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Your search keyword '"Maese, Luke"' showing total 11 results
Start Over Author "Maese, Luke" Publisher american association for cancer research
11 results on '"Maese, Luke"'

1. Abstract B13: Leveraging cloud-based computational resources for gene fusion discovery with potential clinical implications for pediatric solid tumor patients

Author

Imamovic, Alma, primary, Church, Alanna J., additional, Corson, Laura B., additional, Reidy, Deirdre, additional, Pinto, Navin, additional, Maese, Luke, additional, Laetsch, Theodore W., additional, Kim, AeRang, additional, Vear, Susan I., additional, Macy, Margaret E., additional, Applebaum, Mark A., additional, Bagatell, Rochelle, additional, Sabnis, Amit J., additional, Weiser, Daniel A., additional, Glade-Bender, Julia L., additional, Strand, Gianna R., additional, Lee, Lobin A., additional, Pinches, R. Seth, additional, Clinton, Catherine M., additional, Crompton, Brian D., additional, Lindeman, Neal I., additional, DuBois, Steven G., additional, Janeway, Katherine A., additional, and Van Allen, Eliezer M., additional

Published
2020
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2. Abstract A59: Sequencing identifies diagnostically relevant alterations in pediatric solid tumor patients

Author

Church, Alanna J., primary, Corson, Laura B., additional, Imamovic-Tuco, Alma, additional, Strand, Gianna R., additional, Reidy, Dierdre, additional, Doan, Duong, additional, Pinches, Robert S., additional, Applebaum, Mark A., additional, Bagatell, Rochelle, additional, Crompton, Brian D., additional, DuBois, Steven G., additional, Bender, Julia L. Glade, additional, Laetsch, Theodore W., additional, Lee, Lobin A., additional, Lindeman, Neal I., additional, Harris, Marian H., additional, Macy, Margaret E., additional, Maese, Luke, additional, Pinto, Navin, additional, Sabnis, Amit J., additional, Van Allen, Eliezer M., additional, Vear, Susan I., additional, Weiser, Daniel A., additional, Clinton, Catherine M., additional, and Janeway, Katherine A., additional

Published
2020
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3. Abstract A28: Targeted sequencing in 388 patients with high-risk or recurrent/refractory pediatric extracranial solid malignancies: An interim report from the GAIN Consortium/iCat2 Study

Author

Corson, Laura B., primary, Church, Alanna J., additional, Reidy, Deirdre, additional, Kao, Pei-Chi, additional, Kang, Wenjun, additional, Pinto, Navin, additional, Maese, Luke, additional, Laetsch, Theodore W., additional, Kim, AeRang, additional, Vear, Susan I., additional, Macy, Margaret E., additional, Applebaum, Mark A., additional, Lee, Lobin A., additional, Doan, Duong, additional, Pinches, R. Seth, additional, Choi, Seong, additional, Forrest, Suzanne J., additional, Clinton, Catherine M., additional, Crompton, Brian D., additional, MacConaill, Laura E., additional, Volchenboum, Samuel L., additional, Lindeman, Neal I., additional, DuBois, Steven G., additional, London, Wendy B., additional, and Janeway, Katherine A., additional

Published
2020
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4. Abstract A06: The added value of examining germline variants in a precision cancer therapy study

Author

Schienda, Jaclyn, primary, Clinton, Catherine M., additional, Corson, Laura B., additional, Imamovic-Tuco, Alma, additional, Pinto, Navin, additional, Maese, Luke, additional, Laetsch, Theodore W., additional, Kim, AeRang, additional, Vear, Susan I., additional, Macy, Margaret E., additional, Applebaum, Mark A., additional, Bagatell, Rochelle, additional, Sabnis, Amit J., additional, Weiser, Daniel A., additional, Glade-Bender, Julia L., additional, Volchenboum, Samuel L., additional, Kang, Wenjun, additional, Manning, Danielle, additional, Nowak, Jonathan, additional, Schiffman, Joshua, additional, Lindeman, Neal I., additional, Church, Alanna J., additional, Janeway, Katherine A., additional, Crompton, Brian D., additional, and Kamihara, Junne, additional

Published
2020
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5. Abstract 3104: A high prevalence of chromosomal translocations as drivers in high-risk pediatric solid cancers

