Competing Interests: Conflicts of Interest: Dr. Jara-Palomares reports speaker bureau from Bayer Hispania, Actelion, Rovi, PFIZER, Menarini, and from Leo-Pharma, outside the submitted work; Research funding Leo-Pharma. Dr. Elias-Hernandez reports Honoraria for lectures: MSD; Honoraria for advisory boards activities: Bayer Heathcare, Sanofi; Fees from Bayer Healthcare, GSK, Actelion. Dr. Otero-Candelera: Honoraria for lectures Actelion, Leo-Pharma, Bayer Healthcare, MSD, Sanofi Honoraria for advisory board activities Actelion, Bayer Heathcare, MSD, Sanofi Research funding Bayer Heathcare, Leo-Pharma; Fees: Actelion, Bayer Heathcare, MSD, Leo Pharma. The other authors have no conflicts of interest to declare.