1. Expression of biogenesis of ribosomes BRX1 is associated with malignant progression and prognosis in colorectal cancer
- Author
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Ping Wang, Jianxin Ge, Xiaoli Huang, and Cuihua Lu
- Subjects
Cancer Research ,it also acts as a risk factor for the overall survival of CRC patients ,business.industry ,Colorectal cancer ,medicine.disease ,Ribosome ,BRIX1 expression is positively correlated with CRC tumor stage ,Oncology ,Cancer research ,Medicine ,Original Article ,Radiology, Nuclear Medicine and imaging ,Malignant progression ,business ,Biogenesis - Abstract
Background Upregulated ribosome synthesis is associated with an increased risk of cancer onset. However, the role of biogenesis of ribosomes BRX1 (BRIX1), which is involved in the synthesis of ribosomal 60S subunits, in the progression and prognosis of colorectal cancer (CRC) is not clear. Methods Sixty CRC patients requiring surgical treatment were enrolled in the present prospective study. Patient characteristics were collected at admission. The CRC tissue samples and adjacent normal tissue samples from patients were collected for further quantitative reverse transcription-polymerase chain reaction and Western blot. All enrolled patients were followed up for 12 months, and overall patient survival during follow-up was recorded. Results The level of BRIX1 mRNA in CRC tissues was higher compared with that in adjacent normal tissues (1.0±0.5 vs. 5.5±1.7, P
- Published
- 2020
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