Author: "Gad, A" / Publisher: american association for cancer research (aacr) - Searchworks@Jio Institute Digital Library Search Results

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1,389 results on '"Gad, A"'

1. Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma

Author: Kazandjian, Dickran, primary, Diamond, Benjamin, additional, Papadimitriou, Marios, additional, Hill, Elizabeth, additional, Sklavenitis-Pistofidis, Romanos, additional, Ziccheddu, Bachisio, additional, Blaney, Patrick, additional, Chojnacka, Monika, additional, Durante, Michael, additional, Maclachlan, Kylee, additional, Young, Ryan, additional, Usmani, Saad, additional, Davies, Faith, additional, Getz, Gad, additional, Ghobrial, Irene, additional, Korde, Neha, additional, Morgan, Gareth, additional, Maura, Francesco, additional, and Landgren, Ola, additional
Published: 2024
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2. Abstract P01: Impact of Germline and Somatic ATM Variants in Chronic Lymphocytic Leukemia (CLL): Clinical Implications and Response to PARP Inhibition

Author: Mashima, Kiyomi, primary, Moore, Nicholas, additional, Mikhaleva, Mariia, additional, Petráčková, Anna, additional, Shupe, Samantha, additional, Fernandes, Stacey M, additional, Taylor-Weiner, Amaro, additional, Gillani, Riaz, additional, Chu, Hoyin, additional, Han, Seunghun, additional, Camp, Sabrina, additional, Kofman, Eric, additional, Getz, Gad, additional, Wu, Catherine J., additional, Tyekucheva, Svitlana, additional, Davids, Matthew S, additional, Van Allen, Eliezer Mendel, additional, AlDubayan, Saud, additional, and Brown, Jennifer R, additional
Published: 2024
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3. Round Table Discussion on Optimal Clinical Trial Design in Precursor Multiple Myeloma

Author: Ghobrial, Irene M., primary, Gormley, Nicole, additional, Kumar, Shaji K., additional, Mateos, Maria-Victoria, additional, Bergsagel, P. Leif, additional, Chesi, Marta, additional, Dhodapkar, Madhav V., additional, Dispenzieri, Angela, additional, Fonseca, Rafael, additional, Getz, Gad, additional, Kastritis, Efstathios, additional, Kristinsson, Sigurdur Y., additional, Martinez-Climent, Jose Angel, additional, Manier, Salomon, additional, Marinac, Catherine R., additional, Maura, Francesco, additional, Morgan, Gareth J., additional, Davies, Faith E., additional, Nadeem, Omar, additional, Nuvolone, Mario, additional, Paiva, Bruno, additional, O’Donnell, Elizabeth, additional, Prosper, Felipe, additional, Shah, Urvi A., additional, Sklavenitis-Pistofidis, Romanos, additional, Sperling, Adam S., additional, Vassiliou, George S., additional, Munshi, Nikhil C., additional, Castle, Philip E., additional, Anderson, Kenneth C., additional, and San Miguel, Jesus F., additional
Published: 2024
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4. Supplementary Methods from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
Full Text: View/download PDF

5. Supplementary Table 2 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
Full Text: View/download PDF

6. Supplementary Figure 4 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
Full Text: View/download PDF

7. Supplementary Table S6 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies

Author: Li, Yafang, primary, Xiao, Xiangjun, primary, Li, Jianrong, primary, Han, Younghun, primary, Cheng, Chao, primary, Fernandes, Gail F., primary, Slewitzke, Shannon E., primary, Rosenberg, Susan M., primary, Zhu, Meng, primary, Byun, Jinyoung, primary, Bossé, Yohan, primary, McKay, James D., primary, Albanes, Demetrios, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria T., primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Christiani, David C., primary, Rennert, Gad, primary, Arnold, Susanne M., primary, Goodman, Gary E., primary, Field, John K., primary, Davies, Michael P.A., primary, Shete, Sanjay, primary, Marchand, Loïc Le, primary, Liu, Geoffrey, primary, Hung, Rayjean J., primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Sun, Ryan, primary, Zienolddiny, Shanbeh, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Lazarus, Philip, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Schwartz, Ann G., primary, Gorlov, Ivan, primary, Purrington, Kristen S., primary, Yang, Ping, primary, Liu, Yanhong, primary, Bailey-Wilson, Joan E., primary, Pinney, Susan M., primary, Mandal, Diptasri, primary, Willey, James C., primary, Gaba, Colette, primary, Brennan, Paul, primary, Xia, Jun, primary, Shen, Hongbing, primary, and Amos, Christopher I., primary
Published: 2024
Full Text: View/download PDF

8. Data from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies

Author: Li, Yafang, primary, Xiao, Xiangjun, primary, Li, Jianrong, primary, Han, Younghun, primary, Cheng, Chao, primary, Fernandes, Gail F., primary, Slewitzke, Shannon E., primary, Rosenberg, Susan M., primary, Zhu, Meng, primary, Byun, Jinyoung, primary, Bossé, Yohan, primary, McKay, James D., primary, Albanes, Demetrios, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria T., primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Christiani, David C., primary, Rennert, Gad, primary, Arnold, Susanne M., primary, Goodman, Gary E., primary, Field, John K., primary, Davies, Michael P.A., primary, Shete, Sanjay, primary, Marchand, Loïc Le, primary, Liu, Geoffrey, primary, Hung, Rayjean J., primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Sun, Ryan, primary, Zienolddiny, Shanbeh, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Lazarus, Philip, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Schwartz, Ann G., primary, Gorlov, Ivan, primary, Purrington, Kristen S., primary, Yang, Ping, primary, Liu, Yanhong, primary, Bailey-Wilson, Joan E., primary, Pinney, Susan M., primary, Mandal, Diptasri, primary, Willey, James C., primary, Gaba, Colette, primary, Brennan, Paul, primary, Xia, Jun, primary, Shen, Hongbing, primary, and Amos, Christopher I., primary
Published: 2024
Full Text: View/download PDF

9. Figure S4 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies

Author: Li, Yafang, primary, Xiao, Xiangjun, primary, Li, Jianrong, primary, Han, Younghun, primary, Cheng, Chao, primary, Fernandes, Gail F., primary, Slewitzke, Shannon E., primary, Rosenberg, Susan M., primary, Zhu, Meng, primary, Byun, Jinyoung, primary, Bossé, Yohan, primary, McKay, James D., primary, Albanes, Demetrios, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria T., primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Christiani, David C., primary, Rennert, Gad, primary, Arnold, Susanne M., primary, Goodman, Gary E., primary, Field, John K., primary, Davies, Michael P.A., primary, Shete, Sanjay, primary, Marchand, Loïc Le, primary, Liu, Geoffrey, primary, Hung, Rayjean J., primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Sun, Ryan, primary, Zienolddiny, Shanbeh, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Lazarus, Philip, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Schwartz, Ann G., primary, Gorlov, Ivan, primary, Purrington, Kristen S., primary, Yang, Ping, primary, Liu, Yanhong, primary, Bailey-Wilson, Joan E., primary, Pinney, Susan M., primary, Mandal, Diptasri, primary, Willey, James C., primary, Gaba, Colette, primary, Brennan, Paul, primary, Xia, Jun, primary, Shen, Hongbing, primary, and Amos, Christopher I., primary
Published: 2024
Full Text: View/download PDF

