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Start Over Author "Bontadini, A." Publisher american association for cancer research (aacr)
15 results on '"Bontadini, A."'

1. Figure S3 from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, primary, Parisi, Sarah, primary, Bontadini, Andrea, primary, Dan, Elisa, primary, Motta, Maria Rosa, primary, Rizzi, Simonetta, primary, Trabanelli, Sara, primary, Ocadlikova, Darina, primary, Lecciso, Mariangela, primary, Giudice, Valeria, primary, Fruet, Fiorenza, primary, Urbani, Elena, primary, Papayannidis, Cristina, primary, Martinelli, Giovanni, primary, Bandini, Giuseppe, primary, Bonifazi, Francesca, primary, Lewis, Russell E., primary, Cavo, Michele, primary, Velardi, Andrea, primary, and Lemoli, Roberto M., primary

Published
2023
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2. Data from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, primary, Parisi, Sarah, primary, Bontadini, Andrea, primary, Dan, Elisa, primary, Motta, Maria Rosa, primary, Rizzi, Simonetta, primary, Trabanelli, Sara, primary, Ocadlikova, Darina, primary, Lecciso, Mariangela, primary, Giudice, Valeria, primary, Fruet, Fiorenza, primary, Urbani, Elena, primary, Papayannidis, Cristina, primary, Martinelli, Giovanni, primary, Bandini, Giuseppe, primary, Bonifazi, Francesca, primary, Lewis, Russell E., primary, Cavo, Michele, primary, Velardi, Andrea, primary, and Lemoli, Roberto M., primary

Published
2023
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3. supplemental figure legend from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, primary, Parisi, Sarah, primary, Bontadini, Andrea, primary, Dan, Elisa, primary, Motta, Maria Rosa, primary, Rizzi, Simonetta, primary, Trabanelli, Sara, primary, Ocadlikova, Darina, primary, Lecciso, Mariangela, primary, Giudice, Valeria, primary, Fruet, Fiorenza, primary, Urbani, Elena, primary, Papayannidis, Cristina, primary, Martinelli, Giovanni, primary, Bandini, Giuseppe, primary, Bonifazi, Francesca, primary, Lewis, Russell E., primary, Cavo, Michele, primary, Velardi, Andrea, primary, and Lemoli, Roberto M., primary

Published
2023
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4. Supplementary Tables S1 and S2 from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, primary, Parisi, Sarah, primary, Bontadini, Andrea, primary, Dan, Elisa, primary, Motta, Maria Rosa, primary, Rizzi, Simonetta, primary, Trabanelli, Sara, primary, Ocadlikova, Darina, primary, Lecciso, Mariangela, primary, Giudice, Valeria, primary, Fruet, Fiorenza, primary, Urbani, Elena, primary, Papayannidis, Cristina, primary, Martinelli, Giovanni, primary, Bandini, Giuseppe, primary, Bonifazi, Francesca, primary, Lewis, Russell E., primary, Cavo, Michele, primary, Velardi, Andrea, primary, and Lemoli, Roberto M., primary

Published
2023
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5. Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

Author

Tazzari, Pier Luigi, primary, Tabellini, Giovanna, primary, Ricci, Francesca, primary, Papa, Veronica, primary, Bortul, Roberta, primary, Chiarini, Francesca, primary, Evangelisti, Camilla, primary, Martinelli, Giovanni, primary, Bontadini, Andrea, primary, Cocco, Lucio, primary, McCubrey, James A., primary, and Martelli, Alberto M., primary

Published
2023
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6. Data from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

Author

Tazzari, Pier Luigi, primary, Tabellini, Giovanna, primary, Ricci, Francesca, primary, Papa, Veronica, primary, Bortul, Roberta, primary, Chiarini, Francesca, primary, Evangelisti, Camilla, primary, Martinelli, Giovanni, primary, Bontadini, Andrea, primary, Cocco, Lucio, primary, McCubrey, James A., primary, and Martelli, Alberto M., primary

Published
2023
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7. Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

Author

Tazzari, Pier Luigi, primary, Tabellini, Giovanna, primary, Ricci, Francesca, primary, Papa, Veronica, primary, Bortul, Roberta, primary, Chiarini, Francesca, primary, Evangelisti, Camilla, primary, Martinelli, Giovanni, primary, Bontadini, Andrea, primary, Cocco, Lucio, primary, McCubrey, James A., primary, and Martelli, Alberto M., primary

Published
2023
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8. Figure S1 from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Roberto M. Lemoli, Andrea Velardi, Michele Cavo, Russell E. Lewis, Francesca Bonifazi, Giuseppe Bandini, Giovanni Martinelli, Cristina Papayannidis, Elena Urbani, Fiorenza Fruet, Valeria Giudice, Mariangela Lecciso, Darina Ocadlikova, Sara Trabanelli, Simonetta Rizzi, Maria Rosa Motta, Elisa Dan, Andrea Bontadini, Sarah Parisi, Loredana Ruggeri, and Antonio Curti

Abstract

Figure S1. Hematologic recovery after NK cell infusion in all treated patients.

