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173 results on '"Messina, Jane"'

1. Supplementary Table from Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma

Author

Song, Xiaofei, primary, Chang, Shiun, primary, Seminario-Vidal, Lucia, primary, de Mingo Pulido, Alvaro, primary, Tordesillas, Leticia, primary, Song, Xingzhi, primary, Reed, Rhianna A., primary, Harkins, Andrea, primary, Whiddon, Shannen, primary, Nguyen, Jonathan V., primary, Segura, Carlos Moran, primary, Zhang, Chaomei, primary, Yoder, Sean, primary, Sayegh, Zena, primary, Zhao, Yun, primary, Messina, Jane L., primary, Harro, Carly M., primary, Zhang, Xiaohui, primary, Conejo-Garcia, José R., primary, Berglund, Anders, primary, Sokol, Lubomir, primary, Zhang, Jianhua, primary, Rodriguez, Paulo C., primary, Mulé, James J., primary, Futreal, Andrew P., primary, Tsai, Kenneth Y., primary, and Chen, Pei-Ling, primary

Published
2023
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2. Data from Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma

Author

Song, Xiaofei, primary, Chang, Shiun, primary, Seminario-Vidal, Lucia, primary, de Mingo Pulido, Alvaro, primary, Tordesillas, Leticia, primary, Song, Xingzhi, primary, Reed, Rhianna A., primary, Harkins, Andrea, primary, Whiddon, Shannen, primary, Nguyen, Jonathan V., primary, Segura, Carlos Moran, primary, Zhang, Chaomei, primary, Yoder, Sean, primary, Sayegh, Zena, primary, Zhao, Yun, primary, Messina, Jane L., primary, Harro, Carly M., primary, Zhang, Xiaohui, primary, Conejo-Garcia, José R., primary, Berglund, Anders, primary, Sokol, Lubomir, primary, Zhang, Jianhua, primary, Rodriguez, Paulo C., primary, Mulé, James J., primary, Futreal, Andrew P., primary, Tsai, Kenneth Y., primary, and Chen, Pei-Ling, primary

Published
2023
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3. Data from Ligand-Independent EPHA2 Signaling Drives the Adoption of a Targeted Therapy–Mediated Metastatic Melanoma Phenotype

Author

Paraiso, Kim H.T., primary, Thakur, Meghna Das, primary, Fang, Bin, primary, Koomen, John M., primary, Fedorenko, Inna V., primary, John, Jobin K., primary, Tsao, Hensin, primary, Flaherty, Keith T., primary, Sondak, Vernon K., primary, Messina, Jane L., primary, Pasquale, Elena B., primary, Villagra, Alejandro, primary, Rao, Uma N., primary, Kirkwood, John M., primary, Meier, Friedegund, primary, Sloot, Sarah, primary, Gibney, Geoffrey T., primary, Stuart, Darrin, primary, Tawbi, Hussein, primary, and Smalley, Keiran S.M., primary

Published
2023
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4. Supplementary Data from PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas

Author

Hill, Kristen S., primary, Roberts, Evan R., primary, Wang, Xue, primary, Marin, Ellen, primary, Park, Taeeun D., primary, Son, Sorany, primary, Ren, Yuan, primary, Fang, Bin, primary, Yoder, Sean, primary, Kim, Sungjune, primary, Wan, Lixin, primary, Sarnaik, Amod A., primary, Koomen, John M., primary, Messina, Jane L., primary, Teer, Jamie K., primary, Kim, Youngchul, primary, Wu, Jie, primary, Chalfant, Charles E., primary, and Kim, Minjung, primary

Published
2023
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5. Data from PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas

