1. Generation Z: Adolescent Xenobiotic Abuse in the 21st Century.
- Author
-
Eggleston W and Stork C
- Subjects
- Adolescent, Amphetamine-Related Disorders diagnosis, Amphetamine-Related Disorders therapy, Cannabinoids adverse effects, Central Nervous System Stimulants adverse effects, Dextroamphetamine adverse effects, Dextromethorphan adverse effects, Excitatory Amino Acid Antagonists adverse effects, Hallucinogens adverse effects, Humans, Inhalant Abuse diagnosis, Inhalant Abuse therapy, Ketamine adverse effects, Methylphenidate adverse effects, N-Methyl-3,4-methylenedioxyamphetamine adverse effects, Phencyclidine Abuse diagnosis, Phencyclidine Abuse therapy, Receptors, N-Methyl-D-Aspartate antagonists & inhibitors, Substance-Related Disorders therapy, Xenobiotics, Designer Drugs adverse effects, Substance-Related Disorders diagnosis
- Abstract
NMDA receptor antagonists include the prescription medication ketamine, the illicit xenobiotics PCP, MXE, and other novel PCP analogs, and the OTC medication DXM. The NMDA receptor antagonist most commonly abused by adolescents in the United States is DXM. These xenobiotics cause dissociative effects by non-competitively inhibiting the action of glutamate at the NMDA receptor. Additionally, these agents modulate the actions of monoamine neurotransmitters, agonize opioid receptors, and inhibit nitric oxide synthase. Patients typically present with sympathomimetic and neuropsychiatric clinical manifestations after abuse of NMDA receptor antagonists. Treatment is generally symptomatic and supportive. Interventions include benzodiazepines, propofol, fluids, antiemetics, aggressive cooling, and respiratory support.
- Published
- 2015