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Start Over Author "Austin, R. A." Publisher american association for cancer research (aacr)
269 results on '"Austin, R. A."'

1. Supplementary Figure S6 from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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2. Supplementary Data from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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3. Supplementary Materials and Methods from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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4. Supplementary Figure Legends from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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5. Data from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Author

Singh, Samara P., primary, Dosch, Austin R., primary, Mehra, Siddharth, primary, De Castro Silva, Iago, primary, Bianchi, Anna, primary, Garrido, Vanessa T., primary, Zhou, Zhiqun, primary, Adams, Andrew, primary, Amirian, Haleh, primary, Box, Edmond W., primary, Sun, Xiaodian, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2024
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6. Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer

Author

Singh, Samara P., primary, Dosch, Austin R., additional, Mehra, Siddharth, additional, de Castro Silva, Iago, additional, Garrido, Vanessa Tonin, additional, Bianchi, Anna, additional, Amirian, Haleh, additional, Box, Edmond W., additional, Datta, Jashodeep, additional, Nagathihalli, Nagaraj S., additional, and Merchant, Nipun B., additional

Published
2024
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10. Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Author

Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande, Samara Singh, Siddharth Mehra, Vanessa T. Garrido, Xinyu Guo, Luis A. Nivelo, Despina S. Kolonias, Shannon J. Saigh, Eric Wieder, Christine I. Rafie, Austin R. Dosch, Zhiqun Zhou, Oliver Umland, Haleh Amirian, Ifeanyichukwu C. Ogobuiro, Jian Zhang, Yuguang Ban, Carina Shiau, Nagaraj S. Nagathihalli, Elizabeth A. Montgomery, William L. Hwang, Roberta Brambilla, Krishna Komanduri, Alejandro V. Villarino, Eneda Toska, Ben Z. Stanger, Dmitry I. Gabrilovich, Nipun B. Merchant, and Jashodeep Datta

Subjects
Oncology
Abstract

We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded microenvironments, chemoresistance, and poor survival in pancreatic ductal adenocarcinoma (PDAC) patients. By treating KRAS–TP53 cooperativity as a model for high-risk biology, we now identify cell-autonomous Cxcl1 as a key mediator of spatial T-cell restriction via interactions with CXCR2+ neutrophilic myeloid-derived suppressor cells in human PDAC using imaging mass cytometry. Silencing of cell-intrinsic Cxcl1 in LSL-KrasG12D/+;Trp53R172H/+;Pdx-1Cre/+(KPC) cells reprograms the trafficking and functional dynamics of neutrophils to overcome T-cell exclusion and controls tumor growth in a T cell–dependent manner. Mechanistically, neutrophil-derived TNF is a central regulator of this immunologic rewiring, instigating feed-forward Cxcl1 overproduction from tumor cells and cancer-associated fibroblasts (CAF), T-cell dysfunction, and inflammatory CAF polarization via transmembrane TNF–TNFR2 interactions. TNFR2 inhibition disrupts this circuitry and improves sensitivity to chemotherapy in vivo. Our results uncover cancer cell–neutrophil cross-talk in which context-dependent TNF signaling amplifies stromal inflammation and immune tolerance to promote therapeutic resistance in PDAC. Significance: By decoding connections between high-risk tumor genotypes, cell-autonomous inflammatory programs, and myeloid-enriched/T cell–excluded contexts, we identify a novel role for neutrophil-derived TNF in sustaining immunosuppression and stromal inflammation in pancreatic tumor microenvironments. This work offers a conceptual framework by which targeting context-dependent TNF signaling may overcome hallmarks of chemoresistance in pancreatic cancer.

Published
2023
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12. Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer

Author

Mehra, Siddharth, primary, Garrido, Vanessa T., additional, Dosch, Austin R., additional, Lamichhane, Purushottam, additional, Srinivasan, Supriya, additional, Singh, Samara P., additional, Zhou, Zhiqun, additional, De Castro Silva, Iago, additional, Joshi, Chandrashekar, additional, Ban, Yuguang, additional, Datta, Jashodeep, additional, Gilboa, Eli, additional, Merchant, Nipun B., additional, and Nagathihalli, Nagaraj S., additional

Published
2023
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13. Data from Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer

