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Twelve adult albino rabbits with an average weight of 1.42kg were purchased and divided equally into the normal saline, ethanol and ethanol+fructose-treated groups. The ethanol-treated group orally received 1.5g (40%) ethanol/kg body weight as single daily dose, while the ethanol +fructose-treated animals also received the same ethanol dose, but were given in addition, 0.25gfructose/kg body weight after about 10 min of the ethanol administration. The normal saline-treated rabbits were given the equivalent amount of normal saline in lieu of ethanol. The animals were exposed to these various treatments along with their usual feeding pattern for a regular period of 15 weeks. Results showed that the progressive increase (P 0.05) but decreased (P Tanzania Journal of Science Vol. 31 (2) 2005: pp. 5-12 more...

Carbon tetrachloride (CCl4) is haloalkane that possesses a hepatotoxic effect. Material and Methods: The impact of anthocyanin fractions obtained from Hibiscus rosasinensis petal on carbon tetrachloride (CCl4) – induced acute liver damage in wistar rats was studied using a combination of alanine transferase (ALT) activity value and liver: body weight gain ratio as indices. Results: CCl4 treatment significantly increased both ALT value and the liver: body weight gain ratio at the 1% probability level when compared with the control values. Conclusion: Pre-treatment with the anthocyanin fractions reduced the levels of these markers and hence, the degree of liver damage, though with varying potentials. The lead precipitated, non – slimy red fraction possessed the greatest protective property on the rat liver when compared with the other anthocyanin fractions so tested. Keywords : Anthocyanin, carbon tetrachloride, alanine transferase, Hibiscus rosasinensis , liver damage. Sudan Journal of Medical Sciences Vol. 3 (1) 2008: pp. 33-36 more...

No Abstract. Keywords : ‘Ozu\', Ika, Intoxication, Palm juice The East and Central Journal of Pharmaceutical Science Vol. 8 (3) 2007: pp.

Oral fructose administration has been demonstrated to stimulate the oxidation of alcohol. However, its influence on alcohol-induced hyperuricemia is yet to be documented. This study therefore, reports the effect of fructose on alcohol- induced increase in plasma urate in adult albino rabbits. Twelve male adult albino rabbits, divided into A, B and C experimental groups were purchased from Yoha Farms, Warri, Delta State. Group A, the control animals (n=4) were given normal saline, while Group B animals (n=4) orally received 1.5 g (40%) ethanol/kg body weight as single daily dose for a routine period of fifteen weeks. Group C rabbits (n=4) were treated in a similar manner but 0.25 g fructose/kg body weight was usually given after about 10 min of administering the ethanol dose. The results obtained show that ethanol administration significantly increased (P more...

In order to investigate the prevalence of anaemia and related haematological disorders, fifty-seven Nigerian children with Burkitt's Lymphoma, (BL) between the ages of 4-14 years were randomly selected from the paediatric Ward, Ahmadu Bello University Teaching Hospital, Zaria and Kaduna. Twenty-eight age-matched children in apparent good health were included as control subjects. Results show that BL patients had significant (p Journal of Applied Sciences and Environmental Management Vol. 10(3) 2006: 167-170 more...

The effect of some processing techniques (germination boiling and dehulling) on the soluble sugar contents and the emulsion property of processed flour were studied. Results show that germination significantly reduced the raffinose level from the third to the fifth day sprouting period (P 0.05). The contents of other soluble sugars-galactose, glucose and sucrose were increased by germination (P 0.05) but reduced by dehulling (P>0.05). Germination, dehulling and boiling lowered the emulsion stability property of cowpea flour. Even though, it is not conventional to either malt or dehull cowpea seeds before cooking, individuals should be advised to do so, in order to minimize the flatus potential and the accompanied discomfort associated with beans consumption. However, such processing techniques would not be appropriate for foods that need good emulsion. Journal of Applied Sciences and Environmental Management Vol. 9(2) 2005: 65-72 more...

Changes in blood pressure (BP) and plasma urate produced by the bio-transformation of a moderate dose (0.75ml(20%) ethanol/kg body weight) of alcohol were determined after 1h, 6h (oxidation phase) and 12h (post oxidation phase) of consuming the alcohol dose. Twenty healthy Nigerians (ten males and ten females) were randomly selected for the study after their informed consent. Statistical analyses of the results using ANOVA showed a significant decrease (p Key Words: Blood pressure, plasma urate, hypertension, alcohol. Global Jnl Medical Sciences Vol.2(2) 2003: 157-160 more...

In order to estimate the potential prevalence of "Syndrome X" in newly diagnosed cases of insulinoplethoric diabetes mellitus, patients were selected from the emergency (accident) ward, University of Benin Teaching Hospital, Benin City, Nigeria. Both risk factors (plasma lipids) and allied metabolic aberration (plasma glucose and creatinine) were assessed in 100 subjects comprising of 60 patients (30 males, 30 females) within the ages of 35 to 70 years and 40 sex and age matched healthy control subjects. Results showed significant increase in patients mean plasma glucose, tricyglycerol and total cholesterol when compared with the respective mean control values at the 5% probability level, using ANOVA. Their lipoprotein-cholesterol profile also, showed a significant difference (P (Journal of Applied Sciences & Environmental Management: 2002 6(1): 26-28) more...