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19 results on '"Ponzetta A"'

1. Supplementary Table 2 from Neutrophils Mediate Protection Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22 Production by γδ T Cells

Author

Carnevale, Silvia, primary, Ponzetta, Andrea, primary, Rigatelli, Anna, primary, Carriero, Roberta, primary, Puccio, Simone, primary, Supino, Domenico, primary, Grieco, Giovanna, primary, Molisso, Piera, primary, Di Ceglie, Irene, primary, Scavello, Francesco, primary, Perucchini, Chiara, primary, Pasqualini, Fabio, primary, Recordati, Camilla, primary, Tripodo, Claudio, primary, Belmonte, Beatrice, primary, Mariancini, Andrea, primary, Kunderfranco, Paolo, primary, Sciumè, Giuseppe, primary, Lugli, Enrico, primary, Bonavita, Eduardo, primary, Magrini, Elena, primary, Garlanda, Cecilia, primary, Mantovani, Alberto, primary, and Jaillon, Sebastien, primary

Published
2024
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2. Supplementary Table 1 from Neutrophils Mediate Protection Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22 Production by γδ T Cells

Author

Carnevale, Silvia, primary, Ponzetta, Andrea, primary, Rigatelli, Anna, primary, Carriero, Roberta, primary, Puccio, Simone, primary, Supino, Domenico, primary, Grieco, Giovanna, primary, Molisso, Piera, primary, Di Ceglie, Irene, primary, Scavello, Francesco, primary, Perucchini, Chiara, primary, Pasqualini, Fabio, primary, Recordati, Camilla, primary, Tripodo, Claudio, primary, Belmonte, Beatrice, primary, Mariancini, Andrea, primary, Kunderfranco, Paolo, primary, Sciumè, Giuseppe, primary, Lugli, Enrico, primary, Bonavita, Eduardo, primary, Magrini, Elena, primary, Garlanda, Cecilia, primary, Mantovani, Alberto, primary, and Jaillon, Sebastien, primary

Published
2024
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3. Supplementary Figure S3 from Neutrophils Mediate Protection Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22 Production by γδ T Cells

Author

Carnevale, Silvia, primary, Ponzetta, Andrea, primary, Rigatelli, Anna, primary, Carriero, Roberta, primary, Puccio, Simone, primary, Supino, Domenico, primary, Grieco, Giovanna, primary, Molisso, Piera, primary, Di Ceglie, Irene, primary, Scavello, Francesco, primary, Perucchini, Chiara, primary, Pasqualini, Fabio, primary, Recordati, Camilla, primary, Tripodo, Claudio, primary, Belmonte, Beatrice, primary, Mariancini, Andrea, primary, Kunderfranco, Paolo, primary, Sciumè, Giuseppe, primary, Lugli, Enrico, primary, Bonavita, Eduardo, primary, Magrini, Elena, primary, Garlanda, Cecilia, primary, Mantovani, Alberto, primary, and Jaillon, Sebastien, primary

Published
2024
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4. Data from Neutrophils Mediate Protection Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22 Production by γδ T Cells

Author

Carnevale, Silvia, primary, Ponzetta, Andrea, primary, Rigatelli, Anna, primary, Carriero, Roberta, primary, Puccio, Simone, primary, Supino, Domenico, primary, Grieco, Giovanna, primary, Molisso, Piera, primary, Di Ceglie, Irene, primary, Scavello, Francesco, primary, Perucchini, Chiara, primary, Pasqualini, Fabio, primary, Recordati, Camilla, primary, Tripodo, Claudio, primary, Belmonte, Beatrice, primary, Mariancini, Andrea, primary, Kunderfranco, Paolo, primary, Sciumè, Giuseppe, primary, Lugli, Enrico, primary, Bonavita, Eduardo, primary, Magrini, Elena, primary, Garlanda, Cecilia, primary, Mantovani, Alberto, primary, and Jaillon, Sebastien, primary

Published
2024
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5. Neutrophils mediate protection against colitis and carcinogenesis by controlling bacterial invasion and IL-22 production by γδ T cells