Author

Corson, Laura B., primary, Imamovic-Tuco, Alma, additional, Strand, Gianna R., additional, Reidy, Deirdre, additional, Doan, Duong, additional, Applebaum, Mark A., additional, Bagatell, Rochelle, additional, Crompton, Brian D., additional, DuBois, Steven G., additional, Bender, Julia L. Glade, additional, Kim, AeRang, additional, Laetsch, Theodore W., additional, Lee, Lobin A., additional, Lindeman, Neal I., additional, MacConaill, Laura E., additional, Macy, Margaret E., additional, Maese, Luke, additional, Pinches, Seth, additional, Pinto, Navin, additional, Sabnis, Amit J., additional, Allen, Eliezer M. Van, additional, Vear, Susan I., additional, Weiser, Daniel A., additional, Clinton, Catherine M., additional, Janeway, Katherine A., additional, and Church, Alanna J., additional

Published
2019
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6. Abstract 2704: Pathogenic mutations and variants of unknown significance (VUS) in cancer predisposition genes are associated with over 10% of pediatric rhabdomyosarcoma: a report from the Children’s Oncology Group

Author

Young, Erin L., primary, Maese, Luke, additional, Robinson, Rosann, additional, Pflieger, Lance, additional, Moore, Barry, additional, Rynearson, Shawn, additional, Fowler, Trent, additional, Tavtigian, Sean V., additional, Yandell, Mark, additional, Mason, Clinton C., additional, Hawkins, Douglas S., additional, Lupo, Philip J., additional, and Schiffman, Joshua D., additional

Published
2017
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7. Abstract 4884: Focal 22q11.22 deletions combined withIKZF1alterations are associated with worse clinical outcome in acute lymphoblastic leukemia

Author

Meyer, Julia A., primary, Mason, Clint C., additional, Maese, Luke, additional, Pei, Deqing, additional, Cheng, Cheng, additional, Pui, Ching-Hon, additional, Greaves, Mel, additional, Aplenc, Richard, additional, Mulligan, Charles G., additional, Raetz, Elizabeth, additional, Miles, Rodney R., additional, Rabin, Karen R., additional, and Schiffman, Joshua D., additional

Published
2017
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8. Abstract 2706:KRT16germline mutation associated with familial syndrome of tylosis with esophageal cancer (TOC)

Author

Young, Erin L., primary, Pflieger, Lance, additional, Maese, Luke, additional, Fowler, Trent, additional, Garfield, Kinley, additional, Samadder, N. Jewel, additional, Johnson, Bella, additional, Mason, Clinton C., additional, Moore, Barry, additional, Ryanearson, Shawn, additional, Yandell, Mark, additional, Kohlmann, Wendy, additional, and Schiffman, Joshua D., additional

Published
2017
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9. Update on Recommendations for Cancer Screening and Surveillance in Children with Genomic Instability Disorders.

Author

Nakano Y, Kuiper RP, Nichols KE, Porter CC, Lesmana H, Meade J, Kratz CP, Godley LA, Maese LD, Achatz MI, Khincha PP, Savage SA, Doria AS, Greer MC, Chang VY, Wang LL, Plon SE, and Walsh MF

Subjects
Humans, Child, Genetic Predisposition to Disease, Practice Guidelines as Topic, Genomic Instability, Neoplasms genetics, Neoplasms diagnosis, Neoplasms therapy, Early Detection of Cancer methods
Abstract

Genomic instability disorders are characterized by DNA or chromosomal instability, resulting in various clinical manifestations, including developmental anomalies, immunodeficiency, and increased risk of developing cancers beginning in childhood. Many of these genomic instability disorders also present with exquisite sensitivity to anticancer treatments such as ionizing radiation and chemotherapy, which may further increase the risk of second cancers. In July 2023, the American Association for Cancer Research held the second Childhood Cancer Predisposition Workshop, where multidisciplinary international experts discussed, reviewed, and updated recommendations for children with cancer predisposition syndromes. This article discusses childhood cancer risks and surveillance recommendations for the group of genomic instability disorders with predominantly recessive inheritance, including the DNA repair disorders ataxia telangiectasia, Nijmegen breakage syndrome, Fanconi anemia, xeroderma pigmentosum, Bloom syndrome, and Rothmund-Thomson syndrome, as well as the telomere biology disorders and mosaic variegated aneuploidy. Recognition of children with genomic instability disorders is important in order to make the proper diagnosis, enable genetic counseling, and inform cancer screening, cancer risk reduction, and choice of anticancer therapy., (©2024 American Association for Cancer Research.)

