1. Defining malaria burden from morbidity and mortality records, self treatment practices and serological data in Magugu, Babati District, northern Tanzania
- Author
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Arnold Ndaro, Erasto V. Mbugi, William Chambo, Franklin W. Mosha, Jaffu Chilongola, Reginald A. Kavishe, Charles Mwanziva, Maggie P. Kivuyo, Jovin Kitau, Abas Mkwizu, Humphrey Mkali, Alphaxard Manjurano, Clement N. Mweya, William Dolmans, and Alex Sanga
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Tanzania ,Antimalarials ,Seroepidemiologic Studies ,Internal medicine ,parasitic diseases ,Epidemiology ,malaria, morbidity, mortality, diagnosis, treatment, Tanzania ,Prevalence ,medicine ,Humans ,Seroprevalence ,Prospective Studies ,Child ,Disease burden ,Retrospective Studies ,Rapid diagnostic test ,Mosquito Nets ,biology ,business.industry ,Medical record ,Infant ,General Medicine ,Apical membrane ,medicine.disease ,biology.organism_classification ,Malaria ,Self Care ,Child, Preschool ,Immunology ,Female ,business - Abstract
Malaria morbidity and mortality data from clinical records provide essential information towards defining disease burden in the area and for planning control strategies, but should be augmented with data on transmission intensity and serological data as measures for exposure to mala ria. Theobjective of this study was to estimate the malaria burden based on serological data and prevalence of malaria, and compare it with existing self -treatment practices in Magugu in Babati District of northern Tanzania. Prospectively, 470 individuals were selected for the study. Both microscopy and Rapid Diagnostic Test (RDT) were used for malaria diagnosis. Seroprevalence of antibodies to merozoite surface proteins ( MSP - 119) and apical membrane antigen (AMA-1) was performed and the entomologicalinoculation rate (EIR) was estimated. To complement this information, retrospective data on treatment history, prescriptions by physicians and use of bed nets were collected. Malaria prevalence in the area was 6.8% (32/470). Of 130 individuals treated with art emisinin combination therapy (ACT), 22.3 % (29/130) were slide confirmed while 75.3% (98/130) of them were blood smear negative. Three of the slides confirmed individuals were not treated with ACT. Fever was reported in 38.2% of individuals, ofwhom 48.8 % (88/180) were given ACT. Forty-two (32.3%) of those who received ACT had no history of fever. About half (51.1%) of those treated with ACT were children
- Published
- 2011