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Antiphospholipid syndrome is an autoimmunological disease, characterized by coexistence of antiphospholipid antibodies in serum and vascular thrombosis or characteristic obstetrical complications. In spite of numerous clinical trials concerning antiphospholipid syndrome in pregnancy, performed in Poland as well as abroad, there are still some unclear aspects connected with this disease. In the paper, authors pay particular attention to patomechanism and contemporary diagnostic trends of antiphospholipid syndrome in pregnancy.

Considering multidirectional mechanism of antiphospholipid antibodies activity, resulting in fetal loss, various therapeutic methods of antiphospholipid syndrome (APS) in pregnant women have been used until now. The paper is a review of literature concerning therapeutic methods of APS in pregnancy currently used or being clinically and experimentally investigated. Their efficacy, in particular, forms of the disease as well as risk of side effects occurrence were presented.

Chlamydia trachomatis is one of the most common sexually transmitted human pathogens. Chlamydial infection is a problem concerning about 12% of young, sexually active persons at reproductive age. Because of subtle or, particularly at women, asymptomatic course, the disease may be imperceptible by patients and untreated until complications occur. When the infection spreads outside cervix and urethra,W irreversible damages in the range of genital-urinary system are often. Fever and leucocytosis can confirm the complications, occurring in the form of pelvic inflammatory disease, causing infertility. Health education, screening programs for high risk patients and proper early treatment of both sexual partners could contribute to decreasing dangerous results of chlamydial infections, especially in aspect of marital infertility problem.

In the paper there has been presented a history of microsurgical technique's introduction to gynaecology, in which it started to be used as a method of treatment of women's mechanical infertility. Different types of microsurgical operations of oviducts have been characterized, with particular regard to their effectiveness. There have been also discussed the factors influencing the final effect of surgical treatment of tubal infertility with the use of microsurgical technique.

Mycoplasmas belong to the large group of microbes and may cause pathologic symptoms in different human organs and systems. The most of them are commensals. They are mostly detected in sexually active persons. Only few of mycoplasmatic species are unquestionable etiological factors of different human infections. They cause illness of respiratory system and kidneys. They are frequently connected with nongonococcal urethritis, epididymitis, prostatitis as well as female pelvic inflammatory disease. Mycoplasmas as etiological factors of genital organ infections have been kept in background of other pathogens for a long time. Recently, the connection between mycoplasmatic infections and marital infertility has been noticed more often. Nowadays this problem is frequently described in Polish as well as foreign scientific literature. The article is an attempt to introduce the problem of mycoplasmatic infections of urogenital male and female system. Simultaneously, it tries to answer the question whether and how they can be an essential cause of marital infertility.

Aim of the Study: The aim of this study was to evaluate the efficacy and safety of 3 years oral specific immunotherapy in patients with perannial allergic rhinitis and bronchial asthma caused by allergy to mites., Material and Methods: Fifteen patients with allergic perannial rhinitis entered the study. Ten of them suffered also from bronchial asthma. During 3 years of therapy we have monitored the appearance of side effects, clinical parameters (symptoms degree and medication usage score) and immunological parameters (serum eosinophil cationic protein concentration and leukotriene C4 liberation by peripheral blood leukocytes upon in vitro specific allergens stimulation)., Results: We have not observed the appearance of any adverse event, so medication has been recognized as a safe. Moreover, we have observed a lot of positive therapeutical effects--the lowering of symptoms scores, accompanied by advantageous changes in immunological parameters. However, in spite of 3 years of therapy, many patients still reported the substantial clinical symptoms, accompanied by still elevated serum ECP concentration and relatively high leukotriene C4 liberation by peripheral blood leukocytes upon in vitro stimulation by specific allergens., Conclusion: Oral specific immunotherapy in the patients with allergic diseases of upper airways is a safe medication but leads only to moderate clinical efficacy accompanied by lowering serum ECP concentration and reducing of leukotrienes C4 liberation by peripheral blood leukocytes stimulated by specific allergens.

A rare case is described of primary benign tumour of small intestine mesentery misdiagnosed as ovarian tumour. The diagnostic difficulties are presented resulting from small number or total absence of symptoms characteristic of this type of disease and from the demonstrated in gynaecological examination connection of the lesion with the genitals. The proper diagnosis is established usually during surgical operation, the extent of which depends on the vascularization of the tumour and on its connection with intestinal wall.