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Your search keyword '"Mariotti, Veronica"' showing total 5 results
Start Over Author "Mariotti, Veronica" Publisher american association for cancer research
5 results on '"Mariotti, Veronica"'

1. Abstract PS5-10:Esr1mutation as a potential predictor of abemaciclib benefit following prior cdk4/6 inhibitor (cdk4/6i) progression in hormone receptor-positive (hr+) metastatic breast cancer (mbc): A translational investigation

Author

Wander, Seth A., primary, Han, Hyo S., additional, Johnson, Gabriela N., additional, Lloyd, Maxwell R., additional, Mao, Pingping, additional, Nayar, Utthara, additional, Kowalski, Kailey, additional, Stein, Casey R., additional, Mariotti, Veronica, additional, Kim, Leslie SL, additional, Levin, Maren, additional, Xi, Jing, additional, Pandey, Apurva, additional, Dunne, Siobhan, additional, Nasrazadani, Azadeh, additional, Brufsky, Adam, additional, Kalinsky, Kevin, additional, Ma, Cynthia X, additional, O’Shaughnessy, Joyce, additional, Wagle, Nikhil, additional, and Bardia, Aditya, additional

Published
2021
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3. Abstract PD1-04: Results of a phase II double-blinded, randomized, placebo-controlled clinical trial of Indoximod, an Indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, in combination with Taxane chemotherapy in metastatic breast cancer (MBC)

Author

Mariotti, Veronica, primary, Tang, Shou-Ching, additional, Dillon, Patrick, additional, Montero, Alberto, additional, Poklepovic, Andrew, additional, Melin, Susan, additional, Nuhad, Ibrahim, additional, Nikolinakos, Petros, additional, Kennedy, Eugene, additional, Han, Hyo, additional, Ismail-Khan, Roohi, additional, Bruetman, Daniel, additional, Danciu, Oana, additional, Gilman, Paul, additional, Karaszewska, Boguslawa, additional, Lesniewski-Kmak, Krzysztof, additional, Panella, Timothy, additional, Patel, Dhimant, additional, Suszko-Kazarnowicz, Malgorzata, additional, Volterra, Fabio, additional, and Soliman, Hatem, additional

Published
2020
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5. A novel model of dormancy for bone metastatic breast cancer cells.

Author

Marlow R, Honeth G, Lombardi S, Cariati M, Hessey S, Pipili A, Mariotti V, Buchupalli B, Foster K, Bonnet D, Grigoriadis A, Rameshwar P, Purushotham A, Tutt A, and Dontu G

Subjects
Animals, Bone Marrow Cells physiology, Cell Cycle Checkpoints physiology, Cells, Cultured, Female, Human Umbilical Vein Endothelial Cells physiology, Humans, MCF-7 Cells, Mice, Mice, Inbred NOD, Mice, SCID, Neoplastic Stem Cells pathology, Stem Cell Niche physiology, Stromal Cells physiology, Bone Neoplasms secondary, Breast Neoplasms pathology, Models, Biological, Neoplastic Stem Cells physiology, Tumor Microenvironment physiology
Abstract

Mortality of patients with breast cancer is due overwhelmingly to metastatic spread of the disease. Although dissemination is an early event in breast cancer, extended periods of cancer cell dormancy can result in long latency of metastasis development. Deciphering the mechanisms underlying cancer cell dormancy and subsequent growth at the metastatic site would facilitate development of strategies to interfere with these processes. A challenge in this undertaking has been the lack of models for cancer cell dormancy. We have established novel experimental systems that model the bone microenvironment of the breast cancer metastatic niche. These systems are based on 3D cocultures of breast cancer cells with cell types predominant in bone marrow. We identified conditions in which cancer cells are dormant and conditions in which they proliferate. Dormant cancer cells were able to proliferate upon transfer into supportive microenvironment or upon manipulation of signaling pathways that control dormancy. These experimental systems will be instrumental for metastasis studies, particularly the study of cellular dormancy.

Published
2013
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