Author

Hill, Kristen S., primary, Roberts, Evan R., primary, Wang, Xue, primary, Marin, Ellen, primary, Park, Taeeun D., primary, Son, Sorany, primary, Ren, Yuan, primary, Fang, Bin, primary, Yoder, Sean, primary, Kim, Sungjune, primary, Wan, Lixin, primary, Sarnaik, Amod A., primary, Koomen, John M., primary, Messina, Jane L., primary, Teer, Jamie K., primary, Kim, Youngchul, primary, Wu, Jie, primary, Chalfant, Charles E., primary, and Kim, Minjung, primary

Published
2023
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6. Supplementary Figures 1 - 11, Tables 1 - 3 from Ligand-Independent EPHA2 Signaling Drives the Adoption of a Targeted Therapy–Mediated Metastatic Melanoma Phenotype

Author

Paraiso, Kim H.T., primary, Thakur, Meghna Das, primary, Fang, Bin, primary, Koomen, John M., primary, Fedorenko, Inna V., primary, John, Jobin K., primary, Tsao, Hensin, primary, Flaherty, Keith T., primary, Sondak, Vernon K., primary, Messina, Jane L., primary, Pasquale, Elena B., primary, Villagra, Alejandro, primary, Rao, Uma N., primary, Kirkwood, John M., primary, Meier, Friedegund, primary, Sloot, Sarah, primary, Gibney, Geoffrey T., primary, Stuart, Darrin, primary, Tawbi, Hussein, primary, and Smalley, Keiran S.M., primary

Published
2023
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7. Supplementary Data from Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy

Author

Li, Jiannong, primary, Smalley, Inna, primary, Chen, Zhihua, primary, Wu, Jheng-Yu, primary, Phadke, Manali S., primary, Teer, Jamie K., primary, Nguyen, Thanh, primary, Karreth, Florian A., primary, Koomen, John M., primary, Sarnaik, Amod A., primary, Zager, Jonathan S., primary, Khushalani, Nikhil I., primary, Tarhini, Ahmad A., primary, Sondak, Vernon K., primary, Rodriguez, Paulo C., primary, Messina, Jane L., primary, Chen, Y. Ann, primary, and Smalley, Keiran S.M., primary

Published
2023
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8. Supplementary Figure from Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy

Author

Li, Jiannong, primary, Smalley, Inna, primary, Chen, Zhihua, primary, Wu, Jheng-Yu, primary, Phadke, Manali S., primary, Teer, Jamie K., primary, Nguyen, Thanh, primary, Karreth, Florian A., primary, Koomen, John M., primary, Sarnaik, Amod A., primary, Zager, Jonathan S., primary, Khushalani, Nikhil I., primary, Tarhini, Ahmad A., primary, Sondak, Vernon K., primary, Rodriguez, Paulo C., primary, Messina, Jane L., primary, Chen, Y. Ann, primary, and Smalley, Keiran S.M., primary

Published
2023
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9. Supplementary Table 4 from Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases

Author

Smalley, Inna, primary, Chen, Zhihua, primary, Phadke, Manali, primary, Li, Jiannong, primary, Yu, Xiaoqing, primary, Wyatt, Clayton, primary, Evernden, Brittany, primary, Messina, Jane L., primary, Sarnaik, Amod, primary, Sondak, Vernon K., primary, Zhang, Chaomei, primary, Law, Vincent, primary, Tran, Nam, primary, Etame, Arnold, primary, Macaulay, Robert J.B., primary, Eroglu, Zeynep, primary, Forsyth, Peter A., primary, Rodriguez, Paulo C., primary, Chen, Y. Ann, primary, and Smalley, Keiran S.M., primary

Published
2023
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10. Supplementary Table 1 from Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases

Author

Smalley, Inna, primary, Chen, Zhihua, primary, Phadke, Manali, primary, Li, Jiannong, primary, Yu, Xiaoqing, primary, Wyatt, Clayton, primary, Evernden, Brittany, primary, Messina, Jane L., primary, Sarnaik, Amod, primary, Sondak, Vernon K., primary, Zhang, Chaomei, primary, Law, Vincent, primary, Tran, Nam, primary, Etame, Arnold, primary, Macaulay, Robert J.B., primary, Eroglu, Zeynep, primary, Forsyth, Peter A., primary, Rodriguez, Paulo C., primary, Chen, Y. Ann, primary, and Smalley, Keiran S.M., primary

