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Start Over Author "George E. Allen" Publisher american association for cancer research (aacr)
6 results on '"George E. Allen"'

1. Supplementary Table 2 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Soon Thye Lim, Bin Tean Teh, Patrick Tan, Steve Rozen, Choon Kiat Ong, Anna Gan, Hong Lee Heng, Vikneswari Rajasegaran, Cedric Chuan Young Ng, Willie Yu, Ioana Cutcutache, Christopher Goh, Daryl Tan, Lay Cheng Lim, Kuo Ann Lee, Swee Peng Yap, Kheng-Wei Yeoh, Susan Loong, Richard Quek, Miriam Tao, Kevin Tay, Whee Sze Ong, Soo Ching Chong, Leonard Tan, George E. Allen, Song Ling Poon, Tiffany Tang, Soo Yong Tan, and Ghee Chong Koo

Abstract

PDF file - 110K, Non-synonymous somatic mutations identified in the Discovery set of four NKTCL cases

Published
2023

2. Supplementary Table 3 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Soon Thye Lim, Bin Tean Teh, Patrick Tan, Steve Rozen, Choon Kiat Ong, Anna Gan, Hong Lee Heng, Vikneswari Rajasegaran, Cedric Chuan Young Ng, Willie Yu, Ioana Cutcutache, Christopher Goh, Daryl Tan, Lay Cheng Lim, Kuo Ann Lee, Swee Peng Yap, Kheng-Wei Yeoh, Susan Loong, Richard Quek, Miriam Tao, Kevin Tay, Whee Sze Ong, Soo Ching Chong, Leonard Tan, George E. Allen, Song Ling Poon, Tiffany Tang, Soo Yong Tan, and Ghee Chong Koo

Abstract

PDF file - 83K, JAK1 and JAK3 mutation status in NKTCL cases

Published
2023

3. Supplementary Table 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Soon Thye Lim, Bin Tean Teh, Patrick Tan, Steve Rozen, Choon Kiat Ong, Anna Gan, Hong Lee Heng, Vikneswari Rajasegaran, Cedric Chuan Young Ng, Willie Yu, Ioana Cutcutache, Christopher Goh, Daryl Tan, Lay Cheng Lim, Kuo Ann Lee, Swee Peng Yap, Kheng-Wei Yeoh, Susan Loong, Richard Quek, Miriam Tao, Kevin Tay, Whee Sze Ong, Soo Ching Chong, Leonard Tan, George E. Allen, Song Ling Poon, Tiffany Tang, Soo Yong Tan, and Ghee Chong Koo

Abstract

PDF file - 75K, Sequence analysis summary of tumor and blood samples from four NKTCL cases

Published
2023

4. Supplementary Table 4 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Soon Thye Lim, Bin Tean Teh, Patrick Tan, Steve Rozen, Choon Kiat Ong, Anna Gan, Hong Lee Heng, Vikneswari Rajasegaran, Cedric Chuan Young Ng, Willie Yu, Ioana Cutcutache, Christopher Goh, Daryl Tan, Lay Cheng Lim, Kuo Ann Lee, Swee Peng Yap, Kheng-Wei Yeoh, Susan Loong, Richard Quek, Miriam Tao, Kevin Tay, Whee Sze Ong, Soo Ching Chong, Leonard Tan, George E. Allen, Song Ling Poon, Tiffany Tang, Soo Yong Tan, and Ghee Chong Koo

Abstract

PDF file - 74K, Primer sets used for Sanger sequencing and HRM analysis

Published
2023

5. Supplementary Figure 1 from Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Soon Thye Lim, Bin Tean Teh, Patrick Tan, Steve Rozen, Choon Kiat Ong, Anna Gan, Hong Lee Heng, Vikneswari Rajasegaran, Cedric Chuan Young Ng, Willie Yu, Ioana Cutcutache, Christopher Goh, Daryl Tan, Lay Cheng Lim, Kuo Ann Lee, Swee Peng Yap, Kheng-Wei Yeoh, Susan Loong, Richard Quek, Miriam Tao, Kevin Tay, Whee Sze Ong, Soo Ching Chong, Leonard Tan, George E. Allen, Song Ling Poon, Tiffany Tang, Soo Yong Tan, and Ghee Chong Koo

Abstract

PDF file - 185K, Representative HRM curves of a NKTCL case confirmed as heterozygous JAK3A573V mutation

Published
2023

6. Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

Author

Tiffany Tang, Steve Rozen, Patrick Tan, Song Ling Poon, Choon Kiat Ong, Daryl Tan, Vikneswari Rajasegaran, Leonard Tan, Bin Tean Teh, Ghee Chong Koo, Ioana Cutcutache, Swee Peng Yap, Soon Thye Lim, Whee Sze Ong, Lay Cheng Lim, Christopher Goh, Richard Quek, Kuo Ann Lee, Anna Gan, Kheng-Wei Yeoh, Cedric Chuan Young Ng, Miriam Tao, Kevin Tay, Susan Loong, Willie Yu, George E. Allen, Hong Lee Heng, Soo Yong Tan, and Soo Ching Chong

Subjects
Adult, Male, Blotting, Western, DNA Mutational Analysis, Gene mutation, Lymphoma, T-Cell, medicine.disease_cause, symbols.namesake, Piperidines, Cell Line, Tumor, STAT5 Transcription Factor, medicine, Animals, Humans, Pyrroles, Phosphorylation, Exome sequencing, STAT5, Aged, Cell Proliferation, Aged, 80 and over, Sanger sequencing, Mutation, biology, Janus kinase 3, Janus Kinase 3, JAK-STAT signaling pathway, Middle Aged, Natural killer T cell, Molecular biology, Enzyme Activation, Pyrimidines, Oncology, biology.protein, symbols, Natural Killer T-Cells, Female, RNA Interference
Abstract

The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified Janus kinase 3 (JAK3) somatic–activating mutations (A572V and A573V) in 2 of 4 patients with NKTCLs. Further validation of the prevalence of JAK3 mutations was determined by Sanger sequencing and high-resolution melt (HRM) analysis in an additional 61 cases. In total, 23 of 65 (35.4%) cases harbored JAK3 mutations. Functional characterization of the JAK3 mutations support its involvement in cytokine-independent JAK/STAT constitutive activation leading to increased cell growth. Moreover, treatment of both JAK3-mutant and wild-type NKTCL cell lines with a novel pan-JAK inhibitor, CP-690550, resulted in dose-dependent reduction of phosphorylated STAT5, reduced cell viability, and increased apoptosis. Hence, targeting the deregulated JAK/STAT pathway could be a promising therapy for patients with NKTCLs. Significance: Gene mutations causing NKTCL have not been fully identified. Through exome sequencing, we identified activating mutations of JAK3 that may play a significant role in the pathogenesis of NKTCLs. Our findings have important implications for the management of patients with NKTCLs. Cancer Discov; 2(7); 591–7. ©2012 AACR. This article is highlighted in the In This Issue feature, p. 569.

Published
2012

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