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Your search keyword '"Pinto, Navin"' showing total 6 results
Start Over Author "Pinto, Navin" Publisher american association for cancer research
6 results on '"Pinto, Navin"'

1. Abstract B13: Leveraging cloud-based computational resources for gene fusion discovery with potential clinical implications for pediatric solid tumor patients

Author

Imamovic, Alma, primary, Church, Alanna J., additional, Corson, Laura B., additional, Reidy, Deirdre, additional, Pinto, Navin, additional, Maese, Luke, additional, Laetsch, Theodore W., additional, Kim, AeRang, additional, Vear, Susan I., additional, Macy, Margaret E., additional, Applebaum, Mark A., additional, Bagatell, Rochelle, additional, Sabnis, Amit J., additional, Weiser, Daniel A., additional, Glade-Bender, Julia L., additional, Strand, Gianna R., additional, Lee, Lobin A., additional, Pinches, R. Seth, additional, Clinton, Catherine M., additional, Crompton, Brian D., additional, Lindeman, Neal I., additional, DuBois, Steven G., additional, Janeway, Katherine A., additional, and Van Allen, Eliezer M., additional

Published
2020
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2. Abstract A59: Sequencing identifies diagnostically relevant alterations in pediatric solid tumor patients

Author

Church, Alanna J., primary, Corson, Laura B., additional, Imamovic-Tuco, Alma, additional, Strand, Gianna R., additional, Reidy, Dierdre, additional, Doan, Duong, additional, Pinches, Robert S., additional, Applebaum, Mark A., additional, Bagatell, Rochelle, additional, Crompton, Brian D., additional, DuBois, Steven G., additional, Bender, Julia L. Glade, additional, Laetsch, Theodore W., additional, Lee, Lobin A., additional, Lindeman, Neal I., additional, Harris, Marian H., additional, Macy, Margaret E., additional, Maese, Luke, additional, Pinto, Navin, additional, Sabnis, Amit J., additional, Van Allen, Eliezer M., additional, Vear, Susan I., additional, Weiser, Daniel A., additional, Clinton, Catherine M., additional, and Janeway, Katherine A., additional

Published
2020
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3. Abstract A28: Targeted sequencing in 388 patients with high-risk or recurrent/refractory pediatric extracranial solid malignancies: An interim report from the GAIN Consortium/iCat2 Study

Author

Corson, Laura B., primary, Church, Alanna J., additional, Reidy, Deirdre, additional, Kao, Pei-Chi, additional, Kang, Wenjun, additional, Pinto, Navin, additional, Maese, Luke, additional, Laetsch, Theodore W., additional, Kim, AeRang, additional, Vear, Susan I., additional, Macy, Margaret E., additional, Applebaum, Mark A., additional, Lee, Lobin A., additional, Doan, Duong, additional, Pinches, R. Seth, additional, Choi, Seong, additional, Forrest, Suzanne J., additional, Clinton, Catherine M., additional, Crompton, Brian D., additional, MacConaill, Laura E., additional, Volchenboum, Samuel L., additional, Lindeman, Neal I., additional, DuBois, Steven G., additional, London, Wendy B., additional, and Janeway, Katherine A., additional

Published
2020
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4. Abstract A06: The added value of examining germline variants in a precision cancer therapy study

Author

Schienda, Jaclyn, primary, Clinton, Catherine M., additional, Corson, Laura B., additional, Imamovic-Tuco, Alma, additional, Pinto, Navin, additional, Maese, Luke, additional, Laetsch, Theodore W., additional, Kim, AeRang, additional, Vear, Susan I., additional, Macy, Margaret E., additional, Applebaum, Mark A., additional, Bagatell, Rochelle, additional, Sabnis, Amit J., additional, Weiser, Daniel A., additional, Glade-Bender, Julia L., additional, Volchenboum, Samuel L., additional, Kang, Wenjun, additional, Manning, Danielle, additional, Nowak, Jonathan, additional, Schiffman, Joshua, additional, Lindeman, Neal I., additional, Church, Alanna J., additional, Janeway, Katherine A., additional, Crompton, Brian D., additional, and Kamihara, Junne, additional

Published
2020
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5. Abstract 3104: A high prevalence of chromosomal translocations as drivers in high-risk pediatric solid cancers

Author

Corson, Laura B., primary, Imamovic-Tuco, Alma, additional, Strand, Gianna R., additional, Reidy, Deirdre, additional, Doan, Duong, additional, Applebaum, Mark A., additional, Bagatell, Rochelle, additional, Crompton, Brian D., additional, DuBois, Steven G., additional, Bender, Julia L. Glade, additional, Kim, AeRang, additional, Laetsch, Theodore W., additional, Lee, Lobin A., additional, Lindeman, Neal I., additional, MacConaill, Laura E., additional, Macy, Margaret E., additional, Maese, Luke, additional, Pinches, Seth, additional, Pinto, Navin, additional, Sabnis, Amit J., additional, Allen, Eliezer M. Van, additional, Vear, Susan I., additional, Weiser, Daniel A., additional, Clinton, Catherine M., additional, Janeway, Katherine A., additional, and Church, Alanna J., additional

Published
2019
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6. Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety.

Author

Vitanza NA, Wilson AL, Huang W, Seidel K, Brown C, Gustafson JA, Yokoyama JK, Johnson AJ, Baxter BA, Koning RW, Reid AN, Meechan M, Biery MC, Myers C, Rawlings-Rhea SD, Albert CM, Browd SR, Hauptman JS, Lee A, Ojemann JG, Berens ME, Dun MD, Foster JB, Crotty EE, Leary SES, Cole BL, Perez FA, Wright JN, Orentas RJ, Chour T, Newell EW, Whiteaker JR, Zhao L, Paulovich AG, Pinto N, Gust J, Gardner RA, Jensen MC, and Park JR

Subjects
Humans, B7 Antigens, T-Lymphocytes, Diffuse Intrinsic Pontine Glioma, Brain Stem Neoplasms therapy
Abstract

Diffuse intrinsic pontine glioma (DIPG) remains a fatal brainstem tumor demanding innovative therapies. As B7-H3 (CD276) is expressed on central nervous system (CNS) tumors, we designed B7-H3-specific chimeric antigen receptor (CAR) T cells, confirmed their preclinical efficacy, and opened BrainChild-03 (NCT04185038), a first-in-human phase I trial administering repeated locoregional B7-H3 CAR T cells to children with recurrent/refractory CNS tumors and DIPG. Here, we report the results of the first three evaluable patients with DIPG (including two who enrolled after progression), who received 40 infusions with no dose-limiting toxicities. One patient had sustained clinical and radiographic improvement through 12 months on study. Patients exhibited correlative evidence of local immune activation and persistent cerebrospinal fluid (CSF) B7-H3 CAR T cells. Targeted mass spectrometry of CSF biospecimens revealed modulation of B7-H3 and critical immune analytes (CD14, CD163, CSF-1, CXCL13, and VCAM-1). Our data suggest the feasibility of repeated intracranial B7-H3 CAR T-cell dosing and that intracranial delivery may induce local immune activation., Significance: This is the first report of repeatedly dosed intracranial B7-H3 CAR T cells for patients with DIPG and includes preliminary tolerability, the detection of CAR T cells in the CSF, CSF cytokine elevations supporting locoregional immune activation, and the feasibility of serial mass spectrometry from both serum and CSF. This article is highlighted in the In This Issue feature, p. 1., (©2022 The Authors; Published by the American Association for Cancer Research.)

Published
2023
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