Search

Your search keyword '"Buczkowicz, Pawel"' showing total 18 results
Start Over Author "Buczkowicz, Pawel" Publisher american association for cancer research (aacr)
18 results on '"Buczkowicz, Pawel"'

1. Supplementary Table 1 - Cell line information from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Author

Chornenkyy, Yevgen, primary, Agnihotri, Sameer, primary, Yu, Man, primary, Buczkowicz, Pawel, primary, Rakopoulos, Patricia, primary, Golbourn, Brian, primary, Garzia, Livia, primary, Siddaway, Robert, primary, Leung, Stephie, primary, Rutka, James T., primary, Taylor, Michael D., primary, Dirks, Peter B., primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

2. Supplementary Figure 1 - PARP1 protein is expressed in pHGA and DIPG patient samples from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Author

Chornenkyy, Yevgen, primary, Agnihotri, Sameer, primary, Yu, Man, primary, Buczkowicz, Pawel, primary, Rakopoulos, Patricia, primary, Golbourn, Brian, primary, Garzia, Livia, primary, Siddaway, Robert, primary, Leung, Stephie, primary, Rutka, James T., primary, Taylor, Michael D., primary, Dirks, Peter B., primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

3. Supplementary Figure 4 - Niraparib induces growth arrest in SJG2 and SF188 cells. from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Author

Chornenkyy, Yevgen, primary, Agnihotri, Sameer, primary, Yu, Man, primary, Buczkowicz, Pawel, primary, Rakopoulos, Patricia, primary, Golbourn, Brian, primary, Garzia, Livia, primary, Siddaway, Robert, primary, Leung, Stephie, primary, Rutka, James T., primary, Taylor, Michael D., primary, Dirks, Peter B., primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

4. Supplemental Figure Legends from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents

Author

Agnihotri, Sameer, primary, Burrell, Kelly, primary, Buczkowicz, Pawel, primary, Remke, Marc, primary, Golbourn, Brian, primary, Chornenkyy, Yevgen, primary, Gajadhar, Aaron, primary, Fernandez, Nestor A., primary, Clarke, Ian D., primary, Barszczyk, Mark S., primary, Pajovic, Sanja, primary, Ternamian, Christian, primary, Head, Renee, primary, Sabha, Nesrin, primary, Sobol, Robert W., primary, Taylor, Michael D., primary, Rutka, James T., primary, Jones, Chris, primary, Dirks, Peter B., primary, Zadeh, Gelareh, primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

5. Data from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents

Author

Agnihotri, Sameer, primary, Burrell, Kelly, primary, Buczkowicz, Pawel, primary, Remke, Marc, primary, Golbourn, Brian, primary, Chornenkyy, Yevgen, primary, Gajadhar, Aaron, primary, Fernandez, Nestor A., primary, Clarke, Ian D., primary, Barszczyk, Mark S., primary, Pajovic, Sanja, primary, Ternamian, Christian, primary, Head, Renee, primary, Sabha, Nesrin, primary, Sobol, Robert W., primary, Taylor, Michael D., primary, Rutka, James T., primary, Jones, Chris, primary, Dirks, Peter B., primary, Zadeh, Gelareh, primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

6. Supplemental Figures 1 - 9 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents

Author

Agnihotri, Sameer, primary, Burrell, Kelly, primary, Buczkowicz, Pawel, primary, Remke, Marc, primary, Golbourn, Brian, primary, Chornenkyy, Yevgen, primary, Gajadhar, Aaron, primary, Fernandez, Nestor A., primary, Clarke, Ian D., primary, Barszczyk, Mark S., primary, Pajovic, Sanja, primary, Ternamian, Christian, primary, Head, Renee, primary, Sabha, Nesrin, primary, Sobol, Robert W., primary, Taylor, Michael D., primary, Rutka, James T., primary, Jones, Chris, primary, Dirks, Peter B., primary, Zadeh, Gelareh, primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

7. Supplementary Figure 3 - Niraparib treatment increases DNA damage and decreases proliferation. from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Author

Chornenkyy, Yevgen, primary, Agnihotri, Sameer, primary, Yu, Man, primary, Buczkowicz, Pawel, primary, Rakopoulos, Patricia, primary, Golbourn, Brian, primary, Garzia, Livia, primary, Siddaway, Robert, primary, Leung, Stephie, primary, Rutka, James T., primary, Taylor, Michael D., primary, Dirks, Peter B., primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

8. Supplemental Methods from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents

Author

Agnihotri, Sameer, primary, Burrell, Kelly, primary, Buczkowicz, Pawel, primary, Remke, Marc, primary, Golbourn, Brian, primary, Chornenkyy, Yevgen, primary, Gajadhar, Aaron, primary, Fernandez, Nestor A., primary, Clarke, Ian D., primary, Barszczyk, Mark S., primary, Pajovic, Sanja, primary, Ternamian, Christian, primary, Head, Renee, primary, Sabha, Nesrin, primary, Sobol, Robert W., primary, Taylor, Michael D., primary, Rutka, James T., primary, Jones, Chris, primary, Dirks, Peter B., primary, Zadeh, Gelareh, primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

9. Supplementary Figure Legends from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Author

Chornenkyy, Yevgen, primary, Agnihotri, Sameer, primary, Yu, Man, primary, Buczkowicz, Pawel, primary, Rakopoulos, Patricia, primary, Golbourn, Brian, primary, Garzia, Livia, primary, Siddaway, Robert, primary, Leung, Stephie, primary, Rutka, James T., primary, Taylor, Michael D., primary, Dirks, Peter B., primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