Published
2023
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11. Supplementary Data from The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy

Author

Knepper, Todd C., primary, Montesion, Meagan, primary, Russell, Jeffery S., primary, Sokol, Ethan S., primary, Frampton, Garrett M., primary, Miller, Vincent A., primary, Albacker, Lee A., primary, McLeod, Howard L., primary, Eroglu, Zeynep, primary, Khushalani, Nikhil I., primary, Sondak, Vernon K., primary, Messina, Jane L., primary, Schell, Michael J., primary, DeCaprio, James A., primary, Tsai, Kenneth Y., primary, and Brohl, Andrew S., primary

Published
2023
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12. Supplementary Data from Cutaneous Human Papillomaviruses and the Risk of Keratinocyte Carcinomas

Author

Rollison, Dana E., primary, Amorrortu, Rossybelle P., primary, Zhao, Yayi, primary, Messina, Jane L., primary, Schell, Michael J., primary, Fenske, Neil A., primary, Cherpelis, Basil S., primary, Giuliano, Anna R., primary, Sondak, Vernon K., primary, Pawlita, Michael, primary, McKay-Chopin, Sandrine, primary, Gheit, Tarik, primary, Waterboer, Tim, primary, and Tommasino, Massimo, primary

Published
2023
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13. Supplementary Table 1 from Gene Variants in Angiogenesis and Lymphangiogenesis and Cutaneous Melanoma Progression

Author

Park, Jong Y., primary, Amankwah, Ernest K., primary, Anic, Gabriella M., primary, Lin, Hui-Yi, primary, Walls, Brooke, primary, Park, Hyun, primary, Krebs, Kevin, primary, Madden, Melissa, primary, Maddox, Kristen, primary, Marzban, Suroosh, primary, Fang, Shenying, primary, Chen, Wei, primary, Lee, Jeffrey E., primary, Wei, Qingyi, primary, Amos, Christopher I., primary, Messina, Jane L., primary, Sondak, Vernon K., primary, Sellers, Thomas A., primary, and Egan, Kathleen M., primary

Published
2023
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14. Supplmental Figures 1-3 from Combined BRAF and HSP90 Inhibition in Patients with Unresectable BRAFV600E-Mutant Melanoma

Author

Eroglu, Zeynep, primary, Chen, Y. Ann, primary, Gibney, Geoffrey T., primary, Weber, Jeffrey S., primary, Kudchadkar, Ragini R., primary, Khushalani, Nikhil I., primary, Markowitz, Joseph, primary, Brohl, Andrew S., primary, Tetteh, Leticia F., primary, Ramadan, Howida, primary, Arnone, Gina, primary, Li, Jiannong, primary, Zhao, Xiuhua, primary, Sharma, Ritin, primary, Darville, Lancia N.F., primary, Fang, Bin, primary, Smalley, Inna, primary, Messina, Jane L., primary, Koomen, John M., primary, Sondak, Vernon K., primary, and Smalley, Keiran S.M., primary

Published
2023
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15. Supplementary Data from BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells

Author

Atay, Cigdem, primary, Kwak, Taekyoung, primary, Lavilla-Alonso, Sergio, primary, Donthireddy, Laxminarasimha, primary, Richards, Allison, primary, Moberg, Valerie, primary, Pilon-Thomas, Shari, primary, Schell, Michael, primary, Messina, Jane L., primary, Rebecca, Vito W., primary, Xiao, Min, primary, Tan, Jiufeng, primary, Zhang, Gao, primary, Weber, Jeffrey S., primary, Herlyn, Meenhard, primary, Sarnaik, Amod A., primary, and Gabrilovich, Dmitry I., primary