Author

Carnevale, Silvia, primary, Ponzetta, Andrea, additional, Rigatelli, Anna, additional, Carriero, Roberta, additional, Puccio, Simone, additional, Supino, Domenico, additional, Grieco, Giovanna, additional, Molisso, Piera, additional, Di Ceglie, Irene, additional, Scavello, Francesco, additional, Perucchini, Chiara, additional, Pasqualini, Fabio, additional, Recordati, Camilla, additional, Tripodo, Claudio, additional, Belmonte, Beatrice, additional, Mariancini, Andrea, additional, Kunderfranco, Paolo, additional, Sciumè, Giuseppe, additional, Lugli, Enrico, additional, Bonavita, Eduardo, additional, Magrini, Elena, additional, Garlanda, Cecilia, additional, Mantovani, Alberto, additional, and Jaillon, Sebastien, additional

Published
2024
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6. Data from The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance

Author

Del Prete, Annalisa, primary, Sozio, Francesca, primary, Schioppa, Tiziana, primary, Ponzetta, Andrea, primary, Vermi, William, primary, Calza, Stefano, primary, Bugatti, Mattia, primary, Salvi, Valentina, primary, Bernardini, Giovanni, primary, Benvenuti, Federica, primary, Vecchi, Annunciata, primary, Bottazzi, Barbara, primary, Mantovani, Alberto, primary, and Sozzani, Silvano, primary

Published
2023
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7. Supplementary Data from The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance

Author

Del Prete, Annalisa, primary, Sozio, Francesca, primary, Schioppa, Tiziana, primary, Ponzetta, Andrea, primary, Vermi, William, primary, Calza, Stefano, primary, Bugatti, Mattia, primary, Salvi, Valentina, primary, Bernardini, Giovanni, primary, Benvenuti, Federica, primary, Vecchi, Annunciata, primary, Bottazzi, Barbara, primary, Mantovani, Alberto, primary, and Sozzani, Silvano, primary

Published
2023
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8. Supplementary Figure S3 from Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment

Author

Ponzetta, Andrea, primary, Benigni, Giorgia, primary, Antonangeli, Fabrizio, primary, Sciumè, Giuseppe, primary, Sanseviero, Emilio, primary, Zingoni, Alessandra, primary, Ricciardi, Maria Rosaria, primary, Petrucci, Maria Teresa, primary, Santoni, Angela, primary, and Bernardini, Giovanni, primary

Published
2023
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10. Supplementary Table S1 from Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment

Author

Ponzetta, Andrea, primary, Benigni, Giorgia, primary, Antonangeli, Fabrizio, primary, Sciumè, Giuseppe, primary, Sanseviero, Emilio, primary, Zingoni, Alessandra, primary, Ricciardi, Maria Rosaria, primary, Petrucci, Maria Teresa, primary, Santoni, Angela, primary, and Bernardini, Giovanni, primary

Published
2023
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11. Supplementary Material and Methods from Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment

Author

Ponzetta, Andrea, primary, Benigni, Giorgia, primary, Antonangeli, Fabrizio, primary, Sciumè, Giuseppe, primary, Sanseviero, Emilio, primary, Zingoni, Alessandra, primary, Ricciardi, Maria Rosaria, primary, Petrucci, Maria Teresa, primary, Santoni, Angela, primary, and Bernardini, Giovanni, primary

Published
2023
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13. Data from The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance

Author

Silvano Sozzani, Alberto Mantovani, Barbara Bottazzi, Annunciata Vecchi, Federica Benvenuti, Giovanni Bernardini, Valentina Salvi, Mattia Bugatti, Stefano Calza, William Vermi, Andrea Ponzetta, Tiziana Schioppa, Francesca Sozio, and Annalisa Del Prete

Abstract

CCRL2 is a nonsignaling seven-transmembrane domain receptor. CCRL2 binds chemerin, a protein that promotes chemotaxis of leukocytes, including macrophages and natural killer (NK) cells. In addition, CCRL2 controls the inflammatory response in different pathologic settings, such as hypersensitivity, inflammatory arthritis, and experimental autoimmune encephalitis. Here, we investigated the role of CCRL2 in the regulation of lung cancer–related inflammation. The genetic deletion of Ccrl2 promoted tumor progression in urethane-induced and in KrasG12D/+/p53LoxP lung tumor mouse models. Similarly, a Kras-mutant lung tumor displayed enhanced growth in Ccrl2-deficient mice. This phenotype was associated with a reduced inflammatory infiltrate characterized by the impaired recruitment of several leukocyte populations including NK cells. Bone marrow chimeras showed that CCRL2 expression by the nonhematopoietic cell compartment was responsible for the increased tumor formation observed in Kras-mutant Ccrl2-deficient mice. In human and mouse lungs, CCRL2 was expressed by a fraction of CD31+ endothelial cells, where it could control NK infiltration. Elevated CCRL2 expression in biopsies from human lung adenocarcinoma positively correlated with clinical outcome. These results provide evidence for a crucial role of CCRL2 in shaping an anti–lung tumor immune response.