10. Data from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
Full Text: View/download PDF

11. Supplementary Table 1 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
Full Text: View/download PDF

12. Supplementary Figure 1 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
Full Text: View/download PDF

13. Supplementary Figure 2 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
Full Text: View/download PDF

14. Supplementary Figure 3 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
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15. Supplementary Figure 5 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, primary, Kim, Andre E., primary, Obón-Santacana, Mireia, primary, Moratalla-Navarro, Ferran, primary, Martín, Vicente, primary, Moreno, Victor, primary, Lin, Yi, primary, Bien, Stephanie A., primary, Qu, Conghui, primary, Su, Yu-Ru, primary, White, Emily, primary, Harrison, Tabitha A., primary, Huyghe, Jeroen R., primary, Tangen, Catherine M., primary, Newcomb, Polly A., primary, Phipps, Amanda I., primary, Thomas, Claire E., primary, Kawaguchi, Eric S., primary, Lewinger, Juan Pablo, primary, Morrison, John L., primary, Conti, David V., primary, Wang, Jun, primary, Thomas, Duncan C., primary, Platz, Elizabeth A., primary, Visvanathan, Kala, primary, Keku, Temitope O., primary, Newton, Christina C., primary, Um, Caroline Y., primary, Kundaje, Anshul, primary, Shcherbina, Anna, primary, Murphy, Neil, primary, Gunter, Marc J., primary, Dimou, Niki, primary, Papadimitriou, Nikos, primary, Bézieau, Stéphane, primary, van Duijnhoven, Franzel J.B., primary, Männistö, Satu, primary, Rennert, Gad, primary, Wolk, Alicja, primary, Hoffmeister, Michael, primary, Brenner, Hermann, primary, Chang-Claude, Jenny, primary, Tian, Yu, primary, Le Marchand, Loïc, primary, Cotterchio, Michelle, primary, Tsilidis, Konstantinos K., primary, Bishop, D. Timothy, primary, Melaku, Yohannes Adama, primary, Lynch, Brigid M., primary, Buchanan, Daniel D., primary, Ulrich, Cornelia M., primary, Ose, Jennifer, primary, Peoples, Anita R., primary, Pellatt, Andrew J., primary, Li, Li, primary, Devall, Matthew A.M., primary, Campbell, Peter T., primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Berndt, Sonja I., primary, Gruber, Stephen B., primary, Ruiz-Narvaez, Edward, primary, Song, Mingyang, primary, Joshi, Amit D., primary, Drew, David A., primary, Petrick, Jessica L., primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Peters, Ulrike, primary, Hsu, Li, primary, and Gauderman, W. James, primary
Published: 2024
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16. Supplementary Materials from CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility

Author: Du, Mulong, primary, Xin, Junyi, primary, Zheng, Rui, primary, Yuan, Qianyu, primary, Wang, Zhihui, primary, Liu, Hongliang, primary, Liu, Hanting, primary, Cai, Guoshuai, primary, Albanes, Demetrius, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria Teresa, primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Rennert, Gad, primary, Arnold, Susanne, primary, Brennan, Paul, primary, Field, John K., primary, Shete, Sanjay S., primary, Le Marchand, Loïc, primary, Liu, Geoffrey, primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Zienolddiny, Shan, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Yuan, Jian-Min, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Wang, Meilin, primary, Shen, Hongbing, primary, Chen, Feng, primary, Zhang, Zhengdong, primary, Hung, Rayjean J., primary, Amos, Christopher I., primary, Wei, Qingyi, primary, Lazarus, Philip, primary, and Christiani, David C., primary
Published: 2024
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17. Data from CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility

Author: Du, Mulong, primary, Xin, Junyi, primary, Zheng, Rui, primary, Yuan, Qianyu, primary, Wang, Zhihui, primary, Liu, Hongliang, primary, Liu, Hanting, primary, Cai, Guoshuai, primary, Albanes, Demetrius, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria Teresa, primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Rennert, Gad, primary, Arnold, Susanne, primary, Brennan, Paul, primary, Field, John K., primary, Shete, Sanjay S., primary, Le Marchand, Loïc, primary, Liu, Geoffrey, primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Zienolddiny, Shan, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Yuan, Jian-Min, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Wang, Meilin, primary, Shen, Hongbing, primary, Chen, Feng, primary, Zhang, Zhengdong, primary, Hung, Rayjean J., primary, Amos, Christopher I., primary, Wei, Qingyi, primary, Lazarus, Philip, primary, and Christiani, David C., primary
Published: 2024
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18. Supplementary Tables1-11 from CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility

Author: Du, Mulong, primary, Xin, Junyi, primary, Zheng, Rui, primary, Yuan, Qianyu, primary, Wang, Zhihui, primary, Liu, Hongliang, primary, Liu, Hanting, primary, Cai, Guoshuai, primary, Albanes, Demetrius, primary, Lam, Stephen, primary, Tardon, Adonina, primary, Chen, Chu, primary, Bojesen, Stig E., primary, Landi, Maria Teresa, primary, Johansson, Mattias, primary, Risch, Angela, primary, Bickeböller, Heike, primary, Wichmann, H-Erich, primary, Rennert, Gad, primary, Arnold, Susanne, primary, Brennan, Paul, primary, Field, John K., primary, Shete, Sanjay S., primary, Le Marchand, Loïc, primary, Liu, Geoffrey, primary, Andrew, Angeline S., primary, Kiemeney, Lambertus A., primary, Zienolddiny, Shan, primary, Grankvist, Kjell, primary, Johansson, Mikael, primary, Caporaso, Neil E., primary, Cox, Angela, primary, Hong, Yun-Chul, primary, Yuan, Jian-Min, primary, Schabath, Matthew B., primary, Aldrich, Melinda C., primary, Wang, Meilin, primary, Shen, Hongbing, primary, Chen, Feng, primary, Zhang, Zhengdong, primary, Hung, Rayjean J., primary, Amos, Christopher I., primary, Wei, Qingyi, primary, Lazarus, Philip, primary, and Christiani, David C., primary
Published: 2024
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19. Supplementary Figures S1-S5 from Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium

Author: Das, Anirban, primary, Fernandez, Nicholas R., primary, Levine, Adrian, primary, Bianchi, Vanessa, primary, Stengs, Lucie K., primary, Chung, Jiil, primary, Negm, Logine, primary, Dimayacyac, Jose Rafael, primary, Chang, Yuan, primary, Nobre, Liana, primary, Ercan, Ayse B., primary, Sanchez-Ramirez, Santiago, primary, Sudhaman, Sumedha, primary, Edwards, Melissa, primary, Larouche, Valerie, primary, Samuel, David, primary, Van Damme, An, primary, Gass, David, primary, Ziegler, David S., primary, Bielack, Stefan S., primary, Koschmann, Carl, primary, Zelcer, Shayna, primary, Yalon-Oren, Michal, primary, Campino, Gadi Abede, primary, Sarosiek, Tomasz, primary, Nichols, Kim E., primary, Loret De Mola, Rebecca, primary, Bielamowicz, Kevin, primary, Sabel, Magnus, primary, Frojd, Charlotta A., primary, Wood, Matthew D., primary, Glover, Jason M., primary, Lee, Yi-Yen, primary, Vanan, Magimairajan, primary, Adamski, Jenny K., primary, Perreault, Sebastien, primary, Chamdine, Omar, primary, Hjort, Magnus Aasved, primary, Zapotocky, Michal, primary, Carceller, Fernando, primary, Wright, Erin, primary, Fedorakova, Ivana, primary, Lossos, Alexander, primary, Tanaka, Ryuma, primary, Osborn, Michael, primary, Blumenthal, Deborah T., primary, Aronson, Melyssa, primary, Bartels, Ute, primary, Huang, Annie, primary, Ramaswamy, Vijay, primary, Malkin, David, primary, Shlien, Adam, primary, Villani, Anita, primary, Dirks, Peter B., primary, Pugh, Trevor J., primary, Getz, Gad, primary, Maruvka, Yosef E., primary, Tsang, Derek S., primary, Ertl-Wagner, Birgit, primary, Hawkins, Cynthia, primary, Bouffet, Eric, primary, Morgenstern, Daniel A., primary, and Tabori, Uri, primary
Published: 2024
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20. Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium

Author: Das, Anirban, primary, Fernandez, Nicholas R., additional, Levine, Adrian, additional, Bianchi, Vanessa, additional, Stengs, Lucie K., additional, Chung, Jiil, additional, Negm, Logine, additional, Dimayacyac, Jose Rafael, additional, Chang, Yuan, additional, Nobre, Liana, additional, Ercan, Ayse B., additional, Sanchez-Ramirez, Santiago, additional, Sudhaman, Sumedha, additional, Edwards, Melissa, additional, Larouche, Valerie, additional, Samuel, David, additional, Van Damme, An, additional, Gass, David, additional, Ziegler, David S., additional, Bielack, Stefan S., additional, Koschmann, Carl, additional, Zelcer, Shayna, additional, Yalon-Oren, Michal, additional, Campino, Gadi Abede, additional, Sarosiek, Tomasz, additional, Nichols, Kim E., additional, Loret De Mola, Rebecca, additional, Bielamowicz, Kevin, additional, Sabel, Magnus, additional, Frojd, Charlotta A., additional, Wood, Matthew D., additional, Glover, Jason M., additional, Lee, Yi-Yen, additional, Vanan, Magimairajan, additional, Adamski, Jenny K., additional, Perreault, Sebastien, additional, Chamdine, Omar, additional, Hjort, Magnus Aasved, additional, Zapotocky, Michal, additional, Carceller, Fernando, additional, Wright, Erin, additional, Fedorakova, Ivana, additional, Lossos, Alexander, additional, Tanaka, Ryuma, additional, Osborn, Michael, additional, Blumenthal, Deborah T., additional, Aronson, Melyssa, additional, Bartels, Ute, additional, Huang, Annie, additional, Ramaswamy, Vijay, additional, Malkin, David, additional, Shlien, Adam, additional, Villani, Anita, additional, Dirks, Peter B., additional, Pugh, Trevor J., additional, Getz, Gad, additional, Maruvka, Yosef E., additional, Tsang, Derek S., additional, Ertl-Wagner, Birgit, additional, Hawkins, Cynthia, additional, Bouffet, Eric, additional, Morgenstern, Daniel A., additional, and Tabori, Uri, additional
Published: 2024
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21. Abstract A023: High glucose increases DNA damage and elevates the expression of multiple DDR genes

Author: Rahmoon, Mai A., primary, Elghaish, Reem A., additional, Ibrahim, Aya A., additional, Alaswad, Zina, additional, Gad, Mohamed Z., additional, El-Khamisy, Sherif F., additional, and Elserafy, Menattallah, additional
Published: 2024
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22. Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies

Author: Li, Yafang, primary, Xiao, Xiangjun, additional, Li, Jianrong, additional, Han, Younghun, additional, Cheng, Chao, additional, Fernandes, Gail F., additional, Slewitzke, Shannon E., additional, Rosenberg, Susan M., additional, Zhu, Meng, additional, Byun, Jinyoung, additional, Bossé, Yohan, additional, McKay, James D., additional, Albanes, Demetrios, additional, Lam, Stephen, additional, Tardon, Adonina, additional, Chen, Chu, additional, Bojesen, Stig E., additional, Landi, Maria T., additional, Johansson, Mattias, additional, Risch, Angela, additional, Bickeböller, Heike, additional, Wichmann, H-Erich, additional, Christiani, David C., additional, Rennert, Gad, additional, Arnold, Susanne M., additional, Goodman, Gary E., additional, Field, John K., additional, Davies, Michael P.A., additional, Shete, Sanjay, additional, Marchand, Loïc Le, additional, Liu, Geoffrey, additional, Hung, Rayjean J., additional, Andrew, Angeline S., additional, Kiemeney, Lambertus A., additional, Sun, Ryan, additional, Zienolddiny, Shanbeh, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Caporaso, Neil E., additional, Cox, Angela, additional, Hong, Yun-Chul, additional, Lazarus, Philip, additional, Schabath, Matthew B., additional, Aldrich, Melinda C., additional, Schwartz, Ann G., additional, Gorlov, Ivan, additional, Purrington, Kristen S., additional, Yang, Ping, additional, Liu, Yanhong, additional, Bailey-Wilson, Joan E., additional, Pinney, Susan M., additional, Mandal, Diptasri, additional, Willey, James C., additional, Gaba, Colette, additional, Brennan, Paul, additional, Xia, Jun, additional, Shen, Hongbing, additional, and Amos, Christopher I., additional
Published: 2024
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23. CYP2A6 activity and cigarette consumption interact in smoking-related lung cancer susceptibility

Author: Du, Mulong, primary, Xin, Junyi, additional, Zheng, Rui, additional, Yuan, Qianyu, additional, Wang, Zhihui, additional, Liu, Hongliang, additional, Liu, Hanting, additional, Cai, Guoshuai, additional, Albanes, Demetrius, additional, Lam, Stephen, additional, Tardon, Adonina, additional, Chen, Chu, additional, Bojesen, Stig E., additional, Landi, Maria Teresa, additional, Johansson, Mattias, additional, Risch, Angela, additional, Bickeböller, Heike, additional, Wichmann, H-Erich, additional, Rennert, Gad, additional, Arnold, Susanne, additional, Brennan, Paul, additional, Field, John K., additional, Shete, Sanjay S., additional, Le Marchand, Loïc, additional, Liu, Geoffrey, additional, Andrew, Angeline S., additional, Kiemeney, Lambertus A., additional, Zienolddiny, Shanbeh, additional, Grankvist, Kjell, additional, Johansson, Mikael, additional, Caporaso, Neil E., additional, Cox, Angela, additional, Hong, Yun-Chul, additional, Yuan, Jian-Min, additional, Schabath, Matthew B., additional, Aldrich, Melinda C., additional, Wang, Meilin, additional, Shen, Hongbing, additional, Chen, Feng, additional, Zhang, Zhengdong, additional, Hung, Rayjean J., additional, Amos, Christopher I., additional, Wei, Qingyi, additional, Lazarus, Philip, additional, and Christiani, David C., additional
Published: 2023
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24. Genome-wide gene-environment interaction analyses to understand the relationship between red meat and processed meat intake and colorectal cancer risk.

Author: Stern, Mariana C., primary, Sanchez Mendez, Joel, additional, Kim, Andre E., additional, Obón-Santacana, Mireia, additional, Moratalla-Navarro, Ferran, additional, Martín, Vicente, additional, Moreno, Victor, additional, Lin, Yi, additional, Bien, Stephanie A., additional, Qu, Conghui, additional, Su, Yu-Ru, additional, White, Emily, additional, Harrison, Tabitha A., additional, Huyghe, Jeroen R., additional, Tangen, Catherine M., additional, Newcomb, Polly A., additional, Phipps, Amanda I., additional, Thomas, Claire E., additional, Kawaguchi, Eric S., additional, Lewinger, Juan Pablo, additional, Morrison, John L., additional, Conti, David V., additional, Wang, Jun, additional, Thomas, Duncan C., additional, Platz, Elizabeth A., additional, Visvanathan, Kala, additional, Keku, Temitope O., additional, Newton, Christina C., additional, Um, Caroline Y., additional, Kundaje, Anshul, additional, Shcherbina, Anna, additional, Murphy, Neil, additional, Gunter, Marc J., additional, Dimou, Niki, additional, Papadimitriou, Nikos, additional, Bézieau, Stéphane, additional, van Duijnhoven, Fränzel JB., additional, Männistö, Satu, additional, Rennert, Gad, additional, Wolk, Alicja, additional, Hoffmeister, Michael, additional, Brenner, Hermann, additional, Chang-Claude, Jenny, additional, Tian, Yu, additional, Le Marchand, Loïc, additional, Cotterchio, Michelle, additional, Tsilidis, Konstantinos K., additional, Bishop, D Timothy Timothy., additional, Melaku, Yohannes Adama, additional, Lynch, Brigid M., additional, Buchanan, Daniel D., additional, Ulrich, Cornelia M., additional, Ose, Jennifer, additional, Peoples, Anita R., additional, Pellatt, Andrew J., additional, Li, Li, additional, Devall, Matthew AM., additional, Campbell, Peter T., additional, Albanes, Demetrius, additional, Weinstein, Stephanie J., additional, Berndt, Sonja I., additional, Gruber, Stephen B., additional, Ruiz-Narvaez, Edward, additional, Song, Mingyang, additional, Joshi, Amit D., additional, Drew, David A., additional, Petrick, Jessica L., additional, Chan, Andrew T., additional, Giannakis, Marios, additional, Peters, Ulrike, additional, Hsu, Li, additional, and Gauderman, W James, additional
Published: 2023
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25. FIGURE 1 from Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma

Author: Mouhieddine, Tarek H., primary, Nzerem, Chidimma, primary, Redd, Robert, primary, Dunford, Andrew, primary, Leventhal, Matthew, primary, Sklavenitis-Pistofidis, Romanos, primary, Tahri, Sabrin, primary, El-Khoury, Habib, primary, Steensma, David P., primary, Ebert, Benjamin L., primary, Soiffer, Robert J., primary, Keats, Jonathan J., primary, Mehr, Shaadi, primary, Auclair, Daniel, primary, Ghobrial, Irene M., primary, Sperling, Adam S., primary, Stewart, Chip, primary, and Getz, Gad, primary
Published: 2023
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26. Supplementary Table 3 from Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma

Author: Mouhieddine, Tarek H., primary, Nzerem, Chidimma, primary, Redd, Robert, primary, Dunford, Andrew, primary, Leventhal, Matthew, primary, Sklavenitis-Pistofidis, Romanos, primary, Tahri, Sabrin, primary, El-Khoury, Habib, primary, Steensma, David P., primary, Ebert, Benjamin L., primary, Soiffer, Robert J., primary, Keats, Jonathan J., primary, Mehr, Shaadi, primary, Auclair, Daniel, primary, Ghobrial, Irene M., primary, Sperling, Adam S., primary, Stewart, Chip, primary, and Getz, Gad, primary
Published: 2023
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27. Supplementary Figure 3 from Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma

Author: Mouhieddine, Tarek H., primary, Nzerem, Chidimma, primary, Redd, Robert, primary, Dunford, Andrew, primary, Leventhal, Matthew, primary, Sklavenitis-Pistofidis, Romanos, primary, Tahri, Sabrin, primary, El-Khoury, Habib, primary, Steensma, David P., primary, Ebert, Benjamin L., primary, Soiffer, Robert J., primary, Keats, Jonathan J., primary, Mehr, Shaadi, primary, Auclair, Daniel, primary, Ghobrial, Irene M., primary, Sperling, Adam S., primary, Stewart, Chip, primary, and Getz, Gad, primary
Published: 2023
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28. Clinical outcomes and evolution of clonal hematopoiesis in patients with newly diagnosed multiple myeloma

Author: Mouhieddine, Tarek H, primary, Nzerem, Chidimma, additional, Redd, Robert, additional, Dunford, Andrew, additional, Leventhal, Matthew, additional, Sklavenitis-Pistofidis, Romanos, additional, Tahri, Sabrin, additional, El-Khoury, Habib, additional, Steensma, David P, additional, Ebert, Benjamin L., additional, Soiffer, Robert J., additional, Keats, Jonathan J, additional, Mehr, Shaadi, additional, Auclair, Daniel, additional, Ghobrial, Irene M, additional, Sperling, Adam S., additional, Stewart, Chip, additional, and Getz, Gad, additional
Published: 2023
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29. Supplementary Figures and Tables from MinimuMM-seq: Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma Pathology

Author: Dutta, Ankit K., primary, Alberge, Jean-Baptiste, primary, Lightbody, Elizabeth D., primary, Boehner, Cody J., primary, Dunford, Andrew, primary, Sklavenitis-Pistofidis, Romanos, primary, Mouhieddine, Tarek H., primary, Cowan, Annie N., primary, Su, Nang Kham, primary, Horowitz, Erica M., primary, Barr, Hadley, primary, Hevenor, Laura, primary, Beckwith, Jenna B., primary, Perry, Jacqueline, primary, Cao, Amanda, primary, Lin, Ziao, primary, Kuhr, Frank K., primary, Mastro, Richard G. Del, primary, Nadeem, Omar, primary, Greipp, Patricia T., primary, Stewart, Chip, primary, Auclair, Daniel, primary, Getz, Gad, primary, and Ghobrial, Irene M., primary
Published: 2023
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30. Data from MinimuMM-seq: Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma Pathology

Author: Dutta, Ankit K., primary, Alberge, Jean-Baptiste, primary, Lightbody, Elizabeth D., primary, Boehner, Cody J., primary, Dunford, Andrew, primary, Sklavenitis-Pistofidis, Romanos, primary, Mouhieddine, Tarek H., primary, Cowan, Annie N., primary, Su, Nang Kham, primary, Horowitz, Erica M., primary, Barr, Hadley, primary, Hevenor, Laura, primary, Beckwith, Jenna B., primary, Perry, Jacqueline, primary, Cao, Amanda, primary, Lin, Ziao, primary, Kuhr, Frank K., primary, Mastro, Richard G. Del, primary, Nadeem, Omar, primary, Greipp, Patricia T., primary, Stewart, Chip, primary, Auclair, Daniel, primary, Getz, Gad, primary, and Ghobrial, Irene M., primary
Published: 2023
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31. Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

Author: Varkaris, Andreas, primary, Fece de la Cruz, Ferran, additional, Martin, Elizabeth E., additional, Norden, Bryanna L., additional, Chevalier, Nicholas, additional, Kehlmann, Allison M., additional, Leshchiner, Ignaty, additional, Barnes, Haley, additional, Ehnstrom, Sara, additional, Stavridi, Anastasia-Maria, additional, Yuan, Xin, additional, Kim, Janice S., additional, Ellis, Haley, additional, Papatheodoridi, Alkistis, additional, Gunaydin, Hakan, additional, Danysh, Brian P., additional, Parida, Laxmi, additional, Sanidas, Ioannis, additional, Ji, Yongli, additional, Lau, Kayao, additional, Wulf, Gerburg M., additional, Bardia, Aditya, additional, Spring, Laura M., additional, Isakoff, Steven J., additional, Lennerz, Jochen K., additional, Del Vecchio, Kathryn, additional, Pierce, Levi, additional, Pazolli, Ermira, additional, Getz, Gad, additional, Corcoran, Ryan B., additional, and Juric, Dejan, additional
Published: 2023
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32. Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors

Author: Joseph Toker, J. Bryan Iorgulescu, Alexander L. Ling, Genaro R. Villa, Josephina A.M.A. Gadet, Laxmi Parida, Gad Getz, Catherine J. Wu, David A. Reardon, E. Antonio Chiocca, and Marco Mineo
Subjects: Cancer Research, Oncology
Abstract: Purpose: mAbs targeting the PD-1/PD-L1 immune checkpoint are powerful tools to improve the survival of patients with cancer. Understanding the molecular basis of clinical response to these treatments is critical to identify patients who can benefit from this immunotherapy. In this study, we investigated long noncoding RNA (lncRNA) expression in patients with cancer treated with anti-PD-1/PD-L1 immunotherapy. Experimental Design: lncRNA expression profile was analyzed in one cohort of patients with melanoma and two independent cohorts of patients with glioblastoma (GBM) undergoing anti-PD-1/PD-L1 immunotherapy. Single-cell RNA-sequencing analyses were performed to evaluate lncRNA expression in tumor cells and tumor-infiltrating immune cells. Results: We identified the lncRNA NEAT1 as commonly upregulated between patients with melanoma with complete therapeutic response and patients with GBM with longer survival following anti-PD-1/PD-L1 treatment. Gene set enrichment analyses revealed that NEAT1 expression was strongly associated with the IFNγ pathways, along with downregulation of cell-cycle-related genes. Single-cell RNA-sequencing analyses revealed NEAT1 expression across multiple cell types within the GBM microenvironment, including tumor cells, macrophages, and T cells. High NEAT1 expression levels in tumor cells correlated with increased infiltrating macrophages and microglia. In these tumor-infiltrating myeloid cells, we found that NEAT1 expression was linked to enrichment in TNFα/NFκB signaling pathway genes. Silencing NEAT1 suppressed M1 macrophage polarization and reduced the expression of TNFα and other inflammatory cytokines. Conclusions: These findings suggest an association between NEAT1 expression and patient response to anti-PD-1/PD-L1 therapy in melanoma and GBM and have important implications for the role of lncRNAs in the tumor microenvironment.
Published: 2023
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33. MinimuMM-seq: Genome Sequencing of Circulating Tumor Cells for Minimally Invasive Molecular Characterization of Multiple Myeloma Pathology