Published
2023
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16. Supplementary Data from HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy

Author

Emmons, Michael F., primary, Faião-Flores, Fernanda, primary, Sharma, Ritin, primary, Thapa, Ram, primary, Messina, Jane L., primary, Becker, Jurgen C., primary, Schadendorf, Dirk, primary, Seto, Edward, primary, Sondak, Vernon K., primary, Koomen, John M., primary, Chen, Yian A., primary, Lau, Eric K., primary, Wan, Lixin, primary, Licht, Jonathan D., primary, and Smalley, Keiran S.M., primary

Published
2023
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17. Supplementary Table 3 from Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases

Author

Smalley, Inna, primary, Chen, Zhihua, primary, Phadke, Manali, primary, Li, Jiannong, primary, Yu, Xiaoqing, primary, Wyatt, Clayton, primary, Evernden, Brittany, primary, Messina, Jane L., primary, Sarnaik, Amod, primary, Sondak, Vernon K., primary, Zhang, Chaomei, primary, Law, Vincent, primary, Tran, Nam, primary, Etame, Arnold, primary, Macaulay, Robert J.B., primary, Eroglu, Zeynep, primary, Forsyth, Peter A., primary, Rodriguez, Paulo C., primary, Chen, Y. Ann, primary, and Smalley, Keiran S.M., primary

Published
2023
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18. Data from HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy

Author

Emmons, Michael F., primary, Faião-Flores, Fernanda, primary, Sharma, Ritin, primary, Thapa, Ram, primary, Messina, Jane L., primary, Becker, Jurgen C., primary, Schadendorf, Dirk, primary, Seto, Edward, primary, Sondak, Vernon K., primary, Koomen, John M., primary, Chen, Yian A., primary, Lau, Eric K., primary, Wan, Lixin, primary, Licht, Jonathan D., primary, and Smalley, Keiran S.M., primary

Published
2023
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19. Supplementary Table 2 from Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases

Author

Smalley, Inna, primary, Chen, Zhihua, primary, Phadke, Manali, primary, Li, Jiannong, primary, Yu, Xiaoqing, primary, Wyatt, Clayton, primary, Evernden, Brittany, primary, Messina, Jane L., primary, Sarnaik, Amod, primary, Sondak, Vernon K., primary, Zhang, Chaomei, primary, Law, Vincent, primary, Tran, Nam, primary, Etame, Arnold, primary, Macaulay, Robert J.B., primary, Eroglu, Zeynep, primary, Forsyth, Peter A., primary, Rodriguez, Paulo C., primary, Chen, Y. Ann, primary, and Smalley, Keiran S.M., primary

Published
2023
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20. Data from Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy

Author

Li, Jiannong, primary, Smalley, Inna, primary, Chen, Zhihua, primary, Wu, Jheng-Yu, primary, Phadke, Manali S., primary, Teer, Jamie K., primary, Nguyen, Thanh, primary, Karreth, Florian A., primary, Koomen, John M., primary, Sarnaik, Amod A., primary, Zager, Jonathan S., primary, Khushalani, Nikhil I., primary, Tarhini, Ahmad A., primary, Sondak, Vernon K., primary, Rodriguez, Paulo C., primary, Messina, Jane L., primary, Chen, Y. Ann, primary, and Smalley, Keiran S.M., primary

Published
2023
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21. Supplementary Figures 1-12 from Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases

Author

Smalley, Inna, primary, Chen, Zhihua, primary, Phadke, Manali, primary, Li, Jiannong, primary, Yu, Xiaoqing, primary, Wyatt, Clayton, primary, Evernden, Brittany, primary, Messina, Jane L., primary, Sarnaik, Amod, primary, Sondak, Vernon K., primary, Zhang, Chaomei, primary, Law, Vincent, primary, Tran, Nam, primary, Etame, Arnold, primary, Macaulay, Robert J.B., primary, Eroglu, Zeynep, primary, Forsyth, Peter A., primary, Rodriguez, Paulo C., primary, Chen, Y. Ann, primary, and Smalley, Keiran S.M., primary