Published
2024
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10. Update on Recommendations for Surveillance for Children with Predisposition to Hematopoietic Malignancy.

Author

Maese LD, Wlodarski MW, Kim SY, Bertuch AA, Bougeard G, Chang VY, Godley LA, Khincha PP, Kuiper RP, Lesmana H, McGee RB, McReynolds LJ, Meade J, Plon SE, Savage SA, Scollon SR, Scott HS, Walsh MF, Nichols KE, and Porter CC

Subjects
Humans, Child, Hematopoietic Stem Cell Transplantation adverse effects, Myelodysplastic Syndromes genetics, Myelodysplastic Syndromes therapy, Myelodysplastic Syndromes diagnosis, Myelodysplastic Syndromes etiology, Practice Guidelines as Topic, Genetic Predisposition to Disease, Hematologic Neoplasms genetics, Hematologic Neoplasms therapy, Hematologic Neoplasms diagnosis
Abstract

Children harboring certain germline gene variants have an increased risk of developing myelodysplastic syndrome (MDS) and other hematopoietic malignancies (HM), such as leukemias and lymphomas. Recent studies have identified an expanding number of these predisposition genes, with variants most prevalent in children with MDS but also found in children with other HM. For some hematopoietic malignancy predispositions (HMP), specifically those with a high risk of MDS, early intervention through hematopoietic stem cell transplantation can favorably impact overall survival, providing a rationale for rigorous surveillance. A multidisciplinary panel of experts at the 2023 AACR Childhood Cancer Predisposition Workshop reviewed the latest advances in the field and updated prior 2017 surveillance recommendations for children with HMP. In addition to general guidance for all children with HMP, which includes annual physical examination, education about the signs and symptoms of HM, consultation with experienced providers, and early assessment by a hematopoietic stem cell transplantation specialist, the panel provided specific recommendations for individuals with a higher risk of MDS based on the affected gene. These recommendations include periodic and comprehensive surveillance for individuals with those syndromes associated with higher risk of MDS, including serial bone marrow examinations to monitor for morphologic changes and deep sequencing for somatic changes in genes associated with HM progression. This approach enables close monitoring of disease evolution based on the individual's genetic profile. As more HMP-related genes are discovered and the disorders' natural histories are better defined, these personalized recommendations will serve as a foundation for future guidelines in managing these conditions., (©2024 American Association for Cancer Research.)

Published
2024
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11. Collaboration to Promote Research and Improve Clinical Care in the Evolving Field of Childhood Cancer Predisposition.

Author

MacFarland SP, Maese L, Rednam SP, Kamihara J, Perrino MR, Nichols KE, Brodeur GM, Schiffman JD, Plon SE, Diller LR, Malkin D, Porter CC, and Villani A

Subjects
Child, Genetic Predisposition to Disease, Genotype, Humans, Mass Screening, Neoplasms diagnosis, Neoplasms genetics, Neoplasms prevention & control
Abstract

Germline pathogenic variants in cancer susceptibility genes are identified in up to 18% of all children with cancer. Because pediatric cancer predisposition syndromes (CPS) themselves are rare and underrecognized, there are limited data to guide the diagnosis and management of affected children and at-risk relatives. Furthermore, the care of affected children requires distinct considerations given the early onset of cancers, lifelong risks of additional cancers, and potential late effects of therapy. Herein, we discuss efforts to leverage existing infrastructure, organize experts, and develop a new consortium to optimize care and advance research for children with CPS. A 2016 workshop organized by the American Association for Cancer Research united many experts in childhood cancer predisposition and resulted in publication of multiple consensus guidelines for tumor surveillance. More recently, several of these authors established the Consortium for Childhood Cancer Predisposition (C3P), a multi-institutional collaboration that provides a structure for systematic research in cancer predisposition, screening, and prevention in children. The Consortium intends to work with other cooperative groups to merge longitudinal data from children with CPS throughout the continuum of the cancer risk period, as well as cancer treatment and survivorship care, to optimize overall outcomes., (©2022 American Association for Cancer Research.)

Published
2022
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