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Acute heart failure is associated with high hospitalization and mortality rates. A strong, independent risk factor for mortality in patients with heart failure is acute kidney injury, and the condition caused by this connection between disturbances in heart function and proper kidney functioning is cardiorenal syndrome (CRS). This case report discusses the role of continuous renal replacement therapy (CRRT) in the management of a CRS case with septic shock due to pneumonia. A 56-year-old female patient with a history of acute heart failure developed complications of acute kidney dysfunction and was diagnosed with CRS type 1. Standard management was conducted in the intensive cardiac care unit, but the condition of the patient worsened. The patient was admitted to the intensive care unit and underwent CRRT, after which the kidney function and hemodynamic performance of the patient improved. Therefore, the use of CRRT can be a therapeutic option for CRS patients. CRRT acts as an ultrafiltration mechanism that removes circulating cytokines from the blood, reduces volume overload, and addresses electrolyte imbalance, thus enhancing the functioning of the heart and kidneys and potentially improving prognoses., Competing Interests: The authors declare no competing interests., (Copyright: Resiana Karnina et al.)