Extensions chemistry" Publisher american association for the advancement of science
2 results on '"Cell Surface Extensions chemistry"'

1. Cell biology. Podosomes and invadopodia help mobile cells step lively.

Author

Marx J

Subjects
Actins analysis, Cell Surface Extensions chemistry, Cell Surface Extensions ultrastructure, Extracellular Matrix metabolism, Gene Expression Regulation, Humans, Macrophages physiology, Neoplasm Metastasis, Neoplasms blood supply, Neoplasms pathology, Neovascularization, Pathologic, Osteoclasts physiology, Wiskott-Aldrich Syndrome Protein genetics, Wiskott-Aldrich Syndrome Protein physiology, Cell Movement, Cell Surface Extensions physiology
Published
2006
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2. Glial membranes at the node of Ranvier prevent neurite outgrowth.

Author

Huang JK, Phillips GR, Roth AD, Pedraza L, Shan W, Belkaid W, Mi S, Fex-Svenningsen A, Florens L, Yates JR 3rd, and Colman DR

Subjects
Animals, Antigens analysis, Axons ultrastructure, Cattle, Cell Surface Extensions chemistry, Cell Surface Extensions ultrastructure, Cells, Cultured, GPI-Linked Proteins, Ganglia, Spinal physiology, Ganglia, Spinal ultrastructure, Humans, Mice, Myelin Proteins, Myelin Sheath chemistry, Myelin-Associated Glycoprotein analysis, Myelin-Oligodendrocyte Glycoprotein, Neurites ultrastructure, Neuroglia chemistry, Oligodendroglia chemistry, Oligodendroglia physiology, Oligodendroglia ultrastructure, Proteoglycans analysis, Proteomics, Ranvier's Nodes chemistry, Ranvier's Nodes ultrastructure, Rats, Spinal Cord cytology, Axons physiology, Cell Surface Extensions physiology, Neurites physiology, Neuroglia physiology, Neuroglia ultrastructure, Ranvier's Nodes physiology
Abstract

Nodes of Ranvier are regularly placed, nonmyelinated axon segments along myelinated nerves. Here we show that nodal membranes isolated from the central nervous system (CNS) of mammals restricted neurite outgrowth of cultured neurons. Proteomic analysis of these membranes revealed several inhibitors of neurite outgrowth, including the oligodendrocyte myelin glycoprotein (OMgp). In rat spinal cord, OMgp was not localized to compact myelin, as previously thought, but to oligodendroglia-like cells, whose processes converge to form a ring that completely encircles the nodes. In OMgp-null mice, CNS nodes were abnormally wide and collateral sprouting was observed. Nodal ensheathment in the CNS may stabilize the node and prevent axonal sprouting.

Published
2005
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