Search

Experiments on CBA mice with alcohol withdrawal syndrome showed a reduction of abstinence after injection of serotonin antibodies in dose 5 and 10 mg intraperitoneally. One more result was a decrease of horizontal locomotory activity after injection of 5 mg of serotonin antibodies to mice with 24 hour withdrawal syndrome.

The experiments on C57Bl/6 mice with natural ethanol motivation have shown that passive injection of anti-noradrenaline and particularly antiserotonin antibodies reduces several times alcohol consumption by animals. On the contrary the injection of anti-dopamine antibodies to affect voluntary alcohol consumption by mice have been found.

Effect of splenopentin on some patterns of immunity was studied in mice with chronic alcoholic intoxication. Splenopentin was administrated into animals once intraperitoneally (250 micrograms/kg). Administration of splenopentin was found to normalize several immunological patterns in animals with chronic alcoholic intoxication: the immune response to the thymus-dependent antigen sheep red blood cells and phagocytic activity of peritoneal macrophages. Also observations over C57B1/6 mice characterized by high level of alcoholic motivation showed that alcohol consumption in mice decreased after administration of splenopentin at a dose of 250 micrograms/kg during two weeks.

It was established in rat experiments that adaptation to altitude hypoxia leads to the enhancement of immune response to sheep red blood cells and to an increase in the serum lysozyme level. Adaptation to altitude hypoxia also suppresses adjuvant arthritis and prevents arthritis-induced inhibition of antibody production.

The experiments on CBA mice and guinea-pigs have shown that oral vitamin D administration suppressed natural killer activity, decreased the number of T lymphocytes in the peripheral blood and prolonged allograft survival.

There were phasic changes of immune response in rats and mice with adjuvant disease: an increase of antibody production on the 7th day after the injection of complete Freund's adjuvant and its depression on the 21st day; there was also observed suppression of normal antibody production to O- and Vi-antigens of typhoid bacilli.

Antigenic stimulation (AS) inhibited cathepsin A and D activation in the liver induced by fasting. AS after short-term fasting (4 days) induced the activation increase in the most of lysosomal proteinases by 20-80% in the spleen and thymus, while AS of animals, upon 6- and 8-day fasting depressed the activation of all the investigated lysosomal hydrolases (cathepsin A, B, C, D and arylsulphatases A and B) and decreased the total protein half-life. The revealed peculiarities in the lysosomal proteolytic system function and intensified protein turnover in lymphoid organs may reflect the general reaction of the organism, directed towards the maintenance of immunological homeostasis and, in particular, towards antibody production.

Experiments on C57Bl/6, CBA and DBA/2 mice characterized by different preferences for ethanol have shown that during chronic administration of alcohol to animals with natural ethanol motivation (strain C57Bl/6) the level of antibodies to catecholamines and serotonin was increased on the 3rd month of ethanol intoxication, with the voluntary alcohol consumption in mice decreased by this time. On the contrary in mice rejecting alcohol (strains DBA/2, CBA) no antibodies to catecholamines and serotonin have been found.

Experiments on CBA mice have shown that oral vitamin A administration prevents stress-induced immunological disorders: depression of antibody-forming cell production, decrease in natural killer cell activity and T-lymphocyte mitogenic response. Vitamin A also prevents the development of thymus atrophy, lymphopenia and depression of phagocytic activity of peritoneal macrophages.