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Limited to fourth percent or less of the country’s total land area, Egypt’s agricultural landscape is threatened by the repercussions of climate change, desertification, soil depletion, and looming water scarcity. Outside of the Nile river valley and scattered fertile pockets in the desert oases, the vast majority of land is desert: rocky, parched and unable to support conventional farming. According to Egyptian National Action Program 2005 (ENAP), Egypt covers an area of about one million km2 ~ 100 million hectares, out of which about of 76.5 thousands km2 ~ 7.6% of the total area are inhabited, and the remaining (92.4%) area is desert. Desertification is a very complex process governed by several variables which influence each other. It is thus not possible to conclude for the general picture from a single factor alone. This process has a high rate in arid and hyper-arid countries such as Egypt. The main objective of this research was to evaluation the present-day climate-induced desertification in El-Dakhla Oasis, so in this study, the newest method for evaluating and mapping of desertification was used. The mathematic method was carried out by European Commission (EC), (MEditerranean Desertification And Land Use) at the MEDALUS project and booked as ESAs in 1999 integrated with remote sensing and GIS. All indices of the model were revised before using, and regarding to the region condition these indices were defined as key indices which were: Temperature, precipitation, wind, albedo, ground water and soil benchmark, and each benchmark has some sub-layers getting from their geometric mean. Based on the MEDALUS model, each sub-benchmark was quantified according to its quality and given a weighting of between 1.0 and 2.0. All benchmarks should be reinvestigated and adjusted to local conditions. Ultimately, desertification severity was classified in four level including low, moderate, Severe and high Severe. ArcGIS 10 was used to analysis and prepares the layers of quality maps using the geometric mean to integrate the individual sub-indicator maps. In turn the geometric mean of six quality maps was used to generate a single desertification status map. Remote sensing data have great potential to improve models mapping spatial variability of temperature and precipitation since they are available as time worldwide, and have high spatial resolution. The HYDRA visualization software was used to measure the present surface albedo from MODIS product (MOD43C1). Results showed that 60% of the area is classified as Severe, 14 % as moderate and 12%, 16% as low and none affected by desertification respectively. In addition the climatic variations including rainfall, temperature, sunlight, wind indicators were the most important factors affecting desertification process in El-Dakhla Oasis.