Published
2023
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22. Supplementary Figure 2 from Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

Author

Dissanayake, Samudra K., primary, Olkhanud, Purevdorj B., primary, O'Connell, Michael P., primary, Carter, Arnell, primary, French, Amanda D., primary, Camilli, Tura C., primary, Emeche, Chineye D., primary, Hewitt, Kyle J., primary, Rosenthal, Devin T., primary, Leotlela, Poloko D., primary, Wade, Michael S., primary, Yang, Sherry W., primary, Brant, Larry, primary, Nickoloff, Brian J., primary, Messina, Jane L., primary, Biragyn, Arya, primary, Hoek, Keith S., primary, Taub, Dennis D., primary, Longo, Dan L., primary, Sondak, Vernon K., primary, Hewitt, Stephen M., primary, and Weeraratna, Ashani T., primary

Published
2023
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24. Supplementary Figure 1 from Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

Author

Dissanayake, Samudra K., primary, Olkhanud, Purevdorj B., primary, O'Connell, Michael P., primary, Carter, Arnell, primary, French, Amanda D., primary, Camilli, Tura C., primary, Emeche, Chineye D., primary, Hewitt, Kyle J., primary, Rosenthal, Devin T., primary, Leotlela, Poloko D., primary, Wade, Michael S., primary, Yang, Sherry W., primary, Brant, Larry, primary, Nickoloff, Brian J., primary, Messina, Jane L., primary, Biragyn, Arya, primary, Hoek, Keith S., primary, Taub, Dennis D., primary, Longo, Dan L., primary, Sondak, Vernon K., primary, Hewitt, Stephen M., primary, and Weeraratna, Ashani T., primary

Published
2023
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26. Data from Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

Author

Dissanayake, Samudra K., primary, Olkhanud, Purevdorj B., primary, O'Connell, Michael P., primary, Carter, Arnell, primary, French, Amanda D., primary, Camilli, Tura C., primary, Emeche, Chineye D., primary, Hewitt, Kyle J., primary, Rosenthal, Devin T., primary, Leotlela, Poloko D., primary, Wade, Michael S., primary, Yang, Sherry W., primary, Brant, Larry, primary, Nickoloff, Brian J., primary, Messina, Jane L., primary, Biragyn, Arya, primary, Hoek, Keith S., primary, Taub, Dennis D., primary, Longo, Dan L., primary, Sondak, Vernon K., primary, Hewitt, Stephen M., primary, and Weeraratna, Ashani T., primary

Published
2023
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29. Supplementary Tables 1-2, Figures 1-12 from PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression

Author

Paraiso, Kim H.T., primary, Xiang, Yun, primary, Rebecca, Vito W., primary, Abel, Ethan V., primary, Chen, Y. Ann, primary, Munko, A. Cecilia, primary, Wood, Elizabeth, primary, Fedorenko, Inna V., primary, Sondak, Vernon K., primary, Anderson, Alexander R.A., primary, Ribas, Antoni, primary, Palma, Maurizia Dalla, primary, Nathanson, Katherine L., primary, Koomen, John M., primary, Messina, Jane L., primary, and Smalley, Keiran S.M., primary

Published
2023
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30. Supplementary Figure 3 from Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

Author

Dissanayake, Samudra K., primary, Olkhanud, Purevdorj B., primary, O'Connell, Michael P., primary, Carter, Arnell, primary, French, Amanda D., primary, Camilli, Tura C., primary, Emeche, Chineye D., primary, Hewitt, Kyle J., primary, Rosenthal, Devin T., primary, Leotlela, Poloko D., primary, Wade, Michael S., primary, Yang, Sherry W., primary, Brant, Larry, primary, Nickoloff, Brian J., primary, Messina, Jane L., primary, Biragyn, Arya, primary, Hoek, Keith S., primary, Taub, Dennis D., primary, Longo, Dan L., primary, Sondak, Vernon K., primary, Hewitt, Stephen M., primary, and Weeraratna, Ashani T., primary

