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Females and males differ in several features of their spindle oscillations, as well as in the hemispheric lateralization of their neurocognitive processes. In addition, the hemispheric lateralization of cognitive functions was shown to vary in an age-dependent manner. In spite of the above knowledge, data on the hemispheric lateralization of these oscillatory phenomena are scarce and no sex differences or age effects in the hemispheric lateralization of sleep spindles were reported. Here, we aim to fill this gap by the description of the hemispheric lateralization of sleep spindles in healthy human subjects. Data sets from three research groups were unified (N = 251, age range: 4−69 years, 122 females) in this retrospective multicenter study. The amplitude, density, and duration of slow (frontally dominant) and fast (centroparietally dominant) spindles were analyzed using the individual adjustment method. Hemispheric lateralization was quantified by the (L − R)/mean (L, R) index. Orbitofronto-temporo-occi...