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Your search keyword '"Chromosomes, Bacterial drug effects"' showing total 5 results
Start Over Descriptor "Chromosomes, Bacterial drug effects" Publisher american association for cancer research
5 results on '"Chromosomes, Bacterial drug effects"'

1. Effect of 2-nitrosonaphthalene on bacteria and bacteriophage.

Author

Tagashira Y, Fukuda S, and Yamamoto N

Subjects
Cell Division drug effects, Copper pharmacology, DNA Nucleotidyltransferases metabolism, Genotype, Kinetics, Lysogeny, Manganese pharmacology, Mutation, NAD pharmacology, Recombination, Genetic, Zinc pharmacology, Bacteriophages drug effects, Chromosomes, Bacterial drug effects, Naphthalenes pharmacology, Nitroso Compounds pharmacology, Salmonella typhimurium drug effects
Published
1974

2. Mutagenicity of derivatives of the oncogenic purine N-oxides.

Author

McCuen RW, Stöhrer G, and Sirotnak FM

Subjects
Adenine pharmacology, Bacillus subtilis drug effects, Bromodeoxyuridine pharmacology, Chemical Phenomena, Chemistry, Cyclic N-Oxides pharmacology, DNA, Bacterial, Models, Chemical, Xanthines pharmacology, Carcinogens pharmacology, Chromosomes, Bacterial drug effects, Mutagens, Purines pharmacology
Published
1974

3. In vitro metabolism and microsome-mediated mutagenicity of dialkylnitrosamines in rat, hamster, and mouse tissues.

Author

Bartsch H, Malaveille C, and Montesano R

Subjects
Animals, Carbon Dioxide metabolism, Chromosomes, Bacterial drug effects, Cricetinae, Enzyme Induction, Liver Neoplasms chemically induced, Mice, Microsomes, Liver enzymology, Mixed Function Oxygenases biosynthesis, Neoplasms, Experimental chemically induced, Oxygen Consumption, Phenobarbital pharmacology, Rats, Respiratory Tract Neoplasms chemically induced, Salmonella typhimurium, Species Specificity, Liver metabolism, Lung metabolism, Microsomes enzymology, Mutagens metabolism, Nitrosamines metabolism
Abstract

Rates of conversion of 14C-labeled dimethyl-and diethylnitrosamine by rat and hamster tissue slices to 14CO2 and/or into mutagenic reactants were measured using Salmonella typhimurium G-46 r TA 1530 and fortified tissue fractions in vitro. A correlation between the CO2 production from dimethyl- or diethylnitrosamine in liver or lung and the organ distribution of induced tumors in vivo was observed. As an exception, hamster lung, which is a major target organ in diethylnitrosamine carcinogenesis, did not convert this nitrosamine into metabolites mutagenic for S. typhimurium TA 1530 although the 14CO2 production in vitro was even higher than in hamster liver. The effect of pretreating rats, hamsters, and mice with phenobarbitone on the mutation frequency produced by dimethyl-or diethylnitrosamine in in vitro assays was determined. The relationship between the site of metabolic activation, mutagenicity, and carcinogenicity of the dialkylnitrosamines and the effect of enzyme inducers are discussed.

Published
1975

4. The mutagenicity and DNA-modifying effect of haloalkanes.

Author

Brem H, Stein AB, and Rosenkranz HS

Subjects
DNA Nucleotidyltransferases metabolism, Escherichia coli enzymology, Ethane analogs & derivatives, Genotype, Chromosomes, Bacterial drug effects, DNA, Bacterial biosynthesis, Escherichia coli drug effects, Ethane pharmacology, Mutagens pharmacology, Salmonella typhimurium drug effects
Published
1974

5. The effect of dietary protein deficiency on the ability of isolated hepatic microsomes to alter the mutagenicity of a primary and a secondary carcinogen.

Author

Czygan P, Greim H, Garro A, Schaffner F, and Popper H

Subjects
Animals, Biological Assay, Body Weight, Cytochrome P-450 Enzyme System metabolism, Depression, Chemical, In Vitro Techniques, Male, Mice, Microsomes, Liver enzymology, Nitrosamines metabolism, Nitrosoguanidines metabolism, Organ Size, Salmonella typhimurium drug effects, Biotransformation, Carcinogens pharmacology, Chromosomes, Bacterial drug effects, Dietary Proteins, Microsomes, Liver metabolism, Mutagens metabolism, Nitrosamines pharmacology, Nitrosoguanidines pharmacology
Published
1974

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