Search

Your search keyword '"Calicheamicin -- Research"' showing total 3 results
Start Over Descriptor "Calicheamicin -- Research" Publisher american association for the advancement of science
3 results on '"Calicheamicin -- Research"'

1. The calicheamicin gene cluster and its iterative type 1 enediyne PKS. (Reports)

Author

Ahlert, Joachim, Shepard, Erica, Lomovskaya, Natalia, Zazopoulos, Emmanuel, Staffa, Alfredo, Bachmann, Brian O., Huang, Kexue, Fonstein, Leonid, Czisny, Anne, Whitwam, Ross E., Farnet, Chris M., and Thorson, Jon S.

Subjects
Calicheamicin -- Research, Science and technology, Research
Abstract

The enediynes exemplify nature's ingenuity. We have cloned and characterized the biosynthetic locus coding for perhaps the most notorious member of the nonchromoprotein enediyne family, calicheamicin. This gene cluster contains an unusual polyketide synthase (PKS) that is demonstrated to be essential for enediyne biosynthesis. Comparison of the calicheamicin locus with the locus encoding the chromoprotein enediyne C-1027 reveals that the enediyne PKS is highly conserved among these distinct enediyne families. Contrary to previous hypotheses, this suggests that the chromoprotein and nonchromoprotein enediynes are generated by similar biosynthetic pathways., Calicheamicin [γ.sub.1.sup.I] (Fig. 1) from Micromonospora echinospora ssp. calichensis is the most prominent member of the nonchromoprotein enediyne family and, as an antitumor agent, is > 5000 times as potent [...]

Published
2002

2. Calicheamicin gamma structure 1: an antitumor antibiotic that cleaves double-stranded DNA site specifically

Author

Zein, Nada, Sinha, Achyut M., McGahren, William J., and Ellestad, George A.

Subjects
DNA -- Research, Calicheamicin -- Research, Antineoplastic agents -- Structure-activity relationships, Antibiotics -- Structure-activity relationships, Science and technology, Research
Abstract

Calicheamicin γ.sup.I/.sub.1: An Antitumor Antibiotic That Cleaves Double-Stranded DNA Site Specifically Calicheamicin γ.sup.I/.sub.1 (Structure 1) (1, 2) has been recently isolated from fermentations of Micromonospora echinospora ssp. calichensis and is [...]

Published
1988

3. Calicheamicin gamma-1-I and DNA: molecular recognition process responsible for site-specificity

Author

Zein, Nada, Poncin, Marc, Nilakantan, Ramaswamy, and Ellestad, George A.

Subjects
DNA -- Analysis -- Research -- Physiological aspects, Antineoplastic antibiotics -- Physiological aspects -- Research, Calicheamicin -- Research, Science and technology, Physiological aspects, Analysis, Research
Abstract

Calicheamicin γ.sub.1/.sup.I and DNA: Molecular Recognition Process Responsible for Site-Specificity AN IMPORTANT AND INTRIGUING ASPECT of the phenomenally potent antitumor agent calicheamicin γ.sub.1/.sup.I (structure 1a) is its interaction in vitro [...]

Published
1989

Catalog

Books, media, physical & digital resources
See catalog results