Published
2023
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33. Supplementary Figure 4 from Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

Author

Dissanayake, Samudra K., primary, Olkhanud, Purevdorj B., primary, O'Connell, Michael P., primary, Carter, Arnell, primary, French, Amanda D., primary, Camilli, Tura C., primary, Emeche, Chineye D., primary, Hewitt, Kyle J., primary, Rosenthal, Devin T., primary, Leotlela, Poloko D., primary, Wade, Michael S., primary, Yang, Sherry W., primary, Brant, Larry, primary, Nickoloff, Brian J., primary, Messina, Jane L., primary, Biragyn, Arya, primary, Hoek, Keith S., primary, Taub, Dennis D., primary, Longo, Dan L., primary, Sondak, Vernon K., primary, Hewitt, Stephen M., primary, and Weeraratna, Ashani T., primary

Published
2023
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36. Data from PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression

Author

Paraiso, Kim H.T., primary, Xiang, Yun, primary, Rebecca, Vito W., primary, Abel, Ethan V., primary, Chen, Y. Ann, primary, Munko, A. Cecilia, primary, Wood, Elizabeth, primary, Fedorenko, Inna V., primary, Sondak, Vernon K., primary, Anderson, Alexander R.A., primary, Ribas, Antoni, primary, Palma, Maurizia Dalla, primary, Nathanson, Katherine L., primary, Koomen, John M., primary, Messina, Jane L., primary, and Smalley, Keiran S.M., primary

Published
2023
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38. Supplementary Table 1 from Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

Author

Dissanayake, Samudra K., primary, Olkhanud, Purevdorj B., primary, O'Connell, Michael P., primary, Carter, Arnell, primary, French, Amanda D., primary, Camilli, Tura C., primary, Emeche, Chineye D., primary, Hewitt, Kyle J., primary, Rosenthal, Devin T., primary, Leotlela, Poloko D., primary, Wade, Michael S., primary, Yang, Sherry W., primary, Brant, Larry, primary, Nickoloff, Brian J., primary, Messina, Jane L., primary, Biragyn, Arya, primary, Hoek, Keith S., primary, Taub, Dennis D., primary, Longo, Dan L., primary, Sondak, Vernon K., primary, Hewitt, Stephen M., primary, and Weeraratna, Ashani T., primary

Published
2023
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39. Supplementary Figure 5 from Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

Author

Dissanayake, Samudra K., primary, Olkhanud, Purevdorj B., primary, O'Connell, Michael P., primary, Carter, Arnell, primary, French, Amanda D., primary, Camilli, Tura C., primary, Emeche, Chineye D., primary, Hewitt, Kyle J., primary, Rosenthal, Devin T., primary, Leotlela, Poloko D., primary, Wade, Michael S., primary, Yang, Sherry W., primary, Brant, Larry, primary, Nickoloff, Brian J., primary, Messina, Jane L., primary, Biragyn, Arya, primary, Hoek, Keith S., primary, Taub, Dennis D., primary, Longo, Dan L., primary, Sondak, Vernon K., primary, Hewitt, Stephen M., primary, and Weeraratna, Ashani T., primary

Published
2023
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40. Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy

Author

Li, Jiannong, primary, Smalley, Inna, additional, Chen, Zhihua, additional, Wu, Jheng-Yu, additional, Phadke, Manali S., additional, Teer, Jamie K., additional, Nguyen, Thanh, additional, Karreth, Florian A., additional, Koomen, John M., additional, Sarnaik, Amod A., additional, Zager, Jonathan S., additional, Khushalani, Nikhil I., additional, Tarhini, Ahmad A., additional, Sondak, Vernon K., additional, Rodriguez, Paulo C., additional, Messina, Jane L., additional, Chen, Y. Ann, additional, and Smalley, Keiran S.M., additional