Author: Ankit K. Dutta, Jean-Baptiste Alberge, Elizabeth D. Lightbody, Cody J. Boehner, Andrew Dunford, Romanos Sklavenitis-Pistofidis, Tarek H. Mouhieddine, Annie N. Cowan, Nang Kham Su, Erica M. Horowitz, Hadley Barr, Laura Hevenor, Jenna B. Beckwith, Jacqueline Perry, Amanda Cao, Ziao Lin, Frank K. Kuhr, Richard G. Del Mastro, Omar Nadeem, Patricia T. Greipp, Chip Stewart, Daniel Auclair, Gad Getz, and Irene M. Ghobrial
Subjects: Oncology
Abstract: Abstract Multiple myeloma (MM) develops from well-defined precursor stages; however, invasive bone marrow (BM) biopsy limits screening and monitoring strategies for patients. We enumerated circulating tumor cells (CTC) from 261 patients (84 monoclonal gammopathy of undetermined significance, 155 smoldering multiple myeloma, and 22 MM), with neoplastic cells detected in 84%. We developed a novel approach, MinimuMM-seq, which enables the detection of translocations and copy-number abnormalities through whole-genome sequencing of highly pure CTCs. Application to CTCs in a cohort of 51 patients, 24 with paired BM, was able to detect 100% of clinically reported BM biopsy events and could replace molecular cytogenetics for diagnostic yield and risk classification. Longitudinal sampling of CTCs in 8 patients revealed major clones could be tracked in the blood, with clonal evolution and shifting dynamics of subclones over time. Our findings provide proof of concept that CTC detection and genomic profiling could be used clinically for monitoring and managing disease in MM. Significance: In this study, we established an approach enabling the enumeration and sequencing of CTCs to replace standard molecular cytogenetics. CTCs harbored the same pathognomonic MM abnormalities as BM plasma cells. Longitudinal sampling of serial CTCs was able to track clonal dynamics over time and detect the emergence of high-risk genetic subclones.
Published: 2023
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34. Abstract PR015: Tumor-specific immunity generated by a personalized neoantigen vaccination incorporating locally delivered ipilimumab in renal cell carcinoma

Author: Braun, David A., primary, Keskin, Derin B., additional, Shukla, Sachet A., additional, McGregor, Bradley A., additional, Schindler, Nicholas R., additional, Blass, Eryn, additional, Klaeger, Susan, additional, Pomerance, Lucas, additional, Sarkizova, Siranush, additional, Li, Shuqiang, additional, Southard, Jackson, additional, Moranzoni, Giorgia, additional, Pedersen, Christina B., additional, Liu, Yiwen, additional, Chang, Steven L., additional, Hirsch, Michelle S., additional, LeBoeuf, Nicole R., additional, Mossanen, Matthew, additional, Chea, Vipheaviny, additional, Carulli, Isabel, additional, Olive, Oriol, additional, Mehndiratta, Ambica, additional, Greenslade, Haley, additional, Oliveira, Giacomo, additional, Iorgulescu, J. Bryan, additional, Signoretti, Sabina, additional, Aster, Jon C., additional, Elagina, Liudmila, additional, Leshchiner, Ignaty, additional, Getz, Gad, additional, Harden, Maegan, additional, Gabriel, Stacey, additional, Olsen, Lars R., additional, Neuberg, Donna S., additional, Fritsch, Edward F., additional, Hacohen, Nir, additional, Livak, Kenneth J., additional, Carr, Steven, additional, Ott, Patrick A., additional, Wu, Catherine J., additional, and Choueiri, Toni K., additional
Published: 2023
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35. Abstract A013: Tumor-specific immunity generated by a personalized neoantigen vaccination incorporating locally delivered ipilimumab in renal cell carcinoma