Published
2023

9. Supplementary Tables S1 and S2 from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Roberto M. Lemoli, Andrea Velardi, Michele Cavo, Russell E. Lewis, Francesca Bonifazi, Giuseppe Bandini, Giovanni Martinelli, Cristina Papayannidis, Elena Urbani, Fiorenza Fruet, Valeria Giudice, Mariangela Lecciso, Darina Ocadlikova, Sara Trabanelli, Simonetta Rizzi, Maria Rosa Motta, Elisa Dan, Andrea Bontadini, Sarah Parisi, Loredana Ruggeri, and Antonio Curti

Abstract

Table S1. Percentage and absolute number of alloreactive NK cells in responders (A) and non-responders (B) Table S2. Description of cell processing results in responders (A) and non-responders (B)

Published
2023

10. Data from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Roberto M. Lemoli, Andrea Velardi, Michele Cavo, Russell E. Lewis, Francesca Bonifazi, Giuseppe Bandini, Giovanni Martinelli, Cristina Papayannidis, Elena Urbani, Fiorenza Fruet, Valeria Giudice, Mariangela Lecciso, Darina Ocadlikova, Sara Trabanelli, Simonetta Rizzi, Maria Rosa Motta, Elisa Dan, Andrea Bontadini, Sarah Parisi, Loredana Ruggeri, and Antonio Curti

Abstract

Purpose: In acute myeloid leukemia (AML), alloreactive natural killer (NK) cells are crucial mediators of immune responses after haploidentical stem cell transplantation. Allogeneic NK cell infusions have been adoptively transferred with promising clinical results. We aimed at determining whether the composition of NK graft in terms of frequency of alloreactive NK cells influence the clinical response in a group of elderly AML patients undergoing NK immunotherapy.Experimental Design: Seventeen AML patients, in first complete remission (CR; median age 64 years, range 53–73) received NK cells from haploidentical KIR-ligand–mismatched donors after fludarabine/cyclophosphamide chemotherapy, followed by IL2. To correlate donor NK cell activity with clinical response, donor NK cells were assessed before and after infusion.Results: Toxicity was moderate, although 1 patient died due to bacterial pneumonia and was censored for clinical follow-up. With a median follow-up of 22.5 months (range, 6–68 months), 9 of 16 evaluable patients (0.56) are alive disease-free, whereas 7 of 16 (0.44) relapsed with a median time to relapse of 9 months (range, 3–51 months). All patients treated with molecular disease achieved molecular CR. A significantly higher number of donor alloreactive NK cell clones was observed in responders over nonresponders. The infusion of higher number of alloreactive NK cells was associated with prolonged disease-free survival (0.81 vs. 0.14, respectively; P = 0.03).Conclusions: Infusion of purified NK cells is feasible in elderly AML patients as post-CR consolidation strategy. The clinical efficacy of adoptively transferred haploidentical NK cells may be improved by infusing high numbers of alloreactive NK cells. Clin Cancer Res; 22(8); 1914–21. ©2016 AACR.See related commentary by Muntasell and López-Botet, p. 1831

Published
2023

11. supplemental figure legend from Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Roberto M. Lemoli, Andrea Velardi, Michele Cavo, Russell E. Lewis, Francesca Bonifazi, Giuseppe Bandini, Giovanni Martinelli, Cristina Papayannidis, Elena Urbani, Fiorenza Fruet, Valeria Giudice, Mariangela Lecciso, Darina Ocadlikova, Sara Trabanelli, Simonetta Rizzi, Maria Rosa Motta, Elisa Dan, Andrea Bontadini, Sarah Parisi, Loredana Ruggeri, and Antonio Curti

Abstract

supplemental figure legend

Published
2023

12. Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

Author

Alberto M. Martelli, James A. McCubrey, Lucio Cocco, Andrea Bontadini, Giovanni Martinelli, Camilla Evangelisti, Francesca Chiarini, Roberta Bortul, Veronica Papa, Francesca Ricci, Giovanna Tabellini, and Pier Luigi Tazzari

Abstract

Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

Published
2023

13. Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

Author

Alberto M. Martelli, James A. McCubrey, Lucio Cocco, Andrea Bontadini, Giovanni Martinelli, Camilla Evangelisti, Francesca Chiarini, Roberta Bortul, Veronica Papa, Francesca Ricci, Giovanna Tabellini, and Pier Luigi Tazzari

Abstract

Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

Published
2023

14. Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients

Author

Curti, Antonio, primary, Ruggeri, Loredana, additional, Parisi, Sarah, additional, Bontadini, Andrea, additional, Dan, Elisa, additional, Motta, Maria Rosa, additional, Rizzi, Simonetta, additional, Trabanelli, Sara, additional, Ocadlikova, Darina, additional, Lecciso, Mariangela, additional, Giudice, Valeria, additional, Fruet, Fiorenza, additional, Urbani, Elena, additional, Papayannidis, Cristina, additional, Martinelli, Giovanni, additional, Bandini, Giuseppe, additional, Bonifazi, Francesca, additional, Lewis, Russell E., additional, Cavo, Michele, additional, Velardi, Andrea, additional, and Lemoli, Roberto M., additional

Published
2016
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15. Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells

Author

Tazzari, Pier Luigi, primary, Tabellini, Giovanna, additional, Ricci, Francesca, additional, Papa, Veronica, additional, Bortul, Roberta, additional, Chiarini, Francesca, additional, Evangelisti, Camilla, additional, Martinelli, Giovanni, additional, Bontadini, Andrea, additional, Cocco, Lucio, additional, McCubrey, James A., additional, and Martelli, Alberto M., additional

Published
2008
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