1. Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C
- Author
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Aline B, Maddux, Laura, Berbert, Cameron C, Young, Leora R, Feldstein, Laura D, Zambrano, Suden, Kucukak, Margaret M, Newhams, Kristen, Miller, Madyson M, FitzGerald, Jie, He, Natasha B, Halasa, Natalie Z, Cvijanovich, Laura L, Loftis, Tracie C, Walker, Stephanie P, Schwartz, Shira J, Gertz, Keiko M, Tarquinio, Julie C, Fitzgerald, Michele, Kong, Jennifer E, Schuster, Elizabeth H, Mack, Charlotte V, Hobbs, Courtney M, Rowan, Mary A, Staat, Matt S, Zinter, Katherine, Irby, Hillary, Crandall, Heidi, Flori, Melissa L, Cullimore, Ryan A, Nofziger, Steven L, Shein, Mary Glas, Gaspers, Janet R, Hume, Emily R, Levy, Sabrina R, Chen, Manish M, Patel, Mark W, Tenforde, Edie, Weller, Angela P, Campbell, and Adrienne G, Randolph
- Subjects
Adult ,Adolescent ,SARS-CoV-2 ,Aftercare ,COVID-19 ,Patient Discharge ,Systemic Inflammatory Response Syndrome ,United States ,Hospitalization ,Young Adult ,Pediatrics, Perinatology and Child Health ,Humans ,Obesity ,Prospective Studies ,Child - Abstract
OBJECTIVES To evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C). METHODS Multicenter prospective cohort study conducted in 25 United States pediatric hospitals. Patients RESULTS Of 358 eligible patients, 2 to 4 month survey data were available for 119 of 155 (76.8%) with acute COVID-19 and 160 of 203 (78.8%) with MIS-C. Thirteen (11%) patients with acute COVID-19 and 12 (8%) with MIS-C had a readmission. Thirty-two (26.9%) patients with acute COVID-19 had persistent symptoms (22.7%) or activity impairment (14.3%) and 48 (30.0%) with MIS-C had persistent symptoms (20.0%) or activity impairment (21.3%). For patients with acute COVID-19, persistent symptoms (aRR, 1.29 [95% CI, 1.04–1.59]) and activity impairment (aRR, 1.37 [95% CI, 1.06–1.78]) were associated with more organ systems involved. Patients with MIS-C and pre-existing respiratory conditions more frequently had persistent symptoms (aRR, 3.09 [95% CI, 1.55–6.14]) and those with obesity more frequently had activity impairment (aRR, 2.52 [95% CI, 1.35–4.69]). New morbidities were infrequent (9% COVID-19, 1% MIS-C). CONCLUSIONS Over 1 in 4 children hospitalized with acute COVID-19 or MIS-C experienced persistent symptoms or activity impairment for at least 2 months. Patients with MIS-C and respiratory conditions or obesity are at higher risk of prolonged recovery.
- Published
- 2022
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