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Your search keyword '"Godelieve, Meunier"' showing total 5 results
Start Over Author "Godelieve, Meunier" Publisher american association for cancer research (aacr)
5 results on '"Godelieve, Meunier"'

1. Table S3 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Jean Soulier, François Sigaux, Hugues de Thé, Claude Gazin, Jean-Jacques Diaz, Emmanuelle Clappier, Hervé Dombret, André Baruchel, Jules P. Meijerink, Pieter Van Vlierberghe, Tom Taghon, Isabelle André-Schmutz, Gerben Menschaert, Wouter Van Loocke, Jessica G. Buijs-Gladdines, Willem K. Smits, Marika Pla, Lucie Hernandez, Godelieve Meunier, Delphine Briot, Gabriel Thérizols, Marc Delord, Samuel Quentin, Frédéric Catez, Eulalia Genesca, David Avran, Tiama El-Chaar, and Stéphanie Gachet

Abstract

Differentially Expressed Proteins Deleted versus non-deleted clones

Published
2023
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2. Table S5 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Jean Soulier, François Sigaux, Hugues de Thé, Claude Gazin, Jean-Jacques Diaz, Emmanuelle Clappier, Hervé Dombret, André Baruchel, Jules P. Meijerink, Pieter Van Vlierberghe, Tom Taghon, Isabelle André-Schmutz, Gerben Menschaert, Wouter Van Loocke, Jessica G. Buijs-Gladdines, Willem K. Smits, Marika Pla, Lucie Hernandez, Godelieve Meunier, Delphine Briot, Gabriel Thérizols, Marc Delord, Samuel Quentin, Frédéric Catez, Eulalia Genesca, David Avran, Tiama El-Chaar, and Stéphanie Gachet

Abstract

Differentially expressed genes in Xenograted T-ALL shSYNCRIP-SNHG5 versus ShCtrl

Published
2023
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3. Table S4 from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Jean Soulier, François Sigaux, Hugues de Thé, Claude Gazin, Jean-Jacques Diaz, Emmanuelle Clappier, Hervé Dombret, André Baruchel, Jules P. Meijerink, Pieter Van Vlierberghe, Tom Taghon, Isabelle André-Schmutz, Gerben Menschaert, Wouter Van Loocke, Jessica G. Buijs-Gladdines, Willem K. Smits, Marika Pla, Lucie Hernandez, Godelieve Meunier, Delphine Briot, Gabriel Thérizols, Marc Delord, Samuel Quentin, Frédéric Catez, Eulalia Genesca, David Avran, Tiama El-Chaar, and Stéphanie Gachet

Abstract

Differentially translated transcripts - translatome

Published
2023
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4. Supplementary Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Jean Soulier, François Sigaux, Hugues de Thé, Claude Gazin, Jean-Jacques Diaz, Emmanuelle Clappier, Hervé Dombret, André Baruchel, Jules P. Meijerink, Pieter Van Vlierberghe, Tom Taghon, Isabelle André-Schmutz, Gerben Menschaert, Wouter Van Loocke, Jessica G. Buijs-Gladdines, Willem K. Smits, Marika Pla, Lucie Hernandez, Godelieve Meunier, Delphine Briot, Gabriel Thérizols, Marc Delord, Samuel Quentin, Frédéric Catez, Eulalia Genesca, David Avran, Tiama El-Chaar, and Stéphanie Gachet

Abstract

Supp Fig. S1-6, Supp Tables S1-S3, Supp Methods and References

Published
2023
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5. Data from Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Author

Jean Soulier, François Sigaux, Hugues de Thé, Claude Gazin, Jean-Jacques Diaz, Emmanuelle Clappier, Hervé Dombret, André Baruchel, Jules P. Meijerink, Pieter Van Vlierberghe, Tom Taghon, Isabelle André-Schmutz, Gerben Menschaert, Wouter Van Loocke, Jessica G. Buijs-Gladdines, Willem K. Smits, Marika Pla, Lucie Hernandez, Godelieve Meunier, Delphine Briot, Gabriel Thérizols, Marc Delord, Samuel Quentin, Frédéric Catez, Eulalia Genesca, David Avran, Tiama El-Chaar, and Stéphanie Gachet

Abstract

Deletion of chromosome 6q is a well-recognized abnormality found in poor-prognosis T-cell acute lymphoblastic leukemia (T-ALL). Using integrated genomic approaches, we identified two candidate haploinsufficient genes contiguous at 6q14, SYNCRIP (encoding hnRNP-Q) and SNHG5 (that hosts snoRNAs), both involved in regulating RNA maturation and translation. Combined silencing of both genes, but not of either gene alone, accelerated leukemogeneis in a Tal1/Lmo1/Notch1-driven mouse model, demonstrating the tumor-suppressive nature of the two-gene region. Proteomic and translational profiling of cells in which we engineered a short 6q deletion by CRISPR/Cas9 genome editing indicated decreased ribosome and mitochondrial activities, suggesting that the resulting metabolic changes may regulate tumor progression. Indeed, xenograft experiments showed an increased leukemia-initiating cell activity of primary human leukemic cells upon coextinction of SYNCRIP and SNHG5. Our findings not only elucidate the nature of 6q deletion but also highlight the role of ribosomes and mitochondria in T-ALL tumor progression.Significance:The oncogenic role of 6q deletion in T-ALL has remained elusive since this chromosomal abnormality was first identified more than 40 years ago. We combined genomic analysis and functional models to show that the codeletion of two contiguous genes at 6q14 enhances malignancy through deregulation of a ribosome–mitochondria axis, suggesting the potential for therapeutic intervention.This article is highlighted in the In This Issue feature, p. 1494

Published
2023
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