Published
2022
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41. Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma

Author

Song, Xiaofei, primary, Chang, Shiun, additional, Seminario-Vidal, Lucia, additional, de Mingo Pulido, Alvaro, additional, Tordesillas, Leticia, additional, Song, Xingzhi, additional, Reed, Rhianna A., additional, Harkins, Andrea, additional, Whiddon, Shannen, additional, Nguyen, Jonathan V., additional, Segura, Carlos Moran, additional, Zhang, Chaomei, additional, Yoder, Sean, additional, Sayegh, Zena, additional, Zhao, Yun, additional, Messina, Jane L., additional, Harro, Carly M., additional, Zhang, Xiaohui, additional, Conejo-Garcia, José R., additional, Berglund, Anders, additional, Sokol, Lubomir, additional, Zhang, Jianhua, additional, Rodriguez, Paulo C., additional, Mulé, James J., additional, Futreal, Andrew P., additional, Tsai, Kenneth Y., additional, and Chen, Pei-Ling, additional

Published
2022
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42. Cutaneous Human Papillomaviruses and the Risk of Keratinocyte Carcinomas

Author

Rollison, Dana E., primary, Amorrortu, Rossybelle P., additional, Zhao, Yayi, additional, Messina, Jane L., additional, Schell, Michael J., additional, Fenske, Neil A., additional, Cherpelis, Basil S., additional, Giuliano, Anna R., additional, Sondak, Vernon K., additional, Pawlita, Michael, additional, McKay-Chopin, Sandrine, additional, Gheit, Tarik, additional, Waterboer, Tim, additional, and Tommasino, Massimo, additional

Published
2021
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44. Association between Human Polyomaviruses and Keratinocyte Carcinomas: A Prospective Cohort Study

Author

Amorrortu, Rossybelle P., primary, Zhao, Yayi, additional, Messina, Jane L., additional, Schell, Michael J., additional, Fenske, Neil A., additional, Cherpelis, Basil S., additional, Sondak, Vernon K., additional, Giuliano, Anna R., additional, Pawlita, Michael, additional, McKay-Chopin, Sandrine, additional, Gheit, Tarik, additional, Waterboer, Tim, additional, Tommasino, Massimo, additional, and Rollison, Dana E., additional

Published
2021
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45. Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases

Author

Smalley, Inna, primary, Chen, Zhihua, additional, Phadke, Manali, additional, Li, Jiannong, additional, Yu, Xiaoqing, additional, Wyatt, Clayton, additional, Evernden, Brittany, additional, Messina, Jane L., additional, Sarnaik, Amod, additional, Sondak, Vernon K., additional, Zhang, Chaomei, additional, Law, Vincent, additional, Tran, Nam, additional, Etame, Arnold, additional, Macaulay, Robert J.B., additional, Eroglu, Zeynep, additional, Forsyth, Peter A., additional, Rodriguez, Paulo C., additional, Chen, Y. Ann, additional, and Smalley, Keiran S.M., additional

Published
2021
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48. Viruses in Skin Cancer (VIRUSCAN): Study Design and Baseline Characteristics of a Prospective Clinic-Based Cohort Study

Author

Amorrortu, Rossybelle P., primary, Fenske, Neil A., additional, Cherpelis, Basil S., additional, Vijayan, Laxmi, additional, Zhao, Yayi, additional, Balliu, Juliana, additional, Messina, Jane L., additional, Sondak, Vernon K., additional, Giuliano, Anna R., additional, Waterboer, Tim, additional, Pawlita, Michael, additional, Gheit, Tarik, additional, Tommasino, Massimo, additional, and Rollison, Dana E., additional

