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A Henderson, A Magier, JT Schwartz. J Pediatr Gastroenterol Nutr. 2020;70(4):482–488 Since a minimally invasive biomarker for disease is desperately needed in eosinophilic esophagitis (EoE), the purpose of this study was to evaluate if peripheral circulating eosinophil progenitors (EoP) could be used as a biomarker for active disease in pediatric EoE patients. Thirty-four total samples from 31 individuals were included in the final analysis. The study participants included pediatric patients, ages 4 to 17 years, including 18 individuals with inactive EoE and 16 with active EoE at the time of endoscopy. Most patients were white boys (70% boys; 97% white), which is consistent with the known disease demographics. In this prospective observational study, peripheral blood …

jj Diaz, B Espin, O Segarra; Gastrointestinal Allergy Working Group of the Spanish Society of Pediatric Gastroenterology, Hepatology and Nutrition (SEGHNP). J Pediatr Gastroenterol Nutr. 2019;68(2):232–236 To describe the clinical presentation and management practices of food protein-induced enterocolitis syndrome (FPIES). The study included 120 patients (0.5 months to 12 years of age) diagnosed with FPIES in 2017 across 37 hospitals in Spain. This study involved a retrospective chart review of patients diagnosed with FPIES using the 2017 international consensus criteria. Age, clinical symptoms, implicated foods, oral food challenge, laboratory values, skin prick testing, number of episodes before diagnosis, and management approach were collected and analyzed …

MD Klinnert, D Atkins, Z Pan. J Pediatr Gastroenterol Nutr. 2019;69(6):682–689 To evaluate if children with eosinophilic esophagitis (EoE) demonstrated an association between health-related quality of life (HRQoL) improvements and symptom reduction during treatment of 1 year, to examine age-related EoE discrete symptom presentation, and to describe residual symptom and HRQoL burden. A prospective cohort of children and their families with established diagnosis of EoE based on previously identified criteria, including presence of upper intestinal symptoms, ≥15 eosinophils/high power field in the esophageal mucosa, treatment with proton pump inhibitors for 2 months before EoE diagnosis, and alternative causes for symptoms and eosinophilia ruled out; and new patients to tertiary care programs at …

B Buyuktiryaki, I Kulhas Celik, SB Erdem. J Pediatr Gastroenterol Nutr. 2020;70(5):574–579 This multi-center study sought to describe the clinical features and natural course of disease in a large group of 257 infants with food protein induced allergic proctocolitis (FPIAP) with assessment of risk factors for persistence of disease. Two hundred and fifty-seven infants diagnosed with FPIAP between 2014 and 2017 in 5 different allergy or gastroenterology outpatient clinics were included in this study. Infants who were admitted with rectal bleeding and had a diagnosis of FPIAP were enrolled. Age, sex, time of onset and type of symptoms, causative food(s), concomitant diseases, physical evaluation results, skin …

JE Markowitz, L Jobe, M Miller, C Frost, Z Laney, R Eke. J Pediatr Gastroenterol Nutr. 2018;66(6):893–897 To report the efficacy and long-term safety of reslizumab (RSZ) for the treatment of pediatric eosinophilic esophagitis (EoE). This was a single-center study including 12 patients (7–16 years old) previously enrolled in a parent multicenter randomized controlled trial receiving either 2 mg/kg RSZ or placebo. All patients had active EoE, esophageal symptoms, and endoscopic findings at enrollment and were permitted to be on a proton pump inhibitor and dietary avoidance. None were on topical steroids. Of the initial …

C Gutierrez-Junquera, S Fernandez-Fernandez, ML Cilleruelo. J Pediatr Gastroenterol Nutr. 2018;67(2):210–216 To evaluate the long-term efficacy and safety of proton pump inhibitors (PPIs) in pediatric eosinophilic esophagitis (EoE). One hundred and nine children between 1 month and 15 years of age with esophageal symptoms and EoE were recruited at 2 pediatric hospitals in Madrid between February 2013 and August 2017. All patients were treated with esomeprazole for 8 weeks, and 72 (66%) achieved histologic remission. Of the 72, 57 children were enrolled in this 1-year study. This was a prospective study of 57 children (73.7% …

EA Erwin, DA Rhoda, M Redmond. J Pediatr Gastroenterol Nutr. 2017;65(5):520–525 This study was designed to develop a model to use food-specific serum immunoglobulin E (IgE) antibodies to predict which patients would have ≥15 eosinophils per high power field (eos/hpf) in the esophagus to help decrease diagnosis and treatment delay for esophageal eosinophilia. There were 2 subsets of patients, 1 exploratory and the other for validation of the predictive model. The exploratory subset included 144 pediatric patients from Nationwide Children’s Hospital seen between April and September 2015, with serum analysis for IgE antibodies to food, and an esophagogastroduodenoscopy with esophageal biopsy. The validation subset included 174 patients with …

L Fahey, G Robinson, K Weinberger, AE Giambrone, AB Solomon. J Pediatr Gastroenterol Nutr. 2017;64(1):22–25 Eosinophilic esophagitis (EoE) is often associated with atopic/allergic disorders. Seasonality has been established in the diagnosis of eosinophilic esophagitis, but there are limited data to support the contribution of aeroallergens to the development of EoE. This pilot study was designed to determine whether there is a seasonal variation in the onset of symptoms and/or diagnosis of EoE and whether these variations correlate with a specific pollen concentration within New York City. All pediatric patients ages 0 to 21 years old diagnosed with EoE by histologic diagnosis between 2002 and 2012 at New York-Presbyterian/Weill Cornell …

JM Fable, M Fernandez, S Goodine, T Lerer, WN Sayej. J Pediatr Gastroenterol Nutr. 2018;66(1):26–32 To compare findings on endoscopy and histology after children with eosinophilic esophagitis (EoE) were treated with swallowed fluticasone propionate (FP) or oral viscous budesonide (OVB). Sixty-eight subjects who were diagnosed with EoE and were between 1 and 20 years old were included in the study. Subjects had therapy with FP or OVB for at least 8 weeks with pre- and posttherapy evaluation by using endoscopy. There were 20 patients who were treated with FP and 48 …