Published
2023

14. Supplementary Figure S1 from Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment

Author

Giovanni Bernardini, Angela Santoni, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Alessandra Zingoni, Emilio Sanseviero, Giuseppe Sciumè, Fabrizio Antonangeli, Giorgia Benigni, and Andrea Ponzetta

Abstract

Supplementary Figure S1. Chemokine expression in serum and spleen of healthy control or MM-bearing mice and 5TGM1 culture supernatants

Published
2023

15. Supplementary Material and Methods from Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment

Author

Giovanni Bernardini, Angela Santoni, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Alessandra Zingoni, Emilio Sanseviero, Giuseppe Sciumè, Fabrizio Antonangeli, Giorgia Benigni, and Andrea Ponzetta

Abstract

Supplementary materials and methods include information related to reagents, cell preparation and NK cell enrichment, FACS analysis, ELISA, functional assays, mixed bone marrow chimera, isolation of BM cell populations and Real-Time PCR

Published
2023

16. Data from Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment

Author

Giovanni Bernardini, Angela Santoni, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Alessandra Zingoni, Emilio Sanseviero, Giuseppe Sciumè, Fabrizio Antonangeli, Giorgia Benigni, and Andrea Ponzetta

Abstract

Natural killer (NK) cells are key innate immune effectors against multiple myeloma, their activity declining in multiple myeloma patients with disease progression. To identify the mechanisms underlying NK cell functional impairment, we characterized the distribution of functionally distinct NK cell subsets in the bone marrow of multiple myeloma-bearing mice. Herein we report that the number of KLRG1− NK cells endowed with potent effector function rapidly and selectively decreases in bone marrow during multiple myeloma growth, this correlating with decreased bone marrow NK cell degranulation in vivo. Altered NK cell subset distribution was dependent on skewed chemokine/chemokine receptor axes in the multiple myeloma microenvironment, with rapid downmodulation of the chemokine receptor CXCR3 on NK cells, increased CXCL9 and CXCL10, and decreased CXCL12 expression in bone marrow. Similar alterations in chemokine receptor/chemokine axes were observed in patients with multiple myeloma. Adoptive transfer experiments demonstrated that KLRG1− NK cell migration to the bone marrow was more efficient in healthy than multiple myeloma–bearing mice. Furthermore, bone marrow localization of transferred CXCR3-deficient NK cells with respect to wild type was enhanced in healthy and multiple myeloma-bearing mice, suggesting that CXCR3 restrains bone marrow NK cell trafficking. Our results indicate that multiple myeloma–promoted CXCR3 ligand upregulation together with CXCL12 downmodulation act as exit signals driving effector NK cells outside the bone marrow, thus weakening the antitumor immune response at the primary site of tumor growth. Cancer Res; 75(22); 4766–77. ©2015 AACR.

Published
2023

18. The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance

Author

Del Prete, Annalisa, primary, Sozio, Francesca, additional, Schioppa, Tiziana, additional, Ponzetta, Andrea, additional, Vermi, William, additional, Calza, Stefano, additional, Bugatti, Mattia, additional, Salvi, Valentina, additional, Bernardini, Giovanni, additional, Benvenuti, Federica, additional, Vecchi, Annunciata, additional, Bottazzi, Barbara, additional, Mantovani, Alberto, additional, and Sozzani, Silvano, additional

Published
2019
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19. Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment

Author

Ponzetta, Andrea, primary, Benigni, Giorgia, additional, Antonangeli, Fabrizio, additional, Sciumè, Giuseppe, additional, Sanseviero, Emilio, additional, Zingoni, Alessandra, additional, Ricciardi, Maria Rosaria, additional, Petrucci, Maria Teresa, additional, Santoni, Angela, additional, and Bernardini, Giovanni, additional

Published
2015
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