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Your search keyword '"Noma, Kazuhiro"' showing total 20 results
Start Over Author "Noma, Kazuhiro" Publisher american association for cancer research
20 results on '"Noma, Kazuhiro"'

1. Abstract CT185: Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (telomelysin) with radiotherapy in esophageal cancer patients unfit for standard treatments

Author

Fujiwara, Toshiyoshi, primary, Tanabe, Shunsuke, additional, Tazawa, Hiroshi, additional, Kanaya, Nobuhiko, additional, Noma, Kazuhiro, additional, Kagawa, Shunsuke, additional, Kuroda, Shinji, additional, Urata, Yasuo, additional, and Shirakawa, Yasuhiro, additional

Published
2019
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2. Abstract 1155: Stemness control by iron chelator is a novel therapeutic strategy for esophageal cancer

Author

Narusaka, Toru, primary, Ohara, Toshiaki, additional, Noma, Kazuhiro, additional, Katsura, Yuki, additional, Nishiwaki, Noriyuki, additional, Tabuchi, Motoyasu, additional, Fushimi, Takuro, additional, Ogawa, Toshihiro, additional, Takeda, Sho, additional, Komoto, Satoshi, additional, Sato, Hiroaki, additional, Kikuchi, Satoru, additional, Tomono, Yasuko, additional, Tazawa, Hiroshi, additional, Kagawa, Shunsuke, additional, Shirakawa, Yasuhiro, additional, and Fujiwara, Toshiyoshi, additional

Published
2019
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3. Abstract 2979: Boosting replication and penetration of telomerase-specific replicative virus by paclitaxel induces synthetic lethality in peritoneal metastasis of gastric cancer

Author

Ogawa, Toshihiro, primary, Kikuchi, Satoru, additional, Ishikawa, Wataru, additional, Tazawa, Hiroshi, additional, Tabuchi, Motoyasu, additional, Kuroda, Shinji, additional, Noma, Kazuhiro, additional, Nishizaki, Masahiko, additional, Kagawa, Shunsuke, additional, Urata, Yasuo, additional, and Fujiwara, Toshiyoshi, additional

Published
2019
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4. Abstract LB-310: Overcoming resistance of conventional therapies by targeting cancer-associated fibroblasts (CAFs) with near-infrared photoimmunotherapy (NIR-PIT)

Author

Komoto, Satoshi, primary, Noma, Kazuhiro, additional, Katsube, Ryoichi, additional, Kato, Takuya, additional, Ohara, Toshiaki, additional, Sato, Hiroaki, additional, Narusaka, Toru, additional, Nisiwaki, Noriyuki, additional, Tazawa, Hiroshi, additional, Shirakawa, Yasuhiro, additional, and Fujiwara, Toshiyoshi, additional

Published
2019
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5. Abstract 4330: Activation ofAZIN1RNA editing facilitates and promotes invasive potential of cancer associated fibroblasts in colorectal cancer

Author

Takeda, Sho, primary, Shigeyasu, Kunitoshi, additional, Okugawa, Yoshinaga, additional, Yoshida, Kazuhiro, additional, Mori, Yoshiko, additional, Yano, Shuya, additional, Noma, Kazuhiro, additional, Umeda, Yuzo, additional, Kondo, Yoshitaka, additional, Kishimoto, Hiroyuki, additional, Teraishi, Fuminori, additional, Tazawa, Hiroshi, additional, Kagawa, Shunsuke, additional, Goel, Ajay, additional, and Fujiwara, Toshiyoshi, additional

Published
2019
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7. Abstract 5066: Dual-targeting photoimmunotherapy (NIR-PIT) for esophageal cancer cells and cancer-associated fibroblasts (CAFs)

Author

Sato, Hiroaki, primary, Noma, Kazuhiro, additional, Narusaka, Toru, additional, Komoto, Satoshi, additional, Katsura, Yuki, additional, Kato, Takuya, additional, Ninomiya, Takayuki, additional, Ohara, Toshiaki, additional, Tazawa, Hiroshi, additional, Shirakawa, Yasuhiro, additional, Kobayashi, Hisataka, additional, and Fujiwara, Toshiyoshi, additional