10. Supplemental Table 1 from ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents

Author

Agnihotri, Sameer, primary, Burrell, Kelly, primary, Buczkowicz, Pawel, primary, Remke, Marc, primary, Golbourn, Brian, primary, Chornenkyy, Yevgen, primary, Gajadhar, Aaron, primary, Fernandez, Nestor A., primary, Clarke, Ian D., primary, Barszczyk, Mark S., primary, Pajovic, Sanja, primary, Ternamian, Christian, primary, Head, Renee, primary, Sabha, Nesrin, primary, Sobol, Robert W., primary, Taylor, Michael D., primary, Rutka, James T., primary, Jones, Chris, primary, Dirks, Peter B., primary, Zadeh, Gelareh, primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

11. Supplementary Figure 2 - Cell viability assay for pediatric brain tumour lines exposed to the indicated concentrations of Veliparib, Olaparib, or Niraparib. from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Author

Chornenkyy, Yevgen, primary, Agnihotri, Sameer, primary, Yu, Man, primary, Buczkowicz, Pawel, primary, Rakopoulos, Patricia, primary, Golbourn, Brian, primary, Garzia, Livia, primary, Siddaway, Robert, primary, Leung, Stephie, primary, Rutka, James T., primary, Taylor, Michael D., primary, Dirks, Peter B., primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

12. Supplementary Figure 5 - Low doses of Niraparib reduce the rate of DNA repair and sensitize cells to ionizing radiation from Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Author

Chornenkyy, Yevgen, primary, Agnihotri, Sameer, primary, Yu, Man, primary, Buczkowicz, Pawel, primary, Rakopoulos, Patricia, primary, Golbourn, Brian, primary, Garzia, Livia, primary, Siddaway, Robert, primary, Leung, Stephie, primary, Rutka, James T., primary, Taylor, Michael D., primary, Dirks, Peter B., primary, and Hawkins, Cynthia, primary

Published
2023
Full Text
View/download PDF

14. Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma

Author

Chornenkyy, Yevgen, primary, Agnihotri, Sameer, additional, Yu, Man, additional, Buczkowicz, Pawel, additional, Rakopoulos, Patricia, additional, Golbourn, Brian, additional, Garzia, Livia, additional, Siddaway, Robert, additional, Leung, Stephie, additional, Rutka, James T., additional, Taylor, Michael D., additional, Dirks, Peter B., additional, and Hawkins, Cynthia, additional

Published
2015
Full Text
View/download PDF

16. ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents

Author

Agnihotri, Sameer, primary, Burrell, Kelly, additional, Buczkowicz, Pawel, additional, Remke, Marc, additional, Golbourn, Brian, additional, Chornenkyy, Yevgen, additional, Gajadhar, Aaron, additional, Fernandez, Nestor A., additional, Clarke, Ian D., additional, Barszczyk, Mark S., additional, Pajovic, Sanja, additional, Ternamian, Christian, additional, Head, Renee, additional, Sabha, Nesrin, additional, Sobol, Robert W., additional, Taylor, Michael D., additional, Rutka, James T., additional, Jones, Chris, additional, Dirks, Peter B., additional, Zadeh, Gelareh, additional, and Hawkins, Cynthia, additional

Published
2014
Full Text
View/download PDF

18. Abstract 2129: Pediatric diffuse intrinsic pontine gliomas are genetically distinct from high and low grade astrocytomas

Author

Cynthia Hawkins, Maryam Zarghooni, Andrew Morrison, Eric Bouffet, Ute Bartels, and Buczkowicz Pawel

Subjects
Cancer Research, Pathology, medicine.medical_specialty, business.industry, Brain tumor, Disease, medicine.disease, Copy Number Analysis Tool, Pons, Prostate cancer, Oncology, medicine, Brainstem glioma, SNP, Brainstem, business
Abstract

Tumors of the central nervous system constitute the most common type of solid pediatric tumors and account for the majority of mortality and morbidity in pediatric oncology. Brainstem glioma (BSG) is a type of brain tumor that arises in the medulla, pons or midbrain and accounts for approximately 10-20% of pediatric brain tumors. Diffuse gliomas of the pontine region, diffuse intrinsic pontine glioma (DIPG) are the most common type of brainstem tumor, accounting for about 58-78% of BSG and the number one cause of brain tumor related death in children with a 1-2 year survival. Despite this very little is understood about the biology of these tumors. To try to address this lack of knowledge we have undertaken genomic analysis of a series of DIPGs and compared their copy number changes to those seen in pediatric supratentorial high grade astrocytomas as well as low grade astrocytomas. Post mortem tumor and matched normal brain samples (n= 9) and surgical samples (n= 4) were collected for a series of DIPG patients. We performed high-resolution genetic analysis using whole-genome single-nucleotide polymorphism (SNP) arrays (Affymetrix 500K and 6.0). Data analysis was conducted using Partek Genome Suite and Copy Number Analysis Tool (Affymetrix). Analysis of copy number alterations returned hits in several cancer related pathways including MAPK, Wnt, prostate cancer and gliomagenesis. DIPG copy number was also compared to that of pediatric high grade (n= 20) and low grade (n= 30) astrocytomas. Unsupervised Pearson's Dissimilarity clustering resulted in 3 distinct groups. One contained 6 DIPGs; the second contained mostly LGA with a few HGA, while the third group contained mostly HGA with the remaining DIPGs clustering with this group. Although there were some similarities, DIPG are genetically distinct from supratentorial high grade and low grade astrocytomas. A better understanding of DIPG biology is needed in order to develop agents targeted more specifically towards this disease particularly given the dismal prognosis and unresponsive nature of these tumors to conventional treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2129.

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results