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Introduction. Rheumatoid arthritis (RA) is the most common inflammatory joint disease, with progressive destruction of joint structures. Therefore, sensitive and specific markers, useful in monitoring the course of disease are extensively investigated. Aim of the study. The aim of the study was to evaluate the concentration of selected antibodies (anti-CCP, RF lgM and lgG) and hsCRP in patients with rheumatoid arthritis (RA), in different degrees of the disease's progression. Material and methods. Seventy-five patients with rheumatoid arthritis and 26 healthy controls were included in the study. Anti-cyclic citrullinated peptide antibodies (anti-CCP), rheumatoid factor 1gM (RF lgM) and lgG (RF lgG) were determined in the serum by ELISA and C-reactive protein (hsCRP) using latex-enhanced immunonephelometric assays. Results. Concentration of anti-CCP, RF lgM and CRP was significantly higher in patients at an advanced stage, rather than in early and moderate stages of the disease. The percentage of positive results increased with the progression of the disease. We demonstrated a high conformability of positive results (81%) of anti-CCP with RE lgM in patients with severe and end-stage of RA and of negative results (83%) in patients with early and moderate stage. In 14% of RA patients in an advanced stage, in spite of negative RF lgM, anti-CCP antibodies and hs CRP, were also positive. Conclusions. In clinical practice, for an estimation of the degree of RA progression, measurement of anti-CCP antibodies and hsCRP should be considered. [ABSTRACT FROM AUTHOR]