Published
2018
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8. Abstract 4807: Novel theranostic strategy against peritoneal metastasis of scirrhous gastric cancer: Combination with fluorescence oncolytic adenovirus and chemotherapy

Author

Ishikawa, Wataru, primary, Kikuchi, Satoru, additional, Tazawa, Hiroshi, additional, Ohara, Toshiaki, additional, Kuroda, Shinji, additional, Noma, Kazuhiro, additional, Kishimoto, Hiroyuki, additional, Nishizaki, Masahiko, additional, Urata, Yasuo, additional, Kagawa, Shunsuke, additional, and Fujiwara, Toshiyoshi, additional

Published
2018
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10. Abstract LB-045: Iron depletion suppress the stemness markers and functions of cancer stem cells

Author

Ohara, Toshiaki, primary, Katsura, Yuki, additional, Noma, Kazuhiro, additional, Narusaka, Toru, additional, Kato, Takuya, additional, Sato, Hiroaki, additional, Komoto, Satoshi, additional, Tomono, Yasuko, additional, Ninomiya, Takayuki, additional, Tazawa, Hiroshi, additional, Kagawa, Shunsuke, additional, Shirakawa, Yasuhiro, additional, and Fujiwara, Toshiyoshi, additional

Published
2018
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11. Abstract 1101: Visualization of epithelial-mesenchymal transition in inflammatory microenvironment-colorectal cancer network in vitro and in vivo

Author

Tazawa, Hiroshi, primary, Ieda, Takeshi, additional, Yano, Shuya, additional, Kikuchi, Satoru, additional, Kuroda, Shinji, additional, Ohara, Toshiaki, additional, Noma, Kazuhiro, additional, Kishimoto, Hiroyuki, additional, Nishizaki, Masahiko, additional, Kagawa, Shunsuke, additional, Saitou, Takashi, additional, Imamura, Takeshi, additional, and Fujiwara, Toshiyoshi, additional

Published
2018
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12. Abstract 5809: Fluorescence-guided spatiotemporal dynamics of epithelial-mesenchymal transition under inflammatory microenvironment during colorectal cancer progression

Author

Ieda, Takeshi, primary, Tazawa, Hiroshi, additional, Kikuchi, Satoru, additional, Kuroda, Shinji, additional, Ohara, Toshiaki, additional, Noma, Kazuhiro, additional, Kishimoto, Hiroyuki, additional, Nagasaka, Takeshi, additional, Nishizaki, Masahiko, additional, Kagawa, Shunsuke, additional, Imamura, Takeshi, additional, and Fujiwara, Toshiyoshi, additional

Published
2017
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13. Abstract 925: Tumorigenesis of murine iPS cell is prevented by iron depletion with downregulation of stemness markers

Author

Katsura, Yuki, primary, Ohara, Toshiaki, additional, Kashima, Hajime, additional, Sato, Hiroaki, additional, Kato, Takuya, additional, Ninomiya, Takayuki, additional, Noma, Kazuhiro, additional, Tomono, Yasuko, additional, Tazawa, Hiroshi, additional, Kagawa, Shunsuke, additional, Shirakawa, Yasuhiro, additional, and Fujiwara, Toshiyoshi, additional

Published
2017
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15. Abstract 1560: Correlation of FAP(fibroblast activation protein)-expressing cancer associated fibroblasts (CAFs) and tumor metastasis in esophageal carcinoma

Author

Kashima, Hajime, primary, Noma, Kazuhiro, additional, Katsura, Yuki, additional, Kato, Takuya, additional, Katsube, Ryoichi, additional, Ninomiya, Takayuki, additional, Ohara, Toshiaki, additional, Tazawa, Hiroshi, additional, Kagawa, Shunsuke, additional, Shirakawa, Yasuhiro, additional, and Fujiwara, Toshiyoshi, additional

