Search

Your search keyword '"Chaïma Benaksas"' showing total 20 results
Start Over Author "Chaïma Benaksas" Publisher american association for cancer research (aacr)
20 results on '"Chaïma Benaksas"'

1. Figure S9 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Effect of MTHFR impairment on response to OTX015.

Published
2023

2. Figure S7 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

MTHFR suppression does not alter AML cell response to venetoclax.

Published
2023

3. Table S6 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

List of sgRNA Guides Used in the CRISPR Screen.

Published
2023

4. Table S7 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

List of top epigenetic rescuers of or sensitizers to JQ1.

Published
2023

5. Table S4 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Characteristics of CBF AML patient samples used in this study.

Published
2023

6. Figure S6 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

MTAP suppression modulates response to BET inhibitors.

Published
2023

7. Figure S12 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Transcriptional and epigenetic changes induced by folate starvation in AML cells.

Published
2023

8. Figure S13 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Spi1 knockdown alleviates the resistance to JQ1 mediated by folic acid withdrawal.

Published
2023

9. Figure S1 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

CDK7 inhibitor, THZ-1, decreases MYC expression in AML cells.

Published
2023

10. Data from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Deciphering the impact of metabolic intervention on response to anticancer therapy may elucidate a path toward improved clinical responses. Here, we identify amino acid–related pathways connected to the folate cycle whose activation predicts sensitivity to MYC-targeting therapies in acute myeloid leukemia (AML). We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme MTHFR, which exhibits reduced-function polymorphisms in about 10% of Caucasians, induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML. Furthermore, this effect is abrogated by supplementation with the MTHFR enzymatic product CH3-THF. Mechanistically, folate cycle disturbance reduces H3K27/K9 histone methylation and activates a SPI1 transcriptional program counteracting the effect of BET inhibition. Our data provide a rationale for screening MTHFR polymorphisms and folate cycle status to nominate patients most likely to benefit from MYC-targeting therapies.Significance:Although MYC-targeting therapies represent a promising strategy for cancer treatment, evidence of predictors of sensitivity to these agents is limited. We pinpoint that folate cycle disturbance and frequent polymorphisms associated with reduced MTHFR activity promote resistance to BET inhibitors. CH3-THF supplementation thus represents a low-risk intervention to enhance their effects.See related commentary by Marando and Huntly, p. 1791.This article is highlighted in the In This Issue feature, p. 1775

Published
2023

11. Figure S11 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

CRISPR screen hit validation.

Published
2023

12. Figure S3 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Folic acid withdrawal attenuates leukemic blast response to JQ1.

Published
2023

13. Table S3 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Characteristics of MLL-rearranged AML patient samples used in this study.

Published
2023

14. Figure S10 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Metabolic perturbations induced by folate starvation in AML cells.

Published
2023

15. Figure S5 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Methotrexate and OTX015 are antagonistic in various AML cell lines.

Published
2023

16. Table S1 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

List of metabolic gene sets queried using ssGSEA on the two cohorts of patients with AML (TCGA-LAML and GSE14468).

Published
2023

17. Supplementary Data from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Supplementary Material and Methods

Published
2023

18. Table S5 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

List of Top Differentially Regulated Metabolites.

Published
2023

19. Table S2 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Supplementary Table S2

Published
2023

20. Figure S2 from The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author

Alexandre Puissant, Raphael Itzykson, Kris C. Wood, Camille Lobry, Kimberly Stegmaier, Hava M. Golan, Lina Benajiba, Nina Fenouille, Claude Preudhomme, Hervé Dombret, Thomas Cluzeau, Giovanni Roti, Jean-Baptiste Micol, Marie-Hélène Schlageter, Jun Qi, Yana Pikman, Alain Pruvost, Jean-François Benoist, Gabriela Alexe, Iléana Antony-Debré, Justine Pasanisi, Gael Fortin, Christopher F. Bassil, Justine C. Rutter, Kevin H. Lin, Bryann Pardieu, Antoine Forget, Reinaldo Dal Bello, Chaïma Benaksas, Gaetano Sodaro, Camille Vaganay, Frank Ling, and Angela Su

Abstract

Folic acid withdrawal does not significantly affect mouse hematocrit, white blood count, and weight.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results