Author

Mehra, Siddharth, primary, Garrido, Vanessa T., primary, Dosch, Austin R., primary, Lamichhane, Purushottam, primary, Srinivasan, Supriya, primary, Singh, Samara P., primary, Zhou, Zhiqun, primary, De Castro Silva, Iago, primary, Joshi, Chandrashekar, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Gilboa, Eli, primary, Merchant, Nipun B., primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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14. Figure S5 from Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer

Author

Mehra, Siddharth, primary, Garrido, Vanessa T., primary, Dosch, Austin R, primary, Lamichhane, Purushottam, primary, Srinivasan, Supriya, primary, Singh, Samara P, primary, Zhou, Zhiqun, primary, De Castro Silva, Iago, primary, Joshi, Chandrashekar, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Gilboa, Eli, primary, Merchant, Nipun B, primary, and Nagathihalli, Nagaraj S, primary

Published
2023
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15. Supplementary Tables S1-S2 from Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer

Author

Mehra, Siddharth, primary, Garrido, Vanessa T., primary, Dosch, Austin R, primary, Lamichhane, Purushottam, primary, Srinivasan, Supriya, primary, Singh, Samara P, primary, Zhou, Zhiqun, primary, De Castro Silva, Iago, primary, Joshi, Chandrashekar, primary, Ban, Yuguang, primary, Datta, Jashodeep, primary, Gilboa, Eli, primary, Merchant, Nipun B, primary, and Nagathihalli, Nagaraj S, primary

Published
2023
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16. Supplementary Materials from Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Author

Bianchi, Anna, primary, De Castro Silva, Iago, primary, Deshpande, Nilesh U., primary, Singh, Samara, primary, Mehra, Siddharth, primary, Garrido, Vanessa T., primary, Guo, Xinyu, primary, Nivelo, Luis A., primary, Kolonias, Despina S., primary, Saigh, Shannon J., primary, Wieder, Eric, primary, Rafie, Christine I., primary, Dosch, Austin R., primary, Zhou, Zhiqun, primary, Umland, Oliver, primary, Amirian, Haleh, primary, Ogobuiro, Ifeanyichukwu C., primary, Zhang, Jian, primary, Ban, Yuguang, primary, Shiau, Carina, primary, Nagathihalli, Nagaraj S., primary, Montgomery, Elizabeth A., primary, Hwang, William L., primary, Brambilla, Roberta, primary, Komanduri, Krishna, primary, Villarino, Alejandro V., primary, Toska, Eneda, primary, Stanger, Ben Z., primary, Gabrilovich, Dmitry I., primary, Merchant, Nipun B., primary, and Datta, Jashodeep, primary

Published
2023
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17. Supplementary Table S1 from Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Author

Bianchi, Anna, primary, De Castro Silva, Iago, primary, Deshpande, Nilesh U., primary, Singh, Samara, primary, Mehra, Siddharth, primary, Garrido, Vanessa T., primary, Guo, Xinyu, primary, Nivelo, Luis A., primary, Kolonias, Despina S., primary, Saigh, Shannon J., primary, Wieder, Eric, primary, Rafie, Christine I., primary, Dosch, Austin R., primary, Zhou, Zhiqun, primary, Umland, Oliver, primary, Amirian, Haleh, primary, Ogobuiro, Ifeanyichukwu C., primary, Zhang, Jian, primary, Ban, Yuguang, primary, Shiau, Carina, primary, Nagathihalli, Nagaraj S., primary, Montgomery, Elizabeth A., primary, Hwang, William L., primary, Brambilla, Roberta, primary, Komanduri, Krishna, primary, Villarino, Alejandro V., primary, Toska, Eneda, primary, Stanger, Ben Z., primary, Gabrilovich, Dmitry I., primary, Merchant, Nipun B., primary, and Datta, Jashodeep, primary

Published
2023
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18. Data from Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Author

Bianchi, Anna, primary, De Castro Silva, Iago, primary, Deshpande, Nilesh U., primary, Singh, Samara, primary, Mehra, Siddharth, primary, Garrido, Vanessa T., primary, Guo, Xinyu, primary, Nivelo, Luis A., primary, Kolonias, Despina S., primary, Saigh, Shannon J., primary, Wieder, Eric, primary, Rafie, Christine I., primary, Dosch, Austin R., primary, Zhou, Zhiqun, primary, Umland, Oliver, primary, Amirian, Haleh, primary, Ogobuiro, Ifeanyichukwu C., primary, Zhang, Jian, primary, Ban, Yuguang, primary, Shiau, Carina, primary, Nagathihalli, Nagaraj S., primary, Montgomery, Elizabeth A., primary, Hwang, William L., primary, Brambilla, Roberta, primary, Komanduri, Krishna, primary, Villarino, Alejandro V., primary, Toska, Eneda, primary, Stanger, Ben Z., primary, Gabrilovich, Dmitry I., primary, Merchant, Nipun B., primary, and Datta, Jashodeep, primary