Author: Braun, David A., primary, Keskin, Derin B., additional, Shukla, Sachet A., additional, McGregor, Bradley A., additional, Schindler, Nicholas R., additional, Blass, Eryn, additional, Klaeger, Susan, additional, Pomerance, Lucas, additional, Sarkizova, Siranush, additional, Li, Shuqiang, additional, Southard, Jackson, additional, Moranzoni, Giorgia, additional, Pedersen, Christina B., additional, Liu, Yiwen, additional, Chang, Steven L., additional, Hirsch, Michelle S., additional, LeBoeuf, Nicole R., additional, Mossanen, Matthew, additional, Chea, Vipheaviny, additional, Carulli, Isabel, additional, Olive, Oriol, additional, Mehndiratta, Ambica, additional, Greenslade, Haley, additional, Oliveira, Giacomo, additional, Iorgulescu, J. Bryan, additional, Signoretti, Sabina, additional, Aster, Jon C., additional, Elagina, Liudmila, additional, Leshchiner, Ignaty, additional, Getz, Gad, additional, Harden, Maegan, additional, Gabriel, Stacey, additional, Olsen, Lars R., additional, Neuberg, Donna S., additional, Fritsch, Edward F., additional, Hacohen, Nir, additional, Livak, Kenneth J., additional, Carr, Steven, additional, Ott, Patrick A., additional, Wu, Catherine J., additional, and Choueiri, Toni K., additional
Published: 2023
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36. Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, primary, Lin, Yi, primary, Qu, Conghui, primary, Evangelou, Marina, primary, Ren, Yu, primary, Morrison, John, primary, Albanes, Demetrius, primary, Arndt, Volker, primary, Barry, Elizabeth L., primary, Baurley, James W., primary, Berndt, Sonja I., primary, Bien, Stephanie A., primary, Bishop, D. Timothy, primary, Bouras, Emmanouil, primary, Brenner, Hermann, primary, Buchanan, Daniel D., primary, Budiarto, Arif, primary, Carreras-Torres, Robert, primary, Casey, Graham, primary, Cenggoro, Tjeng Wawan, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Chen, Xuechen, primary, Conti, David V., primary, Devall, Matthew, primary, Diez-Obrero, Virginia, primary, Dimou, Niki, primary, Drew, David, primary, Figueiredo, Jane C., primary, Gallinger, Steven, primary, Giles, Graham G., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hampel, Heather, primary, Harlid, Sophia, primary, Hidaka, Akihisa, primary, Harrison, Tabitha A., primary, Hoffmeister, Michael, primary, Huyghe, Jeroen R., primary, Jenkins, Mark A., primary, Jordahl, Kristina, primary, Joshi, Amit D., primary, Kawaguchi, Eric S., primary, Keku, Temitope O., primary, Kundaje, Anshul, primary, Larsson, Susanna C., primary, Marchand, Loic Le, primary, Lewinger, Juan Pablo, primary, Li, Li, primary, Lynch, Brigid M., primary, Mahesworo, Bharuno, primary, Mandic, Marko, primary, Obón-Santacana, Mireia, primary, Moreno, Victor, primary, Murphy, Neil, primary, Nan, Hongmei, primary, Nassir, Rami, primary, Newcomb, Polly A., primary, Ogino, Shuji, primary, Ose, Jennifer, primary, Pai, Rish K., primary, Palmer, Julie R., primary, Papadimitriou, Nikos, primary, Pardamean, Bens, primary, Peoples, Anita R., primary, Platz, Elizabeth A., primary, Potter, John D., primary, Prentice, Ross L., primary, Rennert, Gad, primary, Ruiz-Narvaez, Edward, primary, Sakoda, Lori C., primary, Scacheri, Peter C., primary, Schmit, Stephanie L., primary, Schoen, Robert E., primary, Shcherbina, Anna, primary, Slattery, Martha L., primary, Stern, Mariana C., primary, Su, Yu-Ru, primary, Tangen, Catherine M., primary, Thibodeau, Stephen N., primary, Thomas, Duncan C., primary, Tian, Yu, primary, Ulrich, Cornelia M., primary, van Duijnhoven, Franzel JB, primary, Van Guelpen, Bethany, primary, Visvanathan, Kala, primary, Vodicka, Pavel, primary, Wang, Jun, primary, White, Emily, primary, Wolk, Alicja, primary, Woods, Michael O., primary, Wu, Anna H., primary, Zemlianskaia, Natalia, primary, Hsu, Li, primary, Gauderman, W. James, primary, Peters, Ulrike, primary, Tsilidis, Konstantinos K., primary, and Campbell, Peter T., primary
Published: 2023
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37. Supplementary Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, primary, Lin, Yi, primary, Qu, Conghui, primary, Evangelou, Marina, primary, Ren, Yu, primary, Morrison, John, primary, Albanes, Demetrius, primary, Arndt, Volker, primary, Barry, Elizabeth L., primary, Baurley, James W., primary, Berndt, Sonja I., primary, Bien, Stephanie A., primary, Bishop, D. Timothy, primary, Bouras, Emmanouil, primary, Brenner, Hermann, primary, Buchanan, Daniel D., primary, Budiarto, Arif, primary, Carreras-Torres, Robert, primary, Casey, Graham, primary, Cenggoro, Tjeng Wawan, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Chen, Xuechen, primary, Conti, David V., primary, Devall, Matthew, primary, Diez-Obrero, Virginia, primary, Dimou, Niki, primary, Drew, David, primary, Figueiredo, Jane C., primary, Gallinger, Steven, primary, Giles, Graham G., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hampel, Heather, primary, Harlid, Sophia, primary, Hidaka, Akihisa, primary, Harrison, Tabitha A., primary, Hoffmeister, Michael, primary, Huyghe, Jeroen R., primary, Jenkins, Mark A., primary, Jordahl, Kristina, primary, Joshi, Amit D., primary, Kawaguchi, Eric S., primary, Keku, Temitope O., primary, Kundaje, Anshul, primary, Larsson, Susanna C., primary, Marchand, Loic Le, primary, Lewinger, Juan Pablo, primary, Li, Li, primary, Lynch, Brigid M., primary, Mahesworo, Bharuno, primary, Mandic, Marko, primary, Obón-Santacana, Mireia, primary, Moreno, Victor, primary, Murphy, Neil, primary, Nan, Hongmei, primary, Nassir, Rami, primary, Newcomb, Polly A., primary, Ogino, Shuji, primary, Ose, Jennifer, primary, Pai, Rish K., primary, Palmer, Julie R., primary, Papadimitriou, Nikos, primary, Pardamean, Bens, primary, Peoples, Anita R., primary, Platz, Elizabeth A., primary, Potter, John D., primary, Prentice, Ross L., primary, Rennert, Gad, primary, Ruiz-Narvaez, Edward, primary, Sakoda, Lori C., primary, Scacheri, Peter C., primary, Schmit, Stephanie L., primary, Schoen, Robert E., primary, Shcherbina, Anna, primary, Slattery, Martha L., primary, Stern, Mariana C., primary, Su, Yu-Ru, primary, Tangen, Catherine M., primary, Thibodeau, Stephen N., primary, Thomas, Duncan C., primary, Tian, Yu, primary, Ulrich, Cornelia M., primary, van Duijnhoven, Franzel JB, primary, Van Guelpen, Bethany, primary, Visvanathan, Kala, primary, Vodicka, Pavel, primary, Wang, Jun, primary, White, Emily, primary, Wolk, Alicja, primary, Woods, Michael O., primary, Wu, Anna H., primary, Zemlianskaia, Natalia, primary, Hsu, Li, primary, Gauderman, W. James, primary, Peters, Ulrike, primary, Tsilidis, Konstantinos K., primary, and Campbell, Peter T., primary
Published: 2023
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38. Table 2 from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, primary, Lin, Yi, primary, Qu, Conghui, primary, Evangelou, Marina, primary, Ren, Yu, primary, Morrison, John, primary, Albanes, Demetrius, primary, Arndt, Volker, primary, Barry, Elizabeth L., primary, Baurley, James W., primary, Berndt, Sonja I., primary, Bien, Stephanie A., primary, Bishop, D. Timothy, primary, Bouras, Emmanouil, primary, Brenner, Hermann, primary, Buchanan, Daniel D., primary, Budiarto, Arif, primary, Carreras-Torres, Robert, primary, Casey, Graham, primary, Cenggoro, Tjeng Wawan, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Chen, Xuechen, primary, Conti, David V., primary, Devall, Matthew, primary, Diez-Obrero, Virginia, primary, Dimou, Niki, primary, Drew, David, primary, Figueiredo, Jane C., primary, Gallinger, Steven, primary, Giles, Graham G., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hampel, Heather, primary, Harlid, Sophia, primary, Hidaka, Akihisa, primary, Harrison, Tabitha A., primary, Hoffmeister, Michael, primary, Huyghe, Jeroen R., primary, Jenkins, Mark A., primary, Jordahl, Kristina, primary, Joshi, Amit D., primary, Kawaguchi, Eric S., primary, Keku, Temitope O., primary, Kundaje, Anshul, primary, Larsson, Susanna C., primary, Marchand, Loic Le, primary, Lewinger, Juan Pablo, primary, Li, Li, primary, Lynch, Brigid M., primary, Mahesworo, Bharuno, primary, Mandic, Marko, primary, Obón-Santacana, Mireia, primary, Moreno, Victor, primary, Murphy, Neil, primary, Nan, Hongmei, primary, Nassir, Rami, primary, Newcomb, Polly A., primary, Ogino, Shuji, primary, Ose, Jennifer, primary, Pai, Rish K., primary, Palmer, Julie R., primary, Papadimitriou, Nikos, primary, Pardamean, Bens, primary, Peoples, Anita R., primary, Platz, Elizabeth A., primary, Potter, John D., primary, Prentice, Ross L., primary, Rennert, Gad, primary, Ruiz-Narvaez, Edward, primary, Sakoda, Lori C., primary, Scacheri, Peter C., primary, Schmit, Stephanie L., primary, Schoen, Robert E., primary, Shcherbina, Anna, primary, Slattery, Martha L., primary, Stern, Mariana C., primary, Su, Yu-Ru, primary, Tangen, Catherine M., primary, Thibodeau, Stephen N., primary, Thomas, Duncan C., primary, Tian, Yu, primary, Ulrich, Cornelia M., primary, van Duijnhoven, Franzel JB, primary, Van Guelpen, Bethany, primary, Visvanathan, Kala, primary, Vodicka, Pavel, primary, Wang, Jun, primary, White, Emily, primary, Wolk, Alicja, primary, Woods, Michael O., primary, Wu, Anna H., primary, Zemlianskaia, Natalia, primary, Hsu, Li, primary, Gauderman, W. James, primary, Peters, Ulrike, primary, Tsilidis, Konstantinos K., primary, and Campbell, Peter T., primary
Published: 2023
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39. Table 1 from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, primary, Lin, Yi, primary, Qu, Conghui, primary, Evangelou, Marina, primary, Ren, Yu, primary, Morrison, John, primary, Albanes, Demetrius, primary, Arndt, Volker, primary, Barry, Elizabeth L., primary, Baurley, James W., primary, Berndt, Sonja I., primary, Bien, Stephanie A., primary, Bishop, D. Timothy, primary, Bouras, Emmanouil, primary, Brenner, Hermann, primary, Buchanan, Daniel D., primary, Budiarto, Arif, primary, Carreras-Torres, Robert, primary, Casey, Graham, primary, Cenggoro, Tjeng Wawan, primary, Chan, Andrew T., primary, Chang-Claude, Jenny, primary, Chen, Xuechen, primary, Conti, David V., primary, Devall, Matthew, primary, Diez-Obrero, Virginia, primary, Dimou, Niki, primary, Drew, David, primary, Figueiredo, Jane C., primary, Gallinger, Steven, primary, Giles, Graham G., primary, Gruber, Stephen B., primary, Gsur, Andrea, primary, Gunter, Marc J., primary, Hampel, Heather, primary, Harlid, Sophia, primary, Hidaka, Akihisa, primary, Harrison, Tabitha A., primary, Hoffmeister, Michael, primary, Huyghe, Jeroen R., primary, Jenkins, Mark A., primary, Jordahl, Kristina, primary, Joshi, Amit D., primary, Kawaguchi, Eric S., primary, Keku, Temitope O., primary, Kundaje, Anshul, primary, Larsson, Susanna C., primary, Marchand, Loic Le, primary, Lewinger, Juan Pablo, primary, Li, Li, primary, Lynch, Brigid M., primary, Mahesworo, Bharuno, primary, Mandic, Marko, primary, Obón-Santacana, Mireia, primary, Moreno, Victor, primary, Murphy, Neil, primary, Nan, Hongmei, primary, Nassir, Rami, primary, Newcomb, Polly A., primary, Ogino, Shuji, primary, Ose, Jennifer, primary, Pai, Rish K., primary, Palmer, Julie R., primary, Papadimitriou, Nikos, primary, Pardamean, Bens, primary, Peoples, Anita R., primary, Platz, Elizabeth A., primary, Potter, John D., primary, Prentice, Ross L., primary, Rennert, Gad, primary, Ruiz-Narvaez, Edward, primary, Sakoda, Lori C., primary, Scacheri, Peter C., primary, Schmit, Stephanie L., primary, Schoen, Robert E., primary, Shcherbina, Anna, primary, Slattery, Martha L., primary, Stern, Mariana C., primary, Su, Yu-Ru, primary, Tangen, Catherine M., primary, Thibodeau, Stephen N., primary, Thomas, Duncan C., primary, Tian, Yu, primary, Ulrich, Cornelia M., primary, van Duijnhoven, Franzel JB, primary, Van Guelpen, Bethany, primary, Visvanathan, Kala, primary, Vodicka, Pavel, primary, Wang, Jun, primary, White, Emily, primary, Wolk, Alicja, primary, Woods, Michael O., primary, Wu, Anna H., primary, Zemlianskaia, Natalia, primary, Hsu, Li, primary, Gauderman, W. James, primary, Peters, Ulrike, primary, Tsilidis, Konstantinos K., primary, and Campbell, Peter T., primary
Published: 2023
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40. In VivoModeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities

Author: Elisa ten Hacken, Tomasz Sewastianik, Shanye Yin, Gabriela Brunsting Hoffmann, Michaela Gruber, Kendell Clement, Livius Penter, Robert A. Redd, Neil Ruthen, Sébastien Hergalant, Alanna Sholokhova, Geoffrey Fell, Erin M. Parry, Julien Broséus, Romain Guieze, Fabienne Lucas, María Hernández-Sánchez, Kaitlyn Baranowski, Jackson Southard, Heather Joyal, Leah Billington, Fara Faye D. Regis, Elizabeth Witten, Mohamed Uduman, Binyamin A. Knisbacher, Shuqiang Li, Haoxiang Lyu, Tiziana Vaisitti, Silvia Deaglio, Giorgio Inghirami, Pierre Feugier, Stephan Stilgenbauer, Eugen Tausch, Matthew S. Davids, Gad Getz, Kenneth J. Livak, Ivana Bozic, Donna S. Neuberg, Ruben D. Carrasco, and Catherine J. Wu
Subjects: General Medicine
Abstract: Transformation to aggressive disease histologies generates formidable clinical challenges across cancers, but biological insights remain few. We modeled the genetic heterogeneity of chronic lymphocytic leukemia (CLL) through multiplexed in vivo CRISPR-Cas9 B-cell editing of recurrent CLL loss-of-function drivers in mice and recapitulated the process of transformation from indolent CLL into large cell lymphoma [i.e., Richter syndrome (RS)]. Evolutionary trajectories of 64 mice carrying diverse combinatorial gene assortments revealed coselection of mutations in Trp53, Mga, and Chd2 and the dual impact of clonal Mga/Chd2 mutations on E2F/MYC and interferon signaling dysregulation. Comparative human and murine RS analyses demonstrated tonic PI3K signaling as a key feature of transformed disease, with constitutive activation of the AKT and S6 kinases, downmodulation of the PTEN phosphatase, and convergent activation of MYC/PI3K transcriptional programs underlying enhanced sensitivity to MYC/mTOR/PI3K inhibition. This robust experimental system presents a unique framework to study lymphoid biology and therapy.Significance:Mouse models reflective of the genetic complexity and heterogeneity of human tumors remain few, including those able to recapitulate transformation to aggressive disease histologies. Herein, we model CLL transformation into RS through multiplexed in vivo gene editing, providing key insight into the pathophysiology and therapeutic vulnerabilities of transformed disease.This article is highlighted in the In This Issue feature, p. 101
Published: 2022
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41. Clinical Efficacy and Whole-Exome Sequencing of Liquid Biopsies in a Phase IB/II Study of Bazedoxifene and Palbociclib in Advanced Hormone Receptor–Positive Breast Cancer

Author: Junko Tsuji, Tianyu Li, Albert Grinshpun, Tim Coorens, Douglas Russo, Leilani Anderson, Rebecca Rees, Agostina Nardone, Candace Patterson, Niall J. Lennon, Carrie Cibulskis, Ignaty Leshchiner, Nabihah Tayob, Sara M. Tolaney, Nadine Tung, Donald P. McDonnell, Ian E. Krop, Eric P. Winer, Chip Stewart, Gad Getz, and Rinath Jeselsohn
Subjects: Cancer Research, Treatment Outcome, Receptors, Estrogen, Oncology, Receptor, ErbB-2, Antineoplastic Combined Chemotherapy Protocols, Exome Sequencing, Liquid Biopsy, Humans, Female, Breast Neoplasms, Article
Abstract: Purpose: Sensitivity to endocrine therapy (ET) is critical for the clinical benefit from the combination of palbociclib plus ET in hormone receptor–positive/HER2-negative (HR+/HER2−) advanced breast cancer. Bazedoxifene is a third-generation selective estrogen receptor (ER) modulator and selective ER degrader with activity in preclinical models of endocrine-resistant breast cancer, including models harboring ESR1 mutations. Clinical trials in healthy women showed that bazedoxifene is well tolerated. Patients and Methods: We conducted a phase Ib/II study of bazedoxifene plus palbociclib in patients with HR+/HER2− advanced breast cancer who progressed on prior ET (N = 36; NCT02448771). Results: The study met its primary endpoint, with a clinical benefit rate of 33.3%, and the safety profile was consistent with what has previously been seen with palbociclib monotherapy. The median progression-free survival (PFS) was 3.6 months [95% confidence interval (CI), 2.0–7.2]. An activating PIK3CA mutation at baseline was associated with a shorter PFS (HR = 4.4; 95% CI, 1.5–13; P = 0.0026), but activating ESR1 mutations did not impact the PFS. Longitudinal plasma circulating tumor DNA whole-exome sequencing (WES; N = 68 plasma samples) provided an overview of the tumor heterogeneity and the subclonal genetic evolution, and identified actionable mutations acquired during treatment. Conclusions: The combination of palbociclib and bazedoxifene has clinical efficacy and an acceptable safety profile in a heavily pretreated patient population with advanced HR+/HER2− breast cancer. These results merit continued investigation of bazedoxifene in breast cancer.
Published: 2022
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42. Trial protocol 1 from Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency

Author: Das, Anirban, primary, Tabori, Uri, primary, Sambira Nahum, Lauren C., primary, Collins, Natalie B., primary, Deyell, Rebecca, primary, Dvir, Rina, primary, Faure-Conter, Cecile, primary, Hassall, Timothy E., primary, Minturn, Jane E., primary, Edwards, Melissa, primary, Brookes, Elissa, primary, Bianchi, Vanessa, primary, Levine, Adrian, primary, Stone, Simone C., primary, Sudhaman, Sumedha, primary, Sanchez Ramirez, Santiago, primary, Ercan, Ayse B., primary, Stengs, Lucie, primary, Chung, Jill, primary, Negm, Logine, primary, Getz, Gad, primary, Maruvka, Yosef E., primary, Ertl-Wagner, Birgit, primary, Ohashi, Pamela S., primary, Pugh, Trevor, primary, Hawkins, Cynthia, primary, Bouffet, Eric, primary, and Morgenstern, Daniel A., primary
Published: 2023
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43. Supplementary Table S1 from Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency

Author: Das, Anirban, primary, Tabori, Uri, primary, Sambira Nahum, Lauren C., primary, Collins, Natalie B., primary, Deyell, Rebecca, primary, Dvir, Rina, primary, Faure-Conter, Cecile, primary, Hassall, Timothy E., primary, Minturn, Jane E., primary, Edwards, Melissa, primary, Brookes, Elissa, primary, Bianchi, Vanessa, primary, Levine, Adrian, primary, Stone, Simone C., primary, Sudhaman, Sumedha, primary, Sanchez Ramirez, Santiago, primary, Ercan, Ayse B., primary, Stengs, Lucie, primary, Chung, Jill, primary, Negm, Logine, primary, Getz, Gad, primary, Maruvka, Yosef E., primary, Ertl-Wagner, Birgit, primary, Ohashi, Pamela S., primary, Pugh, Trevor, primary, Hawkins, Cynthia, primary, Bouffet, Eric, primary, and Morgenstern, Daniel A., primary
Published: 2023
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44. Suppl Figure S1 from Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency

Author: Das, Anirban, primary, Tabori, Uri, primary, Sambira Nahum, Lauren C., primary, Collins, Natalie B., primary, Deyell, Rebecca, primary, Dvir, Rina, primary, Faure-Conter, Cecile, primary, Hassall, Timothy E., primary, Minturn, Jane E., primary, Edwards, Melissa, primary, Brookes, Elissa, primary, Bianchi, Vanessa, primary, Levine, Adrian, primary, Stone, Simone C., primary, Sudhaman, Sumedha, primary, Sanchez Ramirez, Santiago, primary, Ercan, Ayse B., primary, Stengs, Lucie, primary, Chung, Jill, primary, Negm, Logine, primary, Getz, Gad, primary, Maruvka, Yosef E., primary, Ertl-Wagner, Birgit, primary, Ohashi, Pamela S., primary, Pugh, Trevor, primary, Hawkins, Cynthia, primary, Bouffet, Eric, primary, and Morgenstern, Daniel A., primary
Published: 2023
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45. Data from Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency

Author: Das, Anirban, primary, Tabori, Uri, primary, Sambira Nahum, Lauren C., primary, Collins, Natalie B., primary, Deyell, Rebecca, primary, Dvir, Rina, primary, Faure-Conter, Cecile, primary, Hassall, Timothy E., primary, Minturn, Jane E., primary, Edwards, Melissa, primary, Brookes, Elissa, primary, Bianchi, Vanessa, primary, Levine, Adrian, primary, Stone, Simone C., primary, Sudhaman, Sumedha, primary, Sanchez Ramirez, Santiago, primary, Ercan, Ayse B., primary, Stengs, Lucie, primary, Chung, Jill, primary, Negm, Logine, primary, Getz, Gad, primary, Maruvka, Yosef E., primary, Ertl-Wagner, Birgit, primary, Ohashi, Pamela S., primary, Pugh, Trevor, primary, Hawkins, Cynthia, primary, Bouffet, Eric, primary, and Morgenstern, Daniel A., primary
Published: 2023
Full Text: View/download PDF

46. A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Author: Aglago, Elom K., primary, Kim, Andre, additional, Lin, Yi, additional, Qu, Conghui, additional, Evangelou, Marina, additional, Ren, Yu, additional, Morrison, John, additional, Albanes, Demetrius, additional, Arndt, Volker, additional, Barry, Elizabeth L., additional, Baurley, James W., additional, Berndt, Sonja I., additional, Bien, Stephanie A., additional, Bishop, D. Timothy, additional, Bouras, Emmanouil, additional, Brenner, Hermann, additional, Buchanan, Daniel D., additional, Budiarto, Arif, additional, Carreras-Torres, Robert, additional, Casey, Graham, additional, Cenggoro, Tjeng Wawan, additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chen, Xuechen, additional, Conti, David V., additional, Devall, Matthew, additional, Diez-Obrero, Virginia, additional, Dimou, Niki, additional, Drew, David, additional, Figueiredo, Jane C., additional, Gallinger, Steven, additional, Giles, Graham G., additional, Gruber, Stephen B., additional, Gsur, Andrea, additional, Gunter, Marc J., additional, Hampel, Heather, additional, Harlid, Sophia, additional, Hidaka, Akihisa, additional, Harrison, Tabitha A., additional, Hoffmeister, Michael, additional, Huyghe, Jeroen R., additional, Jenkins, Mark A., additional, Jordahl, Kristina, additional, Joshi, Amit D., additional, Kawaguchi, Eric S., additional, Keku, Temitope O., additional, Kundaje, Anshul, additional, Larsson, Susanna C., additional, Marchand, Loic Le, additional, Lewinger, Juan Pablo, additional, Li, Li, additional, Lynch, Brigid M., additional, Mahesworo, Bharuno, additional, Mandic, Marko, additional, Obón-Santacana, Mireia, additional, Moreno, Victor, additional, Murphy, Neil, additional, Nan, Hongmei, additional, Nassir, Rami, additional, Newcomb, Polly A., additional, Ogino, Shuji, additional, Ose, Jennifer, additional, Pai, Rish K., additional, Palmer, Julie R., additional, Papadimitriou, Nikos, additional, Pardamean, Bens, additional, Peoples, Anita R., additional, Platz, Elizabeth A., additional, Potter, John D., additional, Prentice, Ross L., additional, Rennert, Gad, additional, Ruiz-Narvaez, Edward, additional, Sakoda, Lori C., additional, Scacheri, Peter C., additional, Schmit, Stephanie L., additional, Schoen, Robert E., additional, Shcherbina, Anna, additional, Slattery, Martha L., additional, Stern, Mariana C., additional, Su, Yu-Ru, additional, Tangen, Catherine M., additional, Thibodeau, Stephen N., additional, Thomas, Duncan C., additional, Tian, Yu, additional, Ulrich, Cornelia M., additional, van Duijnhoven, Franzel JB, additional, Van Guelpen, Bethany, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Wang, Jun, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O., additional, Wu, Anna H., additional, Zemlianskaia, Natalia, additional, Hsu, Li, additional, Gauderman, W. James, additional, Peters, Ulrike, additional, Tsilidis, Konstantinos K., additional, and Campbell, Peter T., additional
Published: 2023
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47. Table S5 from Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors

Author: Toker, Joseph, primary, Iorgulescu, J. Bryan, primary, Ling, Alexander L., primary, Villa, Genaro R., primary, Gadet, Josephina A.M.A., primary, Parida, Laxmi, primary, Getz, Gad, primary, Wu, Catherine J., primary, Reardon, David A., primary, Chiocca, E. Antonio, primary, and Mineo, Marco, primary
Published: 2023
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48. Supplementary Fig. 2 from Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors

Author: Toker, Joseph, primary, Iorgulescu, J. Bryan, primary, Ling, Alexander L., primary, Villa, Genaro R., primary, Gadet, Josephina A.M.A., primary, Parida, Laxmi, primary, Getz, Gad, primary, Wu, Catherine J., primary, Reardon, David A., primary, Chiocca, E. Antonio, primary, and Mineo, Marco, primary
Published: 2023
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49. Supplementary Fig. 1 from Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors

Author: Toker, Joseph, primary, Iorgulescu, J. Bryan, primary, Ling, Alexander L., primary, Villa, Genaro R., primary, Gadet, Josephina A.M.A., primary, Parida, Laxmi, primary, Getz, Gad, primary, Wu, Catherine J., primary, Reardon, David A., primary, Chiocca, E. Antonio, primary, and Mineo, Marco, primary
Published: 2023
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50. Supplementary Fig. 4 from Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors

Author: Toker, Joseph, primary, Iorgulescu, J. Bryan, primary, Ling, Alexander L., primary, Villa, Genaro R., primary, Gadet, Josephina A.M.A., primary, Parida, Laxmi, primary, Getz, Gad, primary, Wu, Catherine J., primary, Reardon, David A., primary, Chiocca, E. Antonio, primary, and Mineo, Marco, primary
Published: 2023
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