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The developement of novel organocatalytic transformations is described. The elaborate mainly focuses on two catheories of organic reactions, namely azinium cations functionalizations (dearomatizations and aromatic subsititutions) and higher order cycloadditions. Particular attention has been devoted at the study and optimization of the reaction conditions and catalyst structure, in order to maximize yield and enantiopurity of the products as well as minimizing the catalyst loading and using the mildest conditions. The substrate scope of asymmetric reactions has always been thoroughly investigated to demonstrate the broad applicability of the proposed transformations, as well as the performance of synthetic elaborations illustrating the usefulness of the developed methods

The developement of novel organocatalytic transformations is described. The elaborate mainly focuses on two catheories of organic reactions, namely azinium cations functionalizations (dearomatizations and aromatic subsititutions) and higher order cycloadditions. Particular attention has been devoted at the study and optimization of the reaction conditions and catalyst structure, in order to maximize yield and enantiopurity of the products as well as minimizing the catalyst loading and using the mildest conditions. The substrate scope of asymmetric reactions has always been thoroughly investigated to demonstrate the broad applicability of the proposed transformations, as well as the performance of synthetic elaborations illustrating the usefulness of the developed methods

The importance of pyrazole and lactam-based molecules in medical and pharmaceutical fields is underlined by the multitude of active ingredients on trade, such as Sildenafil or Apixaban, by Pfizer. In this work, a synthesis of an organic molecule with promising anticancer activity has been developed. This molecular scaffold is characterized by a δ-lactam-fused pyrazolic core, with a well-known biological activity and amenable of further functionalization. The synthetic strategy adopted for the obtainment of the core was based on a 1,3-dipolar cycloaddition of a nitrilimine with an α,β-unsaturated δ-lactam. Secondly, in order to give the final compound an elevated pharmacological activity, a functionalization with a double “side chain”, namely molecular fragment able to improve the interaction with particular biological receptors, was achieved. The target compound was thus obtained, with a highly convergent synthesis, and will be tested for antiproliferative activities towards different cellular lines.