Published
2023
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19. Data from [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study

Author

Pantel, Austin R., primary, Gitto, Sarah B., primary, Makvandi, Mehran, primary, Kim, Hyoung, primary, Medvedv, Sergey, primary, Weeks, Joanna K., primary, Torigian, Drew A., primary, Hsieh, Chia-Ju, primary, Ferman, Benjamin, primary, Latif, Nawar A., primary, Tanyi, Janos L., primary, Martin, Lainie P., primary, Lanzo, Shannon M., primary, Liu, Fang, primary, Cao, Quy, primary, Mills, Gordon B., primary, Doot, Robert K., primary, Mankoff, David A., primary, Mach, Robert H., primary, Lin, Lilie L., primary, and Simpkins, Fiona, primary

Published
2023
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20. Supplemental Figure S5 from [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study

Author

Pantel, Austin R., primary, Gitto, Sarah B., primary, Makvandi, Mehran, primary, Kim, Hyoung, primary, Medvedv, Sergey, primary, Weeks, Joanna K., primary, Torigian, Drew A., primary, Hsieh, Chia-Ju, primary, Ferman, Benjamin, primary, Latif, Nawar A., primary, Tanyi, Janos L., primary, Martin, Lainie P., primary, Lanzo, Shannon M., primary, Liu, Fang, primary, Cao, Quy, primary, Mills, Gordon B., primary, Doot, Robert K., primary, Mankoff, David A., primary, Mach, Robert H., primary, Lin, Lilie L., primary, and Simpkins, Fiona, primary

Published
2023
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22. Supplemental Table S1 from [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study

Author

Pantel, Austin R., primary, Gitto, Sarah B., primary, Makvandi, Mehran, primary, Kim, Hyoung, primary, Medvedv, Sergey, primary, Weeks, Joanna K., primary, Torigian, Drew A., primary, Hsieh, Chia-Ju, primary, Ferman, Benjamin, primary, Latif, Nawar A., primary, Tanyi, Janos L., primary, Martin, Lainie P., primary, Lanzo, Shannon M., primary, Liu, Fang, primary, Cao, Quy, primary, Mills, Gordon B., primary, Doot, Robert K., primary, Mankoff, David A., primary, Mach, Robert H., primary, Lin, Lilie L., primary, and Simpkins, Fiona, primary

Published
2023
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23. Abstract 3627: Inhibition of tumor cell-autonomous p38 MAPK suppresses IL1α-mediated inflammatory tumor-stromal crosstalk in pancreatic adenocarcinoma

Author

Singh, Samara, primary, Dosch, Austin R., additional, Mehra, Siddharth, additional, Silva, Iago de Castro, additional, Bianchi, Anna, additional, Garrido, Vanessa Tonin, additional, Zhou, Zhiqun, additional, Amirian, Haleh, additional, Box, Edmond W., additional, Datta, Jashodeep, additional, Nagathihalli, Nagaraj, additional, and Merchant, Nipun B., additional

Published
2023
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24. Abstract 5610: [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-inhibitor drug-target engagement as a biomarker of response in ovarian cancer

Author

Gitto, Sarah B., primary, Pantel, Austin R., additional, Makvandi, Mehran, additional, Kim, Hyoung, additional, Medvedev, Sergey, additional, Weeks, Joanna K., additional, Torigian, Drew A., additional, Hsieh, Chia-Ju, additional, Ferman, Benjamin, additional, Latif, Nawar A., additional, Tanyi, Janos L., additional, Martin, Lainie P., additional, Lanzo, Shannon M., additional, Liu, Fang, additional, Cao, Quy, additional, Mills, Gordon B., additional, Doot, Robert K., additional, Mankoff, David A., additional, Mach, Robert H., additional, Lin, Lilie L., additional, and Simpkins, Fiona, additional

Published
2023
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25. Supplementary Tables S1-S3 from Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