Published
2020
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49. Abstract B24: Using L-fucose to render melanomas immune hot: Roles of melanoma HLA-DRB1 and CD4+T cell-mediated antitumor immunity

Author

Daniel K. Lester, Kerri L. Thomas, Joseph Markowitz, Eric Lau, Kodumudi Krithika, Williamson Danial, Pasquale Innamorato, Matt Mercurio, Watson Gregory, Pilon-Thomas Shari, Messina Jane, Susan McCarthy, and Robert S. Haltiwanger

Subjects
Cancer Research, Antitumor immunity, Cd4 t cell, Melanoma, Immunology, Biology, medicine.disease, Fucose, chemistry.chemical_compound, Immune system, chemistry, medicine, Cancer research, HLA-DRB1
Abstract

Responsiveness to immunotherapies is limited in melanoma to subsets of patients. Despite attempts to improve responsiveness to immunotherapies by testing combination therapies, patients often experience significant adverse events that require the termination of treatment. Although causes of nonresponsiveness remain unclear and the subject of active investigation, a commonality among refractory tumors is low pretreatment levels of tumor-infiltrating lymphocytes (TILs). Thus, studies aiming to elucidate the interactions between melanoma and immune cells and to increase TIL levels are anticipated to improve therapies. We previously reported that fucosylation (the post-translational modification of proteins with the dietary plant sugar L-fucose), is altered in melanoma. Increasing fucosylation levels in melanoma—genetically or with oral L-fucose—suppresses tumor growth, metastasis, and increases TILs in immune competent mouse models of melanoma (Lau et al., 2015). The mechanisms underlying how melanoma fucosylation appears to trigger antitumor immunity are unclear. Here, we identified TIL subpopulations triggered by fucosylation to mediate tumor suppression and a key molecular mechanism. In NRAS- and BRAF-mutant melanoma models, dietary L-fucose suppressed tumor growth by ~50-60% and increased TILs by ~10-50-fold. Of all TIL subpopulations examined, CD3+ T cells were most increased by L-fucose, doubling or increasing by 15-fold, in NRAS- or BRAF-mutant models, respectively. Depletion of CD4+ T cells abrogated L-fucose-triggered TIL increases and tumor suppression, indicating that CD4+ T cells are central for antitumor immune effects of L-fucose. We identified the Class II MHC protein HLA-DRB1 as expressed and fucosylated in melanoma cells and confirmed its requirement for L-fucose-triggered, CD4+ T cell-dependent tumor suppression in vivo. Roles of HLA-DRB1 fucosylation in melanoma, effects on CD4+ T cell biology, and how L-fucose can enhance immunotherapies will be discussed. Our studies highlight how L-fucose supplementation can render tumors “immune hot” and represents a potential therapeutic strategy for improving immunotherapies. Citation Format: Daniel K. Lester, Matt Mercurio, Pasquale Innamorato, Kodumudi Krithika, Williamson Danial, Watson Gregory, Pilon-Thomas Shari, Messina Jane, Kerri L. Thomas, Susan McCarthy, Joseph Markowitz, Robert Haltiwanger, Eric Lau. Using L-fucose to render melanomas immune hot: Roles of melanoma HLA-DRB1 and CD4+T cell-mediated antitumor immunity [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2019 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(3 Suppl):Abstract nr B24.

Published
2020
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50. The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy

Author

Knepper, Todd C., primary, Montesion, Meagan, additional, Russell, Jeffery S., additional, Sokol, Ethan S., additional, Frampton, Garrett M., additional, Miller, Vincent A., additional, Albacker, Lee A., additional, McLeod, Howard L., additional, Eroglu, Zeynep, additional, Khushalani, Nikhil I., additional, Sondak, Vernon K., additional, Messina, Jane L., additional, Schell, Michael J., additional, DeCaprio, James A., additional, Tsai, Kenneth Y., additional, and Brohl, Andrew S., additional

Published
2019
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