Published
2016
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18. Abstract 401: A novel photoimmunotherapy targeting cancer-associated fibroblasts (CAFs) overcomes therapeutic resistance in human esophageal cancer

Author

Katsube, Ryoichi, primary, Noma, Kazuhiro, additional, Watanabe, Shinichiro, additional, Urano, Shinichi, additional, Ninomiya, Takayuki, additional, Ohara, Toshiaki, additional, Tazawa, Hiroshi, additional, Kagawa, Shunsuke, additional, Kobayashi, Hisataka, additional, and Fujiwara, Toshiyoshi, additional

Published
2015
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19. Abstract 4243: Iron control is a novel therapeutic target of cancer stem cells

Author

Ninomiya, Takayuki, primary, Ohara, Toshiaki, additional, Kashima, Hajime, additional, Katsube, Ryoichi, additional, Noma, Kazuhiro, additional, Tomono, Yasuko, additional, Mizutani, Akifumi, additional, Kasai, Tomonari, additional, Seno, Masaharu, additional, Kuroda, Shinji, additional, Kishimoto, Hiroyuki, additional, Tazawa, Hiroshi, additional, Shirakawa, Yasuhiro, additional, Kagawa, Shunsuke, additional, and Fujiwara, Toshiyoshi, additional

Published
2015
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20. Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery.

Author

Kuroda S, Fujiwara T, Shirakawa Y, Yamasaki Y, Yano S, Uno F, Tazawa H, Hashimoto Y, Watanabe Y, Noma K, Urata Y, Kagawa S, and Fujiwara T

Subjects
Acid Anhydride Hydrolases, Adenoviridae metabolism, Adenovirus E1B Proteins metabolism, Animals, Apoptosis genetics, Apoptosis radiation effects, Blotting, Western, Cell Cycle Proteins metabolism, Cell Line, Tumor, Cell Survival genetics, Cell Survival radiation effects, Combined Modality Therapy, DNA Breaks, Double-Stranded radiation effects, DNA Repair Enzymes metabolism, DNA-Binding Proteins metabolism, Esophageal Neoplasms genetics, Esophageal Neoplasms therapy, Female, Flow Cytometry, Humans, MRE11 Homologue Protein, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasms genetics, Nuclear Proteins metabolism, Radiation, Ionizing, Telomerase genetics, Xenograft Model Antitumor Assays, Adenoviridae genetics, DNA Repair radiation effects, Neoplasms therapy, Oncolytic Virotherapy methods, Telomerase metabolism
Abstract

The inability to repair DNA double-strand breaks (DSB) leads to radiosensitization, such that ionizing radiation combined with molecular inhibition of cellular DSB processing may greatly affect treatment of human cancer. As a variety of viral products interact with the DNA repair machinery, oncolytic virotherapy may improve the therapeutic window of conventional radiotherapy. Here, we describe the mechanistic basis for synergy of irradiation and OBP-301 (Telomelysin), an attenuated type-5 adenovirus with oncolytic potency that contains the human telomerase reverse transcriptase promoter to regulate viral replication. OBP-301 infection led to E1B55kDa viral protein expression that degraded the complex formed by Mre11, Rad50, and NBS1, which senses DSBs. Subsequently, the phosphorylation of cellular ataxia-telangiectasia mutated protein was inhibited, disrupting the signaling pathway controlling DNA repair. Thus, tumor cells infected with OBP-301 could be rendered sensitive to ionizing radiation. Moreover, by using noninvasive whole-body imaging, we showed that intratumoral injection of OBP-301 followed by regional irradiation induces a substantial antitumor effect, resulting from tumor cell-specific radiosensitization, in an orthotopic human esophageal cancer xenograft model. These results illustrate the potential of combining oncolytic virotherapy and ionizing radiation as a promising strategy in the management of human cancer., (Copyright © 2010 AACR.)

Published
2010
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