Author

Totiger, Tulasigeri M., primary, Srinivasan, Supriya, primary, Jala, Venkatakrishna R., primary, Lamichhane, Purushottam, primary, Dosch, Austin R., primary, Gaidarski, Alexander A., primary, Joshi, Chandrashekhar, primary, Rangappa, Shobith, primary, Castellanos, Jason, primary, Vemula, Praveen Kumar, primary, Chen, Xi, primary, Kwon, Deukwoo, primary, Kashikar, Nilesh, primary, VanSaun, Michael, primary, Merchant, Nipun B., primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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26. Figure S1 from E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms

Author

Jolly, Mohit Kumar, primary, Ware, Kathryn E., primary, Xu, Shengnan, primary, Gilja, Shivee, primary, Shetler, Samantha, primary, Yang, Yanjun, primary, Wang, Xueyang, primary, Austin, R. Garland, primary, Runyambo, Daniella, primary, Hish, Alexander J., primary, Bartholf DeWitt, Suzanne, primary, George, Jason T., primary, Kreulen, R. Timothy, primary, Boss, Mary-Keara, primary, Lazarides, Alexander L., primary, Kerr, David L., primary, Gerber, Drew G., primary, Sivaraj, Dharshan, primary, Armstrong, Andrew J., primary, Dewhirst, Mark W., primary, Eward, William C., primary, Levine, Herbert, primary, and Somarelli, Jason A., primary

Published
2023
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28. Supplementary Figure S2 from Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer

Author

Dosch, Austin R., primary, Dai, Xizi, primary, Reyzer, Michelle L., primary, Mehra, Siddharth, primary, Srinivasan, Supriya, primary, Willobee, Brent A., primary, Kwon, Deukwoo, primary, Kashikar, Nilesh, primary, Caprioli, Richard, primary, Merchant, Nipun B., primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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29. Data from E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms

Author

Jolly, Mohit Kumar, primary, Ware, Kathryn E., primary, Xu, Shengnan, primary, Gilja, Shivee, primary, Shetler, Samantha, primary, Yang, Yanjun, primary, Wang, Xueyang, primary, Austin, R. Garland, primary, Runyambo, Daniella, primary, Hish, Alexander J., primary, Bartholf DeWitt, Suzanne, primary, George, Jason T., primary, Kreulen, R. Timothy, primary, Boss, Mary-Keara, primary, Lazarides, Alexander L., primary, Kerr, David L., primary, Gerber, Drew G., primary, Sivaraj, Dharshan, primary, Armstrong, Andrew J., primary, Dewhirst, Mark W., primary, Eward, William C., primary, Levine, Herbert, primary, and Somarelli, Jason A., primary

Published
2023
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30. Supplementary Figure Legends from Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer

Author

Dosch, Austin R., primary, Dai, Xizi, primary, Reyzer, Michelle L., primary, Mehra, Siddharth, primary, Srinivasan, Supriya, primary, Willobee, Brent A., primary, Kwon, Deukwoo, primary, Kashikar, Nilesh, primary, Caprioli, Richard, primary, Merchant, Nipun B., primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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31. Supplementary Tables from Combined Blockade of MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma

Author

Willobee, Brent A., primary, Gaidarski, Alexander A., primary, Dosch, Austin R., primary, Castellanos, Jason A., primary, Dai, Xizi, primary, Mehra, Siddharth, primary, Messaggio, Fanuel, primary, Srinivasan, Supriya, primary, VanSaun, Michael N., primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2023
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32. Supplementary Table S1 from Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer

Author

Dosch, Austin R., primary, Dai, Xizi, primary, Reyzer, Michelle L., primary, Mehra, Siddharth, primary, Srinivasan, Supriya, primary, Willobee, Brent A., primary, Kwon, Deukwoo, primary, Kashikar, Nilesh, primary, Caprioli, Richard, primary, Merchant, Nipun B., primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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33. Data from Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

Author

Totiger, Tulasigeri M., primary, Srinivasan, Supriya, primary, Jala, Venkatakrishna R., primary, Lamichhane, Purushottam, primary, Dosch, Austin R., primary, Gaidarski, Alexander A., primary, Joshi, Chandrashekhar, primary, Rangappa, Shobith, primary, Castellanos, Jason, primary, Vemula, Praveen Kumar, primary, Chen, Xi, primary, Kwon, Deukwoo, primary, Kashikar, Nilesh, primary, VanSaun, Michael, primary, Merchant, Nipun B., primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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34. Supplementary Figures & Legends from Targeting Tumor–Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer

Author

Dosch, Austin R., primary, Singh, Samara, primary, Dai, Xizi, primary, Mehra, Siddharth, primary, Silva, Iago De Castro, primary, Bianchi, Anna, primary, Srinivasan, Supriya, primary, Gao, Zhen, primary, Ban, Yuguang, primary, Chen, Xi, primary, Banerjee, Sulagna, primary, Nagathihalli, Nagaraj S., primary, Datta, Jashodeep, primary, and Merchant, Nipun B., primary

Published
2023
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35. Supplementary Materials and Methods from Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

Author

Totiger, Tulasigeri M., primary, Srinivasan, Supriya, primary, Jala, Venkatakrishna R., primary, Lamichhane, Purushottam, primary, Dosch, Austin R., primary, Gaidarski, Alexander A., primary, Joshi, Chandrashekhar, primary, Rangappa, Shobith, primary, Castellanos, Jason, primary, Vemula, Praveen Kumar, primary, Chen, Xi, primary, Kwon, Deukwoo, primary, Kashikar, Nilesh, primary, VanSaun, Michael, primary, Merchant, Nipun B., primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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36. Supplementary Data from Combined Blockade of MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma

Author

Willobee, Brent A., primary, Gaidarski, Alexander A., primary, Dosch, Austin R., primary, Castellanos, Jason A., primary, Dai, Xizi, primary, Mehra, Siddharth, primary, Messaggio, Fanuel, primary, Srinivasan, Supriya, primary, VanSaun, Michael N., primary, Nagathihalli, Nagaraj S., primary, and Merchant, Nipun B., primary

Published
2023
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37. Supplementary Figure S1 from Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

Author

Totiger, Tulasigeri M., primary, Srinivasan, Supriya, primary, Jala, Venkatakrishna R., primary, Lamichhane, Purushottam, primary, Dosch, Austin R., primary, Gaidarski, Alexander A., primary, Joshi, Chandrashekhar, primary, Rangappa, Shobith, primary, Castellanos, Jason, primary, Vemula, Praveen Kumar, primary, Chen, Xi, primary, Kwon, Deukwoo, primary, Kashikar, Nilesh, primary, VanSaun, Michael, primary, Merchant, Nipun B., primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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38. Supplementary Tables from Targeting Tumor–Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer

Author

Dosch, Austin R., primary, Singh, Samara, primary, Dai, Xizi, primary, Mehra, Siddharth, primary, Silva, Iago De Castro, primary, Bianchi, Anna, primary, Srinivasan, Supriya, primary, Gao, Zhen, primary, Ban, Yuguang, primary, Chen, Xi, primary, Banerjee, Sulagna, primary, Nagathihalli, Nagaraj S., primary, Datta, Jashodeep, primary, and Merchant, Nipun B., primary

Published
2023
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39. Supplementary Data from E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms

Author

Jolly, Mohit Kumar, primary, Ware, Kathryn E., primary, Xu, Shengnan, primary, Gilja, Shivee, primary, Shetler, Samantha, primary, Yang, Yanjun, primary, Wang, Xueyang, primary, Austin, R. Garland, primary, Runyambo, Daniella, primary, Hish, Alexander J., primary, Bartholf DeWitt, Suzanne, primary, George, Jason T., primary, Kreulen, R. Timothy, primary, Boss, Mary-Keara, primary, Lazarides, Alexander L., primary, Kerr, David L., primary, Gerber, Drew G., primary, Sivaraj, Dharshan, primary, Armstrong, Andrew J., primary, Dewhirst, Mark W., primary, Eward, William C., primary, Levine, Herbert, primary, and Somarelli, Jason A., primary

Published
2023
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40. Supplementary Appendix from Diagnostic Performance of 18F-DCFPyL-PET/CT in Men with Biochemically Recurrent Prostate Cancer: Results from the CONDOR Phase III, Multicenter Study

