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Lung cancer is a disease with multifactorial etiology, smoking playing the most important role among its risk factors. Some studies, however, indicate an inverse association between increased body-mass index (BMI) and the risk of lung cancer. In this paper, the association between BMI and lung cancer risk is analysed in two independent studies. In the first study, 751 lung cancer patients were compared to 30 058 controls. In the second study, 91 lung cancer patients were matched to 91 healthy controls. An inversed association was found between increased BMI and lung cancer risk. The inverse association remained significant after adjustment for age, sex, and smoking.

Background: Reg-1alpha plays a role in various types of tissue regeneration., Aim: To evaluate serum Reg-1alpha for the diagnosis of metabolic syndrome., Methods: 14 non-obese, healthy subjects and 15 individuals with metabolic syndrome were studied. Anthropometric and laboratory analysis in sera (Body Mass Index--BMI, insulin, triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, uric acid, aglucose, Quicki calculation, Reg-1alpha) were performed., Results: Reg-1alpha levels did not differ between subjects with metabolic syndrome and healthy subjects (means 597.7 vs. 631.1 ng/l, p < 0.01) and positively correlated only with fasting glucose (r = 0.34; p < 0.01) and age (r = 0.38; p < 0.01); Reg-1alpha correlated even after adjustment to age. Reg-lalpha concentrations did not differ in men and women., Conclusions: Our study, for the first time, indicates that serum Reg-1alpha is not useful for the diagnosis of metabolic syndrome (Tab. 3, Ref. 7).