Descriptor: "Metallothionein pharmacology" / Publisher: administrativnoia zdaniia minzdrava sssr - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Metallothionein pharmacology"' showing total 5 results

Start Over Descriptor "Metallothionein pharmacology" Publisher administrativnoia zdaniia minzdrava sssr

Author: Koterov AN, Trebenok ZA, Pushkareva NB, and Nikol'skiĭ AV
Subjects: Animals, Bone Marrow drug effects, Bone Marrow metabolism, Cell Division drug effects, Mice, Bone Marrow Cells, DNA Replication drug effects, Metallothionein pharmacology, Zinc pharmacology
Published: 1996

Author: Koterov AN, Shagova MV, Shilina NM, and Kon' IIa
Subjects: Animals, Liver drug effects, Liver metabolism, Male, Metallothionein chemistry, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Polymers, Rats, Bromobenzenes toxicity, Lipid Peroxidation drug effects, Metallothionein pharmacology
Published: 1995

Author: Shilina NM and Koterov AN
Subjects: Animals, Lipid Peroxidation, Liver metabolism, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Poisoning blood, Poisoning prevention & control, Alcoholic Intoxication blood, Malondialdehyde blood, Metallothionein pharmacology, Thiobarbiturates blood
Published: 1995

Author: Koterov AN, Trebenok ZA, and Filippovich IV
Subjects: Animals, Male, Metallothionein pharmacology, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Radiation-Protective Agents pharmacology, Zinc, Metallothionein therapeutic use, Radiation Injuries, Experimental prevention & control, Radiation-Protective Agents therapeutic use
Published: 1994

Author: Koterov AN, Sazykin AIu, and Filippovich IV
Subjects: Animals, Lethal Dose 50, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Molecular Weight, Ethanol toxicity, Liver drug effects, Metallothionein pharmacology, Zinc pharmacology
Abstract: The homogeneous drug of zinc-metallothionein (zinc-MT) which characterized according to the molecular weight and UV-absorption spectra was obtained from the liver of the rats preliminary injected with the zinc chloride. It was shown that zinc-MT (0.5-4 mg/kg of protein) injected to the mouse 10 min before the ethanol decrease the acute toxicity of the alcohol. The preliminary injection of the control mixture consisted the albumin, cysteine and zinc chloride in proportions and dose corresponding to the dose 3 mg/kg of zinc-MT did not change LD50 of ethanol. The possible mechanism of the effect is discussed. The most possible is the stabilization of the lipid peroxidation in the liver or the restoration of the thiol groups pool at the alcohol intoxication by the zinc-MT.
Published: 1993

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