Author

Morris, Michael J., primary, Rowe, Steven P., primary, Gorin, Michael A., primary, Saperstein, Lawrence, primary, Pouliot, Frédéric, primary, Josephson, David, primary, Wong, Jeffrey Y.C., primary, Pantel, Austin R., primary, Cho, Steve Y., primary, Gage, Kenneth L., primary, Piert, Morand, primary, Iagaru, Andrei, primary, Pollard, Janet H., primary, Wong, Vivien, primary, Jensen, Jessica, primary, Lin, Tess, primary, Stambler, Nancy, primary, Carroll, Peter R., primary, and Siegel, Barry A., primary

Published
2023
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42. Figure S1 from Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Author

Srinivasan, Supriya, primary, Totiger, Tulasigeri, primary, Shi, Chanjuan, primary, Castellanos, Jason, primary, Lamichhane, Purushottam, primary, Dosch, Austin R., primary, Messaggio, Fanuel, primary, Kashikar, Nilesh, primary, Honnenahally, Kumaraswamy, primary, Ban, Yuguang, primary, Merchant, Nipun B., primary, VanSaun, Michael, primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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43. Figure S1 from Diagnostic Performance of 18F-DCFPyL-PET/CT in Men with Biochemically Recurrent Prostate Cancer: Results from the CONDOR Phase III, Multicenter Study

Author

Morris, Michael J., primary, Rowe, Steven P., primary, Gorin, Michael A., primary, Saperstein, Lawrence, primary, Pouliot, Frédéric, primary, Josephson, David, primary, Wong, Jeffrey Y.C., primary, Pantel, Austin R., primary, Cho, Steve Y., primary, Gage, Kenneth L., primary, Piert, Morand, primary, Iagaru, Andrei, primary, Pollard, Janet H., primary, Wong, Vivien, primary, Jensen, Jessica, primary, Lin, Tess, primary, Stambler, Nancy, primary, Carroll, Peter R., primary, and Siegel, Barry A., primary

Published
2023
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44. Supplementary Data from Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Author

Srinivasan, Supriya, primary, Totiger, Tulasigeri, primary, Shi, Chanjuan, primary, Castellanos, Jason, primary, Lamichhane, Purushottam, primary, Dosch, Austin R., primary, Messaggio, Fanuel, primary, Kashikar, Nilesh, primary, Honnenahally, Kumaraswamy, primary, Ban, Yuguang, primary, Merchant, Nipun B., primary, VanSaun, Michael, primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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45. Supplemental Methods and Supplemenal Figures 1 through 5 from [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition

Author

Zhou, Rong, primary, Pantel, Austin R., primary, Li, Shihong, primary, Lieberman, Brian P., primary, Ploessl, Karl, primary, Choi, Hoon, primary, Blankemeyer, Eric, primary, Lee, Hsiaoju, primary, Kung, Hank F., primary, Mach, Robert H., primary, and Mankoff, David A., primary

Published
2023
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46. Data from Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Author

Srinivasan, Supriya, primary, Totiger, Tulasigeri, primary, Shi, Chanjuan, primary, Castellanos, Jason, primary, Lamichhane, Purushottam, primary, Dosch, Austin R., primary, Messaggio, Fanuel, primary, Kashikar, Nilesh, primary, Honnenahally, Kumaraswamy, primary, Ban, Yuguang, primary, Merchant, Nipun B., primary, VanSaun, Michael, primary, and Nagathihalli, Nagaraj S., primary

Published
2023
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47. Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Author

Bianchi, Anna, primary, De Castro Silva, Iago, additional, Deshpande, Nilesh U., additional, Singh, Samara, additional, Mehra, Siddharth, additional, Garrido, Vanessa T., additional, Guo, Xinyu, additional, Nivelo, Luis A., additional, Kolonias, Despina S., additional, Saigh, Shannon J., additional, Wieder, Eric, additional, Rafie, Christine I., additional, Dosch, Austin R., additional, Zhou, Zhiqun, additional, Umland, Oliver, additional, Amirian, Haleh, additional, Ogobuiro, Ifeanyichukwu C., additional, Zhang, Jian, additional, Ban, Yuguang, additional, Shiau, Carina, additional, Nagathihalli, Nagaraj S., additional, Montgomery, Elizabeth A., additional, Hwang, William L., additional, Brambilla, Roberta, additional, Komanduri, Krishna, additional, Villarino, Alejandro V., additional, Toska, Eneda, additional, Stanger, Ben Z., additional, Gabrilovich, Dmitry I., additional, Merchant, Nipun B., additional, and Datta, Jashodeep, additional

