1. V beta-specific stimulation of human T cells by staphylococcal toxins.
- Author
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Kappler J, Kotzin B, Herron L, Gelfand EW, Bigler RD, Boylston A, Carrel S, Posnett DN, Choi Y, and Marrack P
- Subjects
- Antibodies, Antigens, Differentiation, T-Lymphocyte analysis, Bacterial Toxins immunology, CD3 Complex, CD8 Antigens, HLA Antigens analysis, Humans, Immunoassay, Lymphocyte Activation, Receptors, Antigen, T-Cell analysis, Bacterial Toxins pharmacology, Receptors, Antigen, T-Cell immunology, Staphylococcus, T-Lymphocytes immunology
- Abstract
The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell stimulants. They do not, however, stimulate all T cells. On the contrary, each toxin reacts with human T cells bearing particular V beta sequences as part of their receptors for major histocompatibility complex protein-associated antigen. The specificity of these toxins for V beta s puts them in the recently described class of superantigens and may account for the differential sensitivity of different individuals to the toxic effects of these proteins.
- Published
- 1989
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