1. Influence of beta adrenergic blockers and their combinations with anticholinergic drugs on epileptiform activity in rabbit hippocampus.
- Author
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Tkatchenko EI, Lossev NA, Kästner I, and Seidel J
- Subjects
- Administration, Topical, Animals, Benactyzine analogs & derivatives, Benactyzine pharmacology, Epilepsies, Partial chemically induced, Hippocampus ultrastructure, Penicillins administration & dosage, Phenoxybenzamine pharmacology, Propranolol pharmacology, Rabbits, Receptors, Muscarinic drug effects, Receptors, Nicotinic drug effects, Adrenergic alpha-Antagonists pharmacology, Adrenergic beta-Antagonists pharmacology, Epilepsies, Partial physiopathology, Hippocampus drug effects
- Abstract
The influence of alpha- and beta-receptor antagonists combined with drugs which act as antagonists at muscarinic and nicotinic receptor sites on epileptic focus produced by topic penicillin application was investigated. The beta-receptor blocking agent caused a faster and more intense activity of epileptogenic focus in comparison with activity in control animals, but the number of seizures decreased relatively for 25%. N-receptor antagonists diminished the facilitating effect of the beta-receptor antagonist on focal activity. Combination of m- and beta-receptor antagonists did not influence the spike activity of the focus. Treatment with alpha-receptor antagonists enhanced spikes and number of seizures only insignificantly. The combination of alpha- and n-receptor blocking substances does not influence the development of the epileptic process. The alpha-receptor antagonist together with the m-receptor blocking drug induces a facilitation of spike activity.
- Published
- 1987