Published
2023
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48. Data from Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Author

Jashodeep Datta, Nipun B. Merchant, Dmitry I. Gabrilovich, Ben Z. Stanger, Eneda Toska, Alejandro V. Villarino, Krishna Komanduri, Roberta Brambilla, William L. Hwang, Elizabeth A. Montgomery, Nagaraj S. Nagathihalli, Carina Shiau, Yuguang Ban, Jian Zhang, Ifeanyichukwu C. Ogobuiro, Haleh Amirian, Oliver Umland, Zhiqun Zhou, Austin R. Dosch, Christine I. Rafie, Eric Wieder, Shannon J. Saigh, Despina S. Kolonias, Luis A. Nivelo, Xinyu Guo, Vanessa T. Garrido, Siddharth Mehra, Samara Singh, Nilesh U. Deshpande, Iago De Castro Silva, and Anna Bianchi

Abstract

We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded microenvironments, chemoresistance, and poor survival in pancreatic ductal adenocarcinoma (PDAC) patients. By treating KRAS–TP53 cooperativity as a model for high-risk biology, we now identify cell-autonomous Cxcl1 as a key mediator of spatial T-cell restriction via interactions with CXCR2+ neutrophilic myeloid-derived suppressor cells in human PDAC using imaging mass cytometry. Silencing of cell-intrinsic Cxcl1 in LSL-KrasG12D/+;Trp53R172H/+;Pdx-1Cre/+(KPC) cells reprograms the trafficking and functional dynamics of neutrophils to overcome T-cell exclusion and controls tumor growth in a T cell–dependent manner. Mechanistically, neutrophil-derived TNF is a central regulator of this immunologic rewiring, instigating feed-forward Cxcl1 overproduction from tumor cells and cancer-associated fibroblasts (CAF), T-cell dysfunction, and inflammatory CAF polarization via transmembrane TNF–TNFR2 interactions. TNFR2 inhibition disrupts this circuitry and improves sensitivity to chemotherapy in vivo. Our results uncover cancer cell–neutrophil cross-talk in which context-dependent TNF signaling amplifies stromal inflammation and immune tolerance to promote therapeutic resistance in PDAC.Significance:By decoding connections between high-risk tumor genotypes, cell-autonomous inflammatory programs, and myeloid-enriched/T cell–excluded contexts, we identify a novel role for neutrophil-derived TNF in sustaining immunosuppression and stromal inflammation in pancreatic tumor microenvironments. This work offers a conceptual framework by which targeting context-dependent TNF signaling may overcome hallmarks of chemoresistance in pancreatic cancer.

Published
2023
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49. Supplementary Table S1 from Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Author

Jashodeep Datta, Nipun B. Merchant, Dmitry I. Gabrilovich, Ben Z. Stanger, Eneda Toska, Alejandro V. Villarino, Krishna Komanduri, Roberta Brambilla, William L. Hwang, Elizabeth A. Montgomery, Nagaraj S. Nagathihalli, Carina Shiau, Yuguang Ban, Jian Zhang, Ifeanyichukwu C. Ogobuiro, Haleh Amirian, Oliver Umland, Zhiqun Zhou, Austin R. Dosch, Christine I. Rafie, Eric Wieder, Shannon J. Saigh, Despina S. Kolonias, Luis A. Nivelo, Xinyu Guo, Vanessa T. Garrido, Siddharth Mehra, Samara Singh, Nilesh U. Deshpande, Iago De Castro Silva, and Anna Bianchi

Abstract

Differentially expressed pathways comparing transcriptomes in KRAS-TP53 co-altered (n=23) and KRAS-altered/TP53WT (n=5) derived from Cancer Cell Line Encyclopedia

Published
2023
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50. Supplemental Figure S1 from [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study

Author

Fiona Simpkins, Lilie L. Lin, Robert H. Mach, David A. Mankoff, Robert K. Doot, Gordon B. Mills, Quy Cao, Fang Liu, Shannon M. Lanzo, Lainie P. Martin, Janos L. Tanyi, Nawar A. Latif, Benjamin Ferman, Chia-Ju Hsieh, Drew A. Torigian, Joanna K. Weeks, Sergey Medvedv, Hyoung Kim, Mehran Makvandi, Sarah B. Gitto, and Austin R. Pantel

Abstract

PDX models treated with PARPi